2006.9–2009.7，大连医科大学，生物化学与分子生物学专业，博士 2003.9–2006.7，大连医科大学，生物化学与分子生物学专业，硕士1998.9–2003.7，齐齐哈尔医学院，临床医学专业，医学学士

2017.12-至今,大连医科大学,生物化学与分子生物学教研室,教授，硕士生导师 博士生导师 2012.12-2017.12,大连医科大学,生物化学与分子生物学教研室,副教授，硕士生导师 2009.9-2012.12,大连医科大学,生物化学与分子生物学教研室,讲师

1.国家自然科学基金，ST6Gal-I介导细胞表面N-聚糖唾液酸化在肝癌发生发展和免疫逃逸中的作用及机制研究，2015.01-2018.12， 项目主持人，80万 2.国家自然科学基金，Caveolin-1调控小鼠肝癌细胞表面ａ2,6-唾液酸化与肿瘤粘附，2011.01-2013.12，项目主持人，20万 3.辽宁省自然科学基金，唾液酸转移酶在前列腺癌细胞侵袭转移中的作用及分子机制研究，2017.5-2019.4，项目主持人，5万 4.辽宁省自然科学基金，ST6Gal-I高表达在肝癌发生发展中的作用及分子ᠦ୔

1.Wu Y, Chen X, Wang S, Wang S. Advances in the relationship between glycosyltransferases and multidrug resistance in cancer. Clin Chim Acta. 2019 Aug;495:417-421.（corresponding author） 2.Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, Wang S. Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway. Cell Death Dis. 2019 May 10;10(5):374.（co-corresponding author） 3.Wang L, Li S, Yu X, Han Y, Wu Y, Wang S, Chen X, Zhang J, Wang S. α2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling. J Physiol Biochem. 2019 Jun;75(2):199-207. （co-corresponding author） 4.Yuan Q, Chen X, Han Y, Lei T, Wu Q, Yu X, Wang L, Fan Z, Wang S. Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. Int J Cancer. 2018 Nov 1;143(9):2319-2330. （corresponding author） 5.Yu S, Lv H, Zhang H, Jiang Y, Hong Y, Xia R, Zhang Q, Ju W, Jiang L, Ou G, Zhang J, Wang S, Zhang J. Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway. Biochem Biophys Res Commun. 2017,485(2):432-439. （co-corresponding author） 6.Yuan S, Wang L, Chen X, Fan B, Yuan Q, Zhang H, Yang D, Wang S: Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016, 84:1776-1782. （co-corresponding author） 7.Yu X, Zhao Y, Wang L, Chen X, Su Z, Zhang H, Yuan Q, Wang S, Sialylated beta1, 6 branched N-glycans modulate the adhesion, invasion and metastasis of hepatocarcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016, 84:1654-1661.（corresponding author） 8.Yu X, Wu Q, Wang L, Zhao Y, Zhang Q, Meng Q, Pawan, Wang S. Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway. Tumour Biol. 2016 Sep;37(9):12213-12221.（corresponding author） 9.Wei A, Fan B, Zhao Y, Zhang H, Wang L, Yu X, Yuan Q, Yang D, Wang S. ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway. Oncotarget. 2016 Aug 30. doi:10.18632/oncotarget.11699.（co-corresponding author） 10.Chen X, Wang L, Zhao Y, Yuan S, Wu Q, Zhu X, Niang B, Wang S, Zhang J. ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway. Oncotarget. 2016 Jun 21. doi:10.18632/oncotarget.10192. （co-corresponding author） 11.Wang, S., Chen, X., Wei, A., Yu, X., Niang, B. & Zhang, J*. (2015) alpha2,6-linked sialic acids on N-glycans modulate the adhesion of hepatocarcinoma cells to lymph nodes, Tumour biology. 36, 885-92. 12.Meng, Q., Ren, C., Wang, L., Zhao, Y. & Wang, S*. (2015) Knockdown of ST6Gal-I inhibits the growth and invasion of osteosarcoma MG-63 cells, Biomedicine & pharmacotherapy. 72, 172-8. （corresponding author）

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