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顾杰

领域:生物产业 学校:江苏大学职称:副教授

重金属的分子毒理与解毒机制 钙离子稳态失衡相关疾病 环境污染与临床疾病相关研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2001/09-2005/06,扬州大学,生物科学与技术,学士学位 2005/09-2008/06,扬州大学,生物化学与分子生物学,硕士学位 2009/03-2011/02,香港浸会大学,生物学,硕士学位 2011/07-2014/06,香港浸会大学,生物学,博士学位

工作经历

2014/07-2015/06,香港浸会大学,生物系,助理研究员 2015/06-2016/08,江苏大学,生命科学研究院,助理研究员 2016/09-至今,江苏大学,生命科学研究院,副研究员

项目课题经历

科研项目 国家自然科学基金青年基金,31600952,钙离子敏感受体CaSR的激活可减轻镉对肾小管上皮细胞的毒性的分子机理的研究,2017/01-2019/12,20万,在研,主持 香港General Research Fund项目,GRF 261610、 “The Identification of Stanniocalcin-1 Target Cells and the Characterization of the In-Situ Ca2+-Sensing and Transport Mechanisms in Gill Epithelial Cells of Japanese Eels”, 2010-2013,HK$986,000,已结题,参与

论文、成果、著作等

【近年发表的论文】 (1). Wang Y, Ji X, Dai S, Liu H, Yan D, Zhou Y, Gu J*, Shi H*. Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP. J Inorg Biochem. 2018,189:199-207. (2). Gu J#, Dai S#, Liu Y, Liu H, Zhang Y, Ji X, Yu F, Zhou Y, Chen L, Tse WKF, Wong CKC, Chen B, Shi H*. Activation of Ca2+-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells. Sci Rep. 2018, 8(1):1092. (3). Gu J#, Dai S#, Liu H, Cao Q, Yin S, Lai KP, Tse WKF*, Wong CKC, Shi H*. Identification of immune-related genes in gill cells of Japanese eels (Anguilla japonica) in adaptation to water salinity changes. Fish & Shellfish Imunol. 2018, 73:288-296. (4). Gu J#, Li JW#, Tse KF, Chan TF, Wong CK*. Transcriptomic responses of CS gland of Japanese eels (Anguilla japonica) to Changes in Water Salinity. Sci Rep. 2015, 5: 9836. (5). Gu J, Law AY, Yeung BH, Wong CK*. Characterization of stanniocalcin 1 binding and signaling in gill cells of Japanese eels. J Mol Endocrinol. 2015, 54(3):305-314. (6). Gu J, Law AY, Yeung BH, Wong CK*. Activation of gill Ca2+-sensing receptor as a protective pathway to reduce Ca2+-induced cytotoxicity. 2014, J Mol Endocrinol. 53(2):155-64. (7). Gu J, Chan LS, Wong CK, Wong NS, Wong CK, Leung KN, Mak NK*. Effect of benzo[a]pyrene on the production of vascular endothelial growth factor by human eosinophilic leukemia EoL-1 cells. J Environ Pathol Toxicol Oncol. 2011, 30(3):241-249. (8). Lai KP, Li JW, Gu J, Chan TF, Tse WK, Wong CK*. Transcriptomic analysis reveals specific osmoregulatory adaptive responses in gill mitochondria-rich cells and pavement cells of the Japanese eel. BMC Genomics. 2015, 16:1072. (9). Tse WK, Sun J, Zhang H, Lai KP, Gu J, Sheung Law AY, Yee Yeung BH, Ching Chow S, Qiu JW, Wong CK*. Data for transcriptomic and iTRAQ proteomic analysis of Anguilla japonica gills in response to osmotic stress. Data Brief. 2015, 3:120-125. (10). Tse WK, Sun J, Zhang H, Lai KP, Gu J, Qiu JW, Wong CK*. iTRAQ-based quantitative proteomic analysis reveals acute hypo-osmotic responsive proteins in the gills of the Japanese eel (Anguilla japonica). J Proteomics. 2014, 105:133-143. (11). Cao Q, Gu J, Wang D, Liang F, Zhang H, Li X, Yin S*. Physiological mechanism of osmoregulatory adaptation in anguillid eels. Fish Physiol Biochem. 2018, 44(2):423-433

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