教育背景
2007/9 - 2010/7,江苏大学,临床检验诊断学,博士
2003/9 - 2006/7,江苏大学,临床检验诊断学,硕士
1998/9 - 2003/7,江苏大学,临床检验诊断学,学士
工作经历
2013/7 -至今,江苏大学,医学院,副教授,硕士生导师
2012/4-2014/4,美国M. D. Anderson癌症研究中心,访问学者
2008/7 - 2013/6,江苏大学,基础医学与医学技术学院,讲师
2003/7 - 2008/6,江苏大学,医学技术学院,助教
项目课题经历
主持或参加科研项目及人才计划项目情况:
1.国家自然科学基金青年基金项目、81200312、间质干细胞来源exosome抗肝纤维化作用机制研究、2013/01-2015/12、23万元、在研、主持。
2.江苏省自然科学基金青年基金项目、BK2012288、脐带间质干细胞来源microvesicle在肝纤维化修复中作用及机制、2012/07-2015/6、20万元、在研、主持。
3.国家自然科学基金面上项目、K-RAS 驱动的Lin28B/let-7通路维持PCSCs 自我更新及其机制、81472333、2015/01-2018/12、70万元、在研、参加。
4.国家自然科学基金主任基金项目、microRNAs在间质干细胞介导的急性肾损伤修复中的作用及机制研究、31140063、2012/1-2012/12、10万元、结题、参加。
5.江苏省博士研究生创新基金、慢病毒介导TNFα-Tumstatin融合基因修饰脐带MSCs靶向治疗胃癌实验研究、CX09B_215Z、2010/1-2012/12、结题、主持。
论文、成果、著作等
发表主要论文:
1.Yan Y, Zuo X, Wei D. Concise review: emerging role of CD44 in cancer stem cells: a promising biomarker and therapeutic target. Stem cells translational medicine, 2015. [Epub ahead of print] (IF: 5.709)
2.Yan Y(#), Zhu Y(#), Sun F(#), Zhang B, Li L, Sun Z, Li W, Qian H, Zhu W, Xu W(*), Extracellular regulated protein kinases 1/2 phosphorylation is required for hepatic differentiation of human umbilical cord-derived mesenchymal stem cells, Exp Biol Med, 2015, 240(4):534-45. (5-year IF: 3.020)
3.Li T(#), Yan Y(#), Wang B, Qian H(*), Zhang X, Shen L, Wang M, Zhou Y, Zhu W, Li W, Xu W(*), Exosomes derived from human umbilical cord mesenchymal stem cellsalleviate liver fibrosis, Stem Cells Dev, 2013, 22(6): 845-54. (IF: 4.202)
4.Yan Y, Qian H, Zhu W, Mao F, Li T, Xu W(*), Hepatocyte growth factor modified humanumbilical cord mesenchymal stem cells accelerate the recovery of mouse hepatic injury, Romanian Biotechnological Letters,2012,17(5):7673-75.(IF: 0.363)
5.Yan Y, Xu W(*), Qian H, Zhu W, Mao F, Zhang X, Tumstatin 45-132-TNFα suppresses tumor growth via anti-angiogenic effects and cytotoxicity, Biotech and Applied Bioch, 2010, 56(3):119-27.(IF: 1.512)
6.Yan Y, Xu W(*), Qian H, Si Y, Zhu W, Cao H , Zhou H, Mao F. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo, Liver international, 2009, 29:356–365. (IF:2.987)
7.Yan Y, Hao S, Qian H, Fei R, Xu W,Expression and detection of human phosphodiesterase 3B gene in baculovirus,ACTA PHARMACOL SIN, 2006, 27(sup1): 247-247. (IF: 1.397, SCI收录增刊摘要论文)
8.Chen Y, Qian H, Zhu W, Zhang X, Yan Y, Ye S, Peng X, Li W, Xu W(*), Hepatocyte growth factor modification promotes the amelioration effects of human umbilical cord mesenchymal stem cells on rat acute kidney injury, Stem Cells Dev, 2011, 20(1): 103-113. (IF: 4. 202)
9.Qian Q, Qian H, Zhang X, Zhu W, Yan Y, Ye S, Peng X, Li W, Xu Z, Sun L, Xu W(*), 5-Azacytidine Induces Cardiac Differentiation of Human Umbilical Cord- Derived Mesenchymal Stem Cells by Activating Extracellular Regulated Kinase, Stