2007-2013 江苏大学医学院 肿瘤生物学博士 2001-2003 苏州大学医学院 细胞生物学硕士 1990-1994 南京师范大学 生物学学士

现任医学院副院长，基础医学研究所副所长。 2010-2012 年在 MD 安德森癌症中心工作两年 2015 至今 江苏大学医学院 教授 2007-2014 江苏大学医学院 副教授 2000-2007 江苏大学医学院 讲师 1994-2000 镇江医学院 助教 2010-2012 德克萨斯大学 MD 安德森癌症中心 访问副教授

基 金 1. 企事业单位委托科技项目。高产纳豆激酶菌种筛选与液体发酵生产工艺 的开发及其产品开发。起止时间：2018-09-03 至 2019-12-31。金额：50 万 元。合同编号：20170091。负责人。 2. 国家自然科学基金面上项目。 LDHA-ME2-ACSS2 代谢轴促进 GBM 细 胞间质转化的作用及其临床意义。起止时间：2018-01 至 2021-12。金额： 69.6 万元。项目批准号：81772694。主持人。 3. 企事业单位委托科技项目。益生菌在口腔制剂和妇科洗液相关产品开发。起止时间：2016-08-01 至 2017-12-31。金额：50 万元。合同编号：20160241。 负责人。 4. 国家自然科学基金面上项目。 FoxM1 精氨酸甲基化和稳定性的调控机制 及其在 GBM 间质转化中的作用。起止时间：2014-01 至 2017-12。金额： 70 万元。 项目批准号：81372718。主持人。 5. 国家自然科学基金面上项目。 组蛋白 H3K4 甲基化在核移植胚胎核重编 程中的作用和机制研究。起止时间：2011-01 至 2015-12。 金额：58 万 元。 项目批准号：81170573。参与者。 6. 国家自然基金青年项目。 Egr-1 调控低氧下细胞自噬引起肝癌化疗抵抗 的机制研究。起止时间：2011-01 至 2014-12。 金额：25 万元。 项目批 准号：31100964。参与者。 7 市科技局科技支撑计划。 腺病毒介导的 ING4 基因通过 RhoA/ROCK 通 路抑制人脑胶质瘤细胞迁移的实验研究。 起止时间：2009-06 至 2012-06。 金额：2.5 万元。项目批准号：SH2009018。主持人。 8. 省部级项目。 Slit2/Robol 在嗅鞘细胞移植促进损伤脊髓轴束生长中的作 用。起止时间：2008-09 至 2009-09。金额： 3 万元。项目批准号：30571878。 主持人。 9. 省教育厅高校自然科学研究面上项目。 clathrin /caveolae 介导的内吞作用 对 TrkA 核转位通路影响的研究。 起止时间：2007-07 至 2009-12。金额： 3 万元。 项目批准号：07KJB310018。主持人。 10.国家自然基金青年项目。嗅鞘细胞组织工程支架移植联合应用聚乙二醇 修复脊髓损伤的实验研究。 起止时间：2006-01 至 2008-12。金额：22 万 元。 项目批准号：30570981。参与者。

在国际期刊上发表研究论文 80 多篇，包括 Cancer cell 、 Cancer research 、 JBC 、 Stem cell 等著名期刊 发表论文： 2019 83. Ming Yu, Yuanyuan Niu, Dan Zhou, Rong Jiang, Lirong Zhang, Huixiang Ju, Aihua Gong, Shenqiang Zou, Miaomiao Zhang, Fengyi Du: Hyaluronic Acid-Functionalized Gadolinium Doped Iron Oxide Nanoparticles for Atherosclerosis-Targeted Mr Imaging. Journal of Biomedical Nanotechnology.2019 Jan 1;15(1):127-137. DOI: 10.1166/jbn.2019.2660. 82. Wenwen Deng,Fengxia Shao,Qinghua He,Qiang Wang,Wentao Shi,Qingtong Yu,Xia Cao, Chunlai Feng,Shiqi Bi,Jiaxin Chen,Ping Ma,Yang Li,Aihua Gong,Shanshan Tong, Jiangnan Yu,Myron Spector,Ximing Xu,Zhijian Zhang:EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells.Advanced materials. 2019 Jan 11:e1806861. doi: 10.1002/adma.201806861. 2018 80. Yong Yang, Jie Ren, Yuhao Sun, Yuan Xue, Zhijian Zhang, Aihua Gong, Baofeng Wang, Zhihong Zhong, Zhenwen Cui, Zhiyu Xi, Guo-yuan Yang, Qingfang Sun ,Liuguan Bian: A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation. Cell Death & Differentiation. 2018 Oct ; 25(10):1870-1884. DOI: 10.1038/s41418-018-0137-0. 