主持的科研项目： 1. 江苏省自然科学基金青年基金，BK20160505，CalR调控副溶血弧菌VI型分泌系统的分子机制研究，2016/07-2019/06，19万元，在研，主持； 2. 国家自然科学基金青年基金，81601809，副溶血弧菌ToxR对III分泌系统和耐热性直接溶血素的表达调控研究，2017/01-2019/12，18万元，在研，主持； 3. 国家自然科学基金面上项目（合作申报），31671290，副溶血弧菌毒力基因表达的密度感应调控机制，2017/01-2020/12，21万元，在研，共同主持； 4. 病原微生物生物安全国家重点实验室开放课题，SKLPBS1438，密度感应系统调控副溶血弧菌III型分泌系统的分子机制研究，2015/01-2016/12，20万元，已结题，主持； 5. 江苏大学科研启动基金资助项目，1291280020，H-NS调控副溶血弧菌生物膜形成的分子机制研究，2015/01-2016/12，5万元，已结题，主持。

公开发表学术论文60余篇，其中第一作者或通讯作者SCI论文30余篇，代表性杂志包括Journal of Bacteriology、Environmental Microbiology, BMC Microbiology、Future Microbiology、Frontiers in Microbiology、Frontiers in Cellular and Infection Microbiology等。参编中文专著3部，英文专著1部。 近5年代表性论著： 1. Renfei Lu*, Hao Tang*, Yue Qiu, Wenhui Yang, Huiying Yang, Dongsheng Zhou, Xinxiang Huang, Lingfei Hu#, Yiquan Zhang#. Quorum sensing regulates the transcription of lateral flagellar genes in Vibrio parahaemolyticus. Future Microbiology, 2019, accepted. 2. Yiquan Zhang, Lingfei Hu, Yue Qiu, George Osei-Adjei, Hao Tang, Ying Zhang, Rui Zhang, Xiumei Sheng, Shungao Sheng, Wenhui Yang, Huiying Yang, Zhe Yin, Ruifu Yang, Xinxiang Huang, Dongsheng Zhou#. QsvR integrates into quorum sensing circuit to control Vibrio parahaemolyticus virulence. Environmental Microbiology, 2019, 21(3):1054-1067. (doi: 10.1111/1462-2920.14524) 3. Yiquan Zhang, Lingfei Hu, George Osei-Adjei, Ying Zhang, Wenhui Yang, Zhe Yin, Renyun Lu, Xiumei Sheng, Ruifu Yang, Xinxiang Huang#, Dongsheng Zhou#. Autoregulation of ToxR and its regulatory actions on major virulence gene loci in Vibrio parahaemolyticus. Frontiers in Cellular and Infection Microbiology, 2018, 8: 291. (doi: 10.3389/fcimb.2018.00291) 4. Yiquan Zhang. 2018. Genetic Regulation Analysis of Yersinia pestis. Springer book: Yersinia pestis Protocols, Chapter 22, pages 183-202. 5. He Gao*, Jialiang Xu*, Xin Lu, Jie Li, Jing Lou, Hongqun Zhao, Baowei Diao, Qiannan Shi, Yiquan Zhang#, Biao Kan#. Expression of hemolysin is regulated under the collective actions of HapR, Fur, and HlyU in Vibrio cholerae El Tor serogroup O1. Frontiers in Microbiology, 2018, 9: 1310. (doi: 10.3389/fmicb.2018.01310) 6. Lei Liu, Haihong Fang, Yinjuan Ding, Yaqiong Zheng, Liping Cai, Shangen Zheng#, Yiquan Zhang#. Transcriptional regulation between the two global regulators RovA and CRP in Yersinia pestis biovar Microtus. Current Microbiology, 2018, 8: 374. (doi: 10.3389/fcimb.2018.00347) 7. Long Chen, Yue Qiu, Hao Tang, Lingfei Hu, Wenhui Yang, Xiaojue Zhu, Xinxiang Huang, Tang Wang#, Yiquan Zhang#. ToxR is required for biofilm formation and motility of Vibrio parahaemolyticus. Biomedical and Environmental Sciences, 2018, 31 (11): 848-850. (doi: 10.3967/bes2018.112) 8. Renfei Lu, George Osei-Adjei, Xinxiang Huang, Yiquan Zhang#. Role and regulation of the orphan AphA protein of quorum sensing in pathogenic Vibrios. Future Microbiology, 2018, 13: 383-391. (doi: 10.2217/fmb-2017-0165) 9. Linlin Zhang, Yiwei Weng, Yu Wu, Xueying Wang, Zhe Yin, Huiying Yang, Wenhui Yang#, Yiquan Zhang#. H-NS is an activator of exopolysaccharide biosynthesis genes transcription in Vibrio parahaemolyticus. Microbial Pathogenesis, 2018,116: 