2002年09月-2005年08月 博士 北京大学医学部 1996年09月-1999年07月 硕士 大连医科大学 1987年09月-1993年07月 学士 白求恩医科大学

2013年07月-至今 教授 大连医科大学 2010年10月-2013年06月 研究员 南京大学医学院附属鼓楼医院 1999年07月-2010年10月 副教授 大连大学 1993年08月-1999年08月 住院医师 大连市中心医院

1. 国家自然基金面上项目(81671606)：PEDF表达降低介导IL-34刺激的滑膜MSC异常调控类风湿关节炎Tfh的机制研究(主持人，2017.1-2020.12). 2. 国家自然基金面上项目(81373214)：脐带间充质干细胞通过PGE2 调控类风湿关节炎Tfh 增殖分化及机制的研究(主持人，2014.1-2017.12). 3. 中国博士后科学基金面上一等资助(2012M510073)：TL1A调节Tfh活化在类风湿关节炎B细胞产生抗体中的作用(主持人，2012.1-2013.6). 4. ᠦ୔

1. Wang M, Wei J, Li H, Ouyang X, Sun X, Tang Y, Chen H, Wang B1, Li X*. Leptin Upregulates Peripheral CD4+CXCR5+ICOS+ T Cells via Increased IL-6 in Rheumatoid Arthritis Patients. J Interferon Cytokine Res. 2018 Feb;38(2):86-92. IF 2.377. 2. Sun X, Wei J, Tang Y, Wang B, Zhang Y, Shi L, Guo J, Hu F, Li X*. Leptin-induced migration and angiogenesis in rheumatoid arthritis is mediated by reactive oxygen species. FEBS Open Bio. 2017 Nov 6;7(12):1899-1908. doi: 10.1002/2211-5463.12326. IF 2.143. 3. Tang Y, Wang B, Sun X, Li H, Ouyang X, Wei J, Dai B, Zhang Y*, Li X*. Rheumatoid arthritis fibroblast-like synoviocytes cocultured with PBMC increased peripheral CD4+CXCR5+ICOS+ T cells numbers. Clin Exp Immunol. 2017 Dec;190(3):384-393. doi: 10.1111/cei.13025. IF 3.148. 4. Wang B, Tang Y, Sun X, Ouyang X, Li H, Wei J, Zhang Y*, Li X*. Increased IL-6 expression on THP-1 by IL-34 stimulation up-regulated rheumatoid arthritis Th17 cells. Clin Rheumatol. Clin Rheumatol. 2018 Jan;37(1):127-137. doi: 10.1007/s10067-017-3746-y. IF 2.365. 5. Li M, Wang B, Sun X, Tang Y, Wei X, Ge B, Tang Y, Deng Y, He C, Yuan J, Li X*. Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by DefinedBacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells.Front Immunol. 2017 Jul 12;8:824. IF 6.429. 6. Wang B, Ma Z, Wang M, Sun X, Tang Y, Li M, Zhang Y, Li F, Li X*. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators Inflamm. 2017; 2017:1567120. doi: 10.1155/2017/1567120. Epub 2017 Jun 4. IF 3.232. 7. Ma Z, Wang B, Wang M, Sun X, Tang Y, Li M, Li F, Li X*. TL1A increased IL-6 production on fibroblast-like synoviocytes by preferentially activating TNF receptor 2 in rheumatoid arthritis. Cytokine. 2016 Apr 12; 83:92-98. IF 3.488. 8. Liu R, Li X*, Zhang Z, Zhou M, Sun Y, Su D, Feng X, Gao X, Shi S, Chen W, Sun L*. Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep. 2015 Aug 11;5:12777. doi: 10.1038/srep12777. IF 5.228. 9. Liu R, Su D, Zhou M, Feng X, Li X(co-corresponding author), Sun L*. Umbilical cord mesenchymal stem cells inhibit the differentiation of circulating T follicular helper cells in patients with primary Sjogren's syndrome through the secretion of indoleamine 2,3-dioxygenase. Rheumatology (Oxford). 2015 Feb;54(2):332-42. IF 4.524. 他引：2 10. Shi D, Li X(co-first author), Chen H, Che N, Zhou S, Lu Z, Shi S, Sun L*. High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus. Pathol Biol (Paris). 2014 Dec;62(6):382-90. IF 1.200. 他引：1 11. Che N, Li X(co-first author), Zhang L, Liu R, Chen H, Gao X, Shi S, Chen W, Sun L*. Impaired B Cell Inhibition by Lupus Bone Marrow Mesenchymal Stem Cells Is Caused by Reduced CCL2 Expression. J Immunol. 2014 Nov 15;193(10):5306-14. IF 4.922. 他引：3 12. Zhou M, Liu R, Su D, Feng X, Li X*. TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis. Cytokine. 2014 Sep;69(1):125-30. IF 2.664. 他引：4 13. Li X, Wang D, Liang J, Zhang H, Sun L*. Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. Bone Marrow Transplant, 2013April, 48(4):544-50. IF 3.466. 他引：15 14. Li X，Wang D, Lu Z, Chen J, Zhang H, Sun L*. Answer to 'Toxic epidermal necrolysis with failure of re-epithelialization. Could umbilical cord mesenchymal stem cell transplantation have a role?' J Eur Acad Dermatol Venereol, 2013July, 27(7):925. doi: 10.1111/j.1468-3083.2012.04666.x. IF3.105. 他引：0 15. Li X，Wang D, Lu Z, Chen J, Zhang H, Sun L*. Umbilical cord mesenchymal stem cell transplantation in drug-induced Stevens-Johnson syndrome. J Eur Acad Dermatol Venereol, 2013 May , 27(5):659-61. IF 3.105. 他引：3