79. Zhiwen Song,Xiu Han,Hongjun Zou,Bin Zhang,Ya Ding,Xu Xu,Jian Zeng,Jinbo Liu, Aihua Gong*: PTEN–GSK3β–MOB1 axis controls neurite outgrowth in vitro and in vivo. Cellular and Molecular Life Sciences. 2018 Dec;75(23):4445-4464.DOI: 10.1007/ s00018-018-2890-0. 78. Wang K, Liang W, Zhu B, Zhu L, Xiong Y, Gong A* :Expression profile of Notch signaling pathway-related microRNAs in immune cells of collagen-induced arthritis mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 Oct;34(10):865-869. 77. Lingliang Long,Ning Wang,Yuanyuan Han,Meiyu Huang,Xiangqi Yuan,Siyu Cao, Aihua Gong ,Kun Wang: A coumarin-based fluorescent probe for monitoring labile ferrous iron in living systems. Analyst. 2018 May 29;143(11):2555-2562.DOI: 10.1039/ c8an00556g. 76. Chunli Zhang,Xiu Han, Xiao Xu, Zhengrong Zhou, Xi Chen,Yu Tang, Jie Cheng,Nida Fatima Moazzam,Fei Liu,Jing Xu,Wanxin Peng,Fengyi Du, Bin Zhang, Zhiwen Song, Jian Zeng,Aihua Gong*: FoxM1 drives ADAM17/EGFR activation loop to promote mesenchymal transition in glioblastoma. Cell Death & Disease. 2018 May; 9(5): 469;,DOI: 10.1038/s41419-018-0482-4 75. Meiting Zhang, Yi Zhao,Youli Zhang, Dawei Wang,Shuming Gu, Wen Feng,Wanxin Peng,Aihua Gong*,MinXu: LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease .2018 May;1864(5 Pt A):1770-1782. DOI: 10.1016/ j.bbadis. 2018.03.005. 74. Shenqiang Zou, Xiaofang Zhu,Lirong Zhang, Fan Guo,Miaomiao Zhang,Youwen Tan,Aihua Gong,Zhengzou Fang, Huixiang Ju,Chaoyang Wu, Fengyi Du: Biomineralization-Inspired Synthesis of Cerium-Doped Carbonaceous Nanoparticles for Highly Hydroxyl Radical Scavenging Activity. Nanoscale Research Letters. (2018) 13:76;, DOI:10.1186/s11671-017-2427-8 73 Xinyuan Hu, Nitin Tandra,Zhijian Zhang, Aihua Gong, Jingyan Chen, Yang Li, Qian Chen, Wenrong Xu, Hui Qian: Identification and differentiation therapy strategy of pterygium in vitro. American Journal of Translational Research. 2018; 10(8): 2619–2627 72. Xuelian Chen,Lirong Zhang, Yujie Jiang, Lian Song,Yanfang Liu, Fang Cheng, Xin Fan,Xiongfeng Cao,Aihua Gong,Dongqing Wang,Haitao Zhu: Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis.Journal of Experimental ＆ Clinical Cancer Research. (2018) 37:77; DOI: 10.1186/s13046-018-0726-2 71. Meng Zhou,Youli Zhang,Hong Wei,Junbo He,Dawei Wang,Baoding Chen,Jian Zeng,Aihua Gong, and Min Xu: Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.Oncology Letters. 2018 Mar; 15(3): 3192–3196.DOI: 10.3892/ol.2017.7672 70. Hongjun Zou,Ya Ding,Weifeng Shi,Xu Xu,Aihua Gong, Zhijian Zhang,Jinbo Liu: Erratum to: MicroRNA-29c/PTEN Pathway is Involved in Mice Brain Development and Modulates Neurite Outgrowth in PC12 Cells. Cellular and Molecular Neurobiology. 