164-167. (doi: 10.1016/j.micpath.2018.01.025) 10. Ying Zhang, Lin Xia, Liping Lin, Hao Tang, George Osei-Adjei, Shungao Xu, Yiquan Zhang#, Xinxiang Huang#. Reciprocal regulation of OmpR and Hfq and their regulatory actions on the Vi polysaccharide capsular antigen in Salmonella enterica Serovar Typhi. Current Microbiology, 2018, 75 (6): 773-778. (doi: 10.1007/s00284-018-1447-7) 11. George Osei-Adjei, Xinxiang Huang, Yiquan Zhang#. The extracellular proteases produced by Vibrio parahaemolyticus. World Journal of Microbiology & Biotechnology, 2018, 24 (5): 68. (doi: 10.1007/s11274-018-2453-4) 12. Qin Cai, Yiquan Zhang#. Structure, function and regulation of the thermostable direct hemolysin (TDH) in pandemic Vibrio parahaemolyticus. Microbial Pathogenesis, 2018,123: 242-245. (doi: 10.1016/j.micpath.2018.07.021) 13. Yiquan Zhang, He Gao, George Osei-Adjei, Ying Zhang, Wenhui Yang, Huiying Yang, Zhe Yin, Xinxiang Huang#, Dongsheng Zhou#. Transcriptional Regulation of the Type VI Secretion System 1 Genes by Quorum Sensing and ToxR in Vibrio parahaemolyticus. Frontiers in Microbiology, 2017, 8. (doi: 10.3389/fmicb.2017.02005) 14. George Osei-Adjei*, He Gao*, Ying Zhang, Lingyu Zhang, Wenhui Yang, Huiying Yang, Zhe Yin, Xinxiang Huang#, Yiquan Zhang#, Dongsheng Zhou#. Regulatory actions of ToxR and CalR on their own genes and type III secretion system 1 in Vibrio parahaemolyticus. Oncotarget, 2017, 8(39): 65809-65822. (doi: 10.18632/oncotarget.19498) 15. He Gao, Lingyu Zhang, George Osei-Adjei, Wenhui Yang, Dongsheng Zhou, Xinxiang Huang, Huiying Yang, Zhe Yin#, Yiquan Zhang#. Transcriptional regulation of cpsQ-mfpABC and mfpABC by CalR in Vibrio parahaemolyticus. MicrobiologyOpen, 2017, 6(4): e470. (doi: 10.1002/mbo3.470) 16. Lingyu Zhang, George Osei-Adjei, Ying Zhang, He Gao, Wenhui Yang, Dongsheng Zhou, Xinxiang Huang#, Huiying Yang#, Yiquan Zhang#. CalR is required for the expression of T6SS2 and the adhesion of Vibrio parahaemolyticus to HeLa cells. Archives of Microbiology, 2017, 199(6):931-938. (doi: 10.1007/s00203-017-1361-6) 17. Yiquan Zhang, Ying Zhang, He Gao, Lingyu Zhang, Zhe Yin, Xinxiang Huang, Dongsheng Zhou, Huiying Yang, Wenhui Yang#, Li Wang#. Vibrio parahaemolyticus CalR down regulates the thermostable direct hemolysin (TDH) gene transcription and thereby inhibits hemolytic activity. Gene, 2017, 613: 39-44. ( doi: 10.1016/j.gene.2017.03.001) 18. Yiquan Zhang, George Osei-Adjei, Bin Ni, Haihong Fang, Lingyu Zhang, Xin Zhao, Xinxiang Huang, Huiying Yang, Wenhui Yang#, Fengjun Sun#. Transcription of exsD is repressed directly by H-NS in Vibrio parahaemolyticus. Microbial Pathogenesis, 2016, 97: 221-5. (doi: 10.1016/j.micpath) 19. Yiquan Zhang, Lingyu Zhang, Shuning Hou, Xinxiang Huang, Fengjun Sun, He Gao#. The master quorum-sensing regulator OpaR is activated indirectly by H-NS in Vibrio parahaemolyticus. Current Microbiology, 2016, 73 (1): 71-6. (doi:10.1007/s00284-016-1018-8) 20. Yiquan Zhang, Fengjun Sun, Huiying Yang, Lei Liu, Bin Ni, Xinxiang Huang, Ruifu Yang, Dongsheng Zhou#. Current Microbiology, 2015, 70 (3): 398-403. (doi: 10.1007/s00284-014-0736-z) * 表示第一作者；# 表示通讯作者。