2005.9-2008.7 生物化学与分子生物学, 博士学位，大连医科大学 1999.9-2002.7 生化工程专，硕士学位，大连理工大学 1987.9-1991.7 生化工程系，学士学位，华东理工大学

1991.7-1996.6 大连医科大学微生态教研室 助教 1996.6-2002.6 大连医科大学微生态教研室 讲师 2002.6-2013.1 大连医科大学微生态教研室 副教授 2013.1-今 大连医科大学微生态教研室 教授

1.国家自然科学基金：菌群定植对呼吸道免疫耐受功能和特应性进程的作用及机制研究。起止日期2014.1-2017.12； 项目编号： 81370113。本人排名：1课题负责人。 2.国家863项目子课题：临床营养菌种资源库的建立及应用。起止日期2014.1-2016.12； 项目编号：2014AA022209。本人排名：1子课题负责人。 4.国家973项目：肠道微生态代谢、免疫调控的网络互作关系研究。起止日期2013.1-2017.12； 项目编号：2013CB531405。本人排名：第二。

1. Wenkai Yu; Xiaopeng Yuan; Xingche Xu; Rui Ding; Liyuan Pang; Yinhui Liu; Yanjie Guo; Huajun Li; Ming Li; Jieli Yuan; Li Tang; and Shu Wen（通讯作者). Reduced airway microbiota diversity is associated with elevated allergic respiratory inflammation，Ann Allergy Asthma Immunol，2015，115：63-68 2. Ming Li, Weihua Li, Shu Wen（共同第一作者）, Yinhui Liu and Li Tang. Effects of ceftriaxone-induced intestinal dysbacteriosis on dendritic cells of small intestine in mice. Micorobiology and immunology. 2013, 57(8):561-8. IF1.545 3. Fei Gao, Ming Li, Yinhui Li, Chuanzhou Gao, Shu Wen1 and Li Tang.(共同通讯作者) Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity. Gut Patho, 2012.4（1）：19. IF2.738 4. Shu Wen , Hong Li , Mo-Li Wu, Shao-Hua Fan, Qian Wang , Xiao-Hong Shu , Qing-You Kong, Xiao-Yan Chen, Jia Liu. Inhibition of NF-B signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation. J Neurooncol.104(1):169–177,2011. IF 3.214 5. Shu Wen, Hong Li, Jia Liu. Epigenetic Background of Neuronal Fate Determination Progress in Neurobiology. 87(2): 98-117,2009. IF 9.140 6. Shu Wen, Hong Li, Jia Liu. Dynamic Signaling for Neural Stem Cell Fate Determination. Cell Adhesion & Migration. 3(1): 107-117,2009. IF 1.816 7. Zongxin Ling, Shu Wen and Li Tang. Inhibition of VSV by Extracellular RNA from Culture Filtrate of Lactobacillus DM8909 in Vitro. Journal of Hard Tissue Biology. 20(3): 237-246,2011. 8. Chun-Liang Liu, Shu Wen, Yin-Hui Liu, Hua-Jun Li, Jing Xiao, Li Tang. Extracellular Nucleic Acids Secreted by Lactobacillus Regulate TLR9 Expression. Journal of Hard Tissue Biology. 20(2): 153-160, 2011. 9. Lisha Tan, Shu Wen, Ming-ZhongSun, Li Tang. Changes in Protein Profile in Cecum of Mouse with Intestinal Dysbacteriosis Induced by Ceftriaxone Sodium. Journal of Hard Tissue Biology. 20(2): 93-98, 2011. 10. Liu ZL, Li Y, Kong QY, Zhan C, Wang Q, Chen XY, Sun Y, Wen S, Tu CX, Liu J, Li H. Immunohistochemical Profiling of Wnt, NF-κB, Stat3 and Notch Signaling in Human Epidermal Tumors. J Dermatol Sci. 52(2):133-136,2008.