2018 Mar;38(2):575.DOI: 10.1007/s10571-017-0493-1 71. Meng Zhou,Youli Zhang,Hong Wei,Junbo He,Dawei Wang,Baoding Chen,Jian Zeng,Aihua Gong, and Min Xu: Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.Oncology Letters. 2018 Mar; 15(3): 3192–3196.DOI: 10.3892/ol.2017.7672 70. Hongjun Zou,Ya Ding,Weifeng Shi,Xu Xu,Aihua Gong, Zhijian Zhang,Jinbo Liu: Erratum to: MicroRNA-29c/PTEN Pathway is Involved in Mice Brain Development and Modulates Neurite Outgrowth in PC12 Cells. Cellular and Molecular Neurobiology. 2018 Mar;38(2):575.DOI: 10.1007/s10571-017-0493-1 69. Lingliang Long,Meiyu Huang,Ning Wang, Yanjun Wu,Kun Wang,Aihua Gong,Zhijian Zhang, Jonathan L. Sessler: A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons. Journal of the American Chemical Society. 2018 February 07; 140(5): 1870–1875;, DOI: 10.1021/jacs.7b12545 68. Zhiwen Song, Xiu Han, Liming Shen, Hongjun Zou, Bin Zhang,Jinbo Liu, Aihua Gong*: PTEN silencing enhances neuronal proliferation and differentiation by activating PI3K/Akt/GSK3β pathway in vitro. Experimental Cell Research. 2018 Feb 15;363(2):179-187.DOI: 10.1016/j.yexcr.2018.01.001. 67. Meiyu Huang ,Prof. Dr.,Lingliang Long ,Ning Wang ,Xiangqi Yuan, Siyu Cao ,Aihua Gong ,Prof. Dr. Kun Wang: Bifunctional Fluorescent Probe for Sequential Sensing of Thiols and Primary Aliphatic Amines in Distinct Fluorescence Channels. Chemistry,an Asian Journal. 2018 Mar 2;13(5):560-567.DOI: 10.1002/asia.201701733. 66. Youli Zhang,Dawei Wang,Meiting Zhang,Hong Wei,Ying Lu, Yaocheng Sun, Meng Zhou,Shuming Gu, Wen Feng,Huizhi Wang,Jian Zeng,Aihua Gong*.MinXu: Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition / proliferation dichotomy in gastric cancer cells. Experimental Cell Research. 2018 Jan 1;362(1):43-50.DOI: 10.1016/j.yexcr.2017.10.035. 2017 65. Gang Xu, Lihua Zhu, Yan Wang, Yawei Shi, Aihua Gong, Chaoyang Wu: Stattic Enhances Radiosensitivity and Reduces Radio-Induced Migration and Invasion in HCC Cell Lines through an Apoptosis Pathway.Biomed Research International. 2017;2017:1832494.DOI: 10.1155/2017/1832494. 64. Gaorui Bian, Gregory B. Gloor, Aihua Gong, Changsheng Jia,Wei Zhang, Jun Hu, Hong Zhang, Yumei Zhang, Zhenqing Zhou, Jiangao Zhang, Jeremy P. Burton, Gregor Reid, Yongliang Xiao, Qiang Zeng, Kaiping Yang, Jiangang Lia: The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere. 2017 Sep 27;2(5). pii: e00327-17.DOI: 10.1128/mSphere.00327-17. 