教育背景
2007/9 - 2012/6,江苏大学,临床检验诊断学专业,研究生,医学博士
2002/9 - 2007/7,江苏大学,医学检验专业,本科,医学学士
工作经历
2015/7 -至今,江苏大学,临床检验与输血学教研室,副教授,硕士生导师
2014/1 - 2015/6,江苏大学,临床检验与输血学教研室,讲师,硕士生导师
2012/6 - 2013/12,江苏大学,临床检验与输血学教研室,讲师
项目课题经历
主持科研项目
1. 国家自然基金面上项目,81772641,区域淋巴结转移胃癌exosome重塑骨髓MSC作用及其分子机制,2018/01-2021/12, 58万
2. 中国博士后科学基金面上项目,2017M611740,骨髓MSC促淋巴结转移胃癌恶化作用及其分子机制,2017/05-2018/11, 5 万
3. 江苏省博士后基金,1701027A,淋巴结转移胃癌exosome重塑骨髓MSC促胃癌作用及机制,2017/10-2019/05, 6万
4. 国家自然基金青年基金,81302119,胃癌MSC 源性miRNAs 再编程骨髓MSC 作用及机制研究,2014/01-2016/12, 23万
5. 江苏省自然科学基金,BK20130540,microRNA再编程骨髓间质干细胞转分化及机制研究,2013/06-2016/07,20万
6. 江苏省普通高校自然科学研究项目,13KJB320001,microRNA 调控骨髓MSC向胃癌MSC转分化及机制研究,2013/08-2015/12,3.2万
7. 江苏大学“青年骨干教师培养工程”青年学术带头人 2014/01-2017/12 6万
参与科研项目
1. 国家自然基金面上项目,81472334,胃癌MSC源性细胞因子调节Th17/ Treg细胞分化作用机制及其临床应用,2015/01-2018/12,70 万 排名3
2. 国家自然基金面上项目,81071421,GC-MSC和癌组织来源的MicroRNAs
在胃癌诊治中的作用,2011/01-2013/12,36万 排名2
3. 江苏省科技厅临床医学科技专项,BL2012055,癌相关间质干细胞源性miRNA分析技术在胃癌分子诊断中的应用,2012/01-2015/12,100万 排名2
论文、成果、著作等
发表学术论文情况
发表SCI论文35篇,其中第一作者、共同第一作者和通讯作者SCI论文12篇,代表性论文列表如下:
1. Wang M, Yang F, Qiu R, Zhu M, Zhang H, Xu W, Shen B, Zhu W. The role of mmu-miR-155-5p-NF-κB signaling in the education of bone marrow-derived mesenchymal stem cells by gastric cancer cells, Cancer Med, 2018 Feb 14. doi: 10.1002/cam4.1355 第一作者/通讯作者 (SCI IF:3.362 )
2. Wang M, Chen B, Sun XX, Zhao XD, Zhao YY, Sun L, Xu CG, Shen B, Su ZL, Xu WR, Zhu W. Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression, Exp Cell Res, 2017, 361(1):19-29第一作者(SCI IF:3.546)
3. Huang F, Wang D, Yao Y, Wang M. PDGF signaling in cancer progression, Int J Clin Exp Med, 2017, 10 (7) :9918-9929 通讯作者 (SCI IF:1.069)
4. Zhu M, Wang M, Yang F, Tian Y, Cai J, Yang H, Fu H, Mao F, Zhu W, Qian H, Xu W. miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κB p65 activation, Oncotarget, 2016, 7(13):16567-16580 共同第一作者/通讯作者(SCI IF:5.165)
5. Cai J, Wang M, Zhu M, Zhang Q, Zhang X, Yan Y, Qian H, Xu W. N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration, Mol Med Rep, 2016, 13(2):1083-1090共同第一作者(SCI IF:1.692)
6. Wang M, Cai J, Huang F, Zhu M, Zhang Q, Yang T, Zhang X, Qian H1, Xu W. Pre-treatment of human umbilical cord-derived mesenchymal stem cells with interleukin-6 abolishes their growth-promoting effect on gastric cancer cells, Int J Mol Med, 2015,35(2):367-375第一作者(SCI IF:2.341)
7. Zhang B, Wang M, Gong A, Zhang X, Wu X, Zhu Y, Shi H, Wu L, Zhu W, Qian H, Xu W. HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing, Stem Cells, 2015, 33(7):2158-2168 共同第一作者 (SCI IF:5.599)
8. Wang M, Zhao C, Shi H, Zhang B, Zhang L, Zhang X, Wang S, Wu X, Yang T, Huang F, Cai J, Zhu Q, Zhu W, Qian H, Xu W. Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer, Br J Cancer, 2014, 110(5):1199-1210 第一作者 (SCI检索 IF: 6.176)高被引用论文
9. Huang F, Wang M, Yang T, Cai J, Zhang Q, Sun Z, Wu X, Zhang X, Zhu W, Qian H, Xu W. Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression, J Cancer Res Clin Oncol, 2014,140(11):1835-1848 共同第一作者 (SCI IF: 3.503)
10. Zhang Q, Wang M, Huang F, Yang T, Cai J, Zhang X, Zhu W, Qian H, Xu W. H. pylori infection-induced MSC differentiation into CAFs promotes epithelial-mesenchymal transition in gastric epithelial cells, Int J Mol Med, 2013, 32(6): 1465-1473 共同第一作者 (SCI IF:2.341)
11. Wang M, Gu H, Qian H, Zhu W, Zhao C, Zhang X, Tao Y, Zhang L, Xu W. miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation, Eur J Cancer, 2013, 49(8):2010-2021 第一作者 (SCI IF: 6.029)