63. Fengyi Du, Jiaming Lou, Rong Jiang, Zhengzou Fang, Xuefen Zhao,Yuanyuan Niu, Shenqiang Zou, Miaomiao Zhang, Aihua Gong, Chaoyang Wu: Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor.International Journal of Nanomedicine. 2017 Aug 21;12:5973-5992. DOI: 10.2147/IJN.S130455. 62. Jixiang Chen, Yaocheng Sun, Xiao Xu, Dawei Wang, Junbo He, Hailang Zhou, Ying Lu, Jian Zeng, Fengyi Du, Aihua Gong*, Min Xu: YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. Cell Cycle. 2017;16(23):2259-2271.DOI: 10.1080/15384101.2017.1380125. 61. Bin Zhang, Aihua Gong,Hui Shi, Qingli Bie,Zhaofeng Liang, Peipei Wu, Fei Mao, Hui Qian, Wenrong Xu: Identification of a novel YAP-14-3-3ζ negative feedback loop in gastric cancer. Oncotarget. 2017;8(42):71894-71910. DOI: 10.18632/oncotarget.18011. 60. Hui Shi, Xiao Xu, Bin Zhang, Jiahao Xu, Zhaoji Pan, Aihua Gong, Xu Zhang, Rong Li, Yaoxiang Sun, Yongmin Yan, Fei Mao, Hui Qian, Wenrong Xu: 3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing. Theranostics. 2017 Apr 10;7(6):1674-1688.DOI: 10.7150/thno.18082.59. Youli Zhang, Meng Zhou, Hong Wei, Hailang Zhou, Junbo He, Ying Lu, Dawei Wang, Baoding Chen, Jian Zeng, Wanxin Peng, Fengyi Du, Aihua Gong*, Min Xu: Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway. International Journal of Oncology .2017; DOI:10.3892/ijo.2017.3896 58. Jue Wang, Youli Zhang, Hong Wei, Xingxing Zhang, Yan Wu, Aihua Gong, Yu Xia, Wenbing Wang, Min Xu: The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis. Oncotarget .2017; DOI: 10.18632/oncotarget.15330 57. Wan-xin Peng, Xiu Han, Chun-li Zhang, Lu Ge, Feng-yi Du, Jie Jin, Ai-hua Gong*: FoxM1-mediated RFC5 expression promotes temozolomide resistance. Cell Biology and Toxicology . 2017; DOI:10.1007/s10565-017-9381-1 56. W-x Peng, Y-y Wan, A-h Gong, L Ge, J Jin, M Xu, C-y Wu: Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells. Oncogenesis .2017; 6(1):e292., DOI:10.1038/oncsis.2016.91 2016 55. Yongmin Yan, Wenqian Jiang, Youwen Tan, Shengqiang Zou, Hongguang Zhang, Fei Mao, Aihua Gong, Hui Qian, Wenrong Xu: hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury. Molecular Therapy. 2017 Feb 1;25(2):465-479.DOI:10.1016/j.ymthe.2016.11.019 54. Min Xu, Junbo He, Jie Li, Wen Feng, Hailang Zhou, Hong Wei, Meng Zhou, Ying Lu, Jian Zeng, Wanxin Peng, Fengyi Du, Aihua Gong*: Methyl-CpG-binding domain 3 inhibits epithelial–mesenchymal transition in pancreatic cancer cells via TGF-β/Smad signalling. British Journal of Cancer. 2016; DOI:10.1038/bjc.2016.397 54. Min Xu, Junbo He, Jie Li, Wen Feng, Hailang Zhou, Hong Wei, Meng Zhou, Ying Lu, Jian Zeng, Wanxin Peng, Fengyi Du, Aihua Gong*: Methyl-CpG-binding domain 3 inhibits epithelial–mesenchymal transition in pancreatic cancer cells via TGF-β/Smad signalling. British Journal of Cancer. 2016; DOI:10.1038/bjc.2016.397 53. Qijun Li, Ming Zhou, Qingfeng Yang, Qian Wu, Jing Shi, Aihua Gong, Mingyang Yang: Efficient Room-Temperature Phosphorescence from Nitrogen-Doped Carbon Dots in Composite Matrices. Chemistry of Materials. 11/2016; 28(22):8221-8227., DOI: 10.1021/acs.chemmater.6b03049 52. Min Xu, Jing Cai, Hong Wei, Meng Zhou, Ping Xu, Hongmei Huang, Wanxin Peng, Fengyi Du, Aihua Gong*, Youli Zhang: Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats. Cellular Physiology and Biochemistry. 11/2016; 40(1-2):277-286., DOI:10.1159/000452544 51. Kang Sun, Song-Bing He, Jian-Guo Qu, Sheng-Chun Dang, Ji-Xiang Chen, Ai-Hua Gong, Rong Xie, Jian-Xin Zhang: IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro. World Journal of Gastroenterology .11/2016; 22(42):9368., DOI:10.3748/wjg.v22.i42.9368 50. Zhijian Zhang, Zhengnan Li, Wenwen Deng, Qinghua He, Qiang Wang, Wentao Shi, Qian Chen, Wenjing Yang, Myron Spector, Aihua Gong, Jiangnan Yu, Ximing Xu: Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochemical and Biophysical Research Communications. 10/2016; 480(4)., DOI:10.1016/j.bbrc.2016.10.115 49

申请专利 13 项。 1. 发明人：唐宇，龚爱华。发明名称：薁黄酸钠和西吡氯铵复方啫喱的制 备及其应用。申请号：CN 108030782 A 2. 发明人：唐宇，龚爱华。发明名称：乳酸链球菌素、西吡氯铵和氟化钠 复方啫喱的制备及应用。申请号：CN 107753931 A 3. 发明人：唐宇，龚爱华。发明名称：薁黄酸钠和西吡氯铵复方漱口水的 制备及其应用。申请号：CN 107951733 A 4. 发明人：龚爱华，朱沛煌。发明名称：一种高产纳豆激酶的枯草芽孢杆 菌亚种及其应用。申请号：CN 107828686 A 5. 发明人：龚爱华，朱沛煌。发明名称：一种高产纳豆激酶的枯草芽孢杆 菌及其应用。申请号：CN 107841473 A 6. 发明人：龚爱华，朱沛煌。发明名称：一种高产纳豆激酶的枯草芽孢杆 菌诱变菌株及其应用。申请号：CN 107828685 A 7. 发明人：龚爱华，唐宇，陈洁，曾建，韩秀，陈曦，刘菲。发明名称： 乳酸链球菌素、西吡氯铵和氟化钠漱口水的制备及其应用。申请号：CN 107753930 A 8. 发明人：龚爱华，朱沛煌，严永敏，曾建，彭琬昕，杜凤移，崔恒林。 发明名称：一种高产纳豆激酶的液态培养基。申请号：CN 107475234 A 9. 发明人：龚爱华，朱沛煌，严永敏，曾建，彭琬昕，杜凤移，崔恒林。 发明名称：含有黑芝麻、桑葚、蓝莓成分的高产纳豆激酶液态培养基。 申请号：CN 107475232 A 10. 发明人：龚爱华，朱沛煌，严永敏，曾建，彭琬昕，杜凤移，崔恒林。 发明名称：含有红枣、枸杞、山楂成分的高产纳豆激酶液态培养基。申 请号：CN 107475231 A 11. 发明人：龚爱华，朱沛煌，严永敏，曾建，彭琬昕，杜凤移，崔恒林。 发明名称：含有芝麻、百合、山药成分的高产纳豆激酶液态培养基。申 请号：CN 107475230 A 12. 发明人：胡新远，张志坚，钱晖，龚爱华，陈京燕，贾浩源。发明名称： 人眼球结膜胬肉干细胞细胞株。申请号：CN 106011065 A 13. 发明人：杜凤移，张丽，张礼荣，张苗苗，华晔，龚爱华，邵启祥。发 明名称：一种荧光-MRI 双模态影像探针的制备方法及其应用。申请号： 201410393974.0