12. Wang M, Gu H, Wang S, Qian H, Zhu W, Zhang L, Zhao C, Tao Y, Xu W. Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer, Mol Med Rep, 2012, 5(6):1514-1520 第一作者 (SCI IF:1.692)
13. Xu R, Zhao X, Zhao Y, Chen B, Sun L, Xu C, Shen B, Wang M, Xu W, Zhu W. Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4+ T cells, Cell Prolif, 2017 Oct 22. doi: 10.1111/cpr.12399. (SCI IF:4.111)
14. Qian H, Ding X, Zhang J, Mao F, Sun Z, Jia H, Yin L, Wang M, Zhang X, Zhang B, Yan Y, Zhu W, Xu W. Cancer stemness and metastatic potential of the novel tumor cell line K3: an inner mutated cell of bone marrow-derived mesenchymal stem cells. Oncotarget, 2017, 8(24):39522-39533 (SCI IF: 5.165)
15. Zhu Y, Yu J, Yin L, Zhou Y, Sun Z, Jia H, Tao Y, Liu W, Zhang B, Zhang J, Wang M, Zhang X, Yan Y, Xue J, Gu H, Mao F, Xu W, Qian H. MicroRNA-146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury, Stem Cells Transl Med, 2016, 5(10):1406-1415 (SCI IF: 4.247)
16. Zhang B, Shi Y, Gong A, Pan Z, Shi H, Yang H, Fu H, Yan Y, Zhang X, Wang M, Zhu W, Qian H, Xu W. HucMSC Exosome-Delivered 14-3-3ζ Orchestrates Self-Control of the Wnt Response via Modulation of YAP During Cutaneous Regeneration, Stem Cells, 2016, 34(10):2485-2500 (SCI IF:5.599)
17. Mao F, Wang M, Wang J, Xu WR. The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer, Inflamm Res, 2015,64(9):661-669 (SCI IF: 2.659)
18. Xu XJ, Gao S, Wang M, Qian H, Gu GY, Zhang K, Xu WR.Methylation status of the FHIT gene in the transformed human mesenchymal F6 stem cell line, Oncol Lett, 2015, 9(6):2661-2666 (SCI IF: 1.39)
19. Ji R, Zhang B, Zhang X, Xue J, Yuan X, Yan Y, Wang M, Zhu W, Qian H, Xu W. Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer, Cell Cycle, 2015, 14(15):2473-2483 (SCI IF: 3.53)
20. Zhu Q, Zhang X, Zhang L, Li W, Wu H, Yuan X, Mao F, Wang M, Zhu W, Qian H, Xu W. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression, Cell Death Dis, 2014, 5:e1295 (SCI IF: 5.965)
21. Yang T, Zhang X, Wang M, Zhang J, Huang F, Cai J, Zhang Q, Mao F, Zhu W, Qian H, Xu W. Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-κB pathway, PLoS One, 2014, 9(5):e97569 (SCI IF: 2.806)
22. Zhang L, Xu Z, Xu X, Zhang B, Wu H, Wang M, Zhang X, Yang T, Cai J, Yan Y, Mao F, Zhu W, Shao Q, Qian H, Xu W.SALL4, a novel marker for human gastric carcinogenesis and metastasis, Oncogene, 2014,33(48):5491-5500 (SCI IF: 7.519)
23. Li W, Zhang Q, Wang M, Wu H, Mao F, Zhang B, Ji R, Gao S, Sun Z, Zhu W, Qian H, Chen Y, Xu W. Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury, Stem Cell Res, 2013, 10(3):405-416 (SCI IF: 3.892)
24. Li T, Yan Y, Wang B, Qian H, Zhang X, Shen L, Wang M, Zhou Y, Zhu W, Li W, Xu W. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis, Stem Cells Dev, 2013, 22(6):845-854 (SCI IF: 3.562)
25. Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X, Wang M, Qian H, Xu W. Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo, Cancer Lett, 2012, 315(1):28-37 (SCI IF:6.375)
26. Xu X, Qian H, Zhu W, Zhang X, Yan Y, Wang M, Xu W. Isolation of cancer stem cells from transformed human mesenchymal stem cell line F6, J Mol Med (Berl), 2010, 88(11):1181-1190 (SCI IF: 4.686)
27. Xu X, Zhang X, Wang S, Qian H, Zhu W, Cao H, Wang M, Chen Y, Xu W. Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues, J Cancer Res Clin Oncol, 2011, 137(3):495-504 (SCI IF:3.503)
专利、著作版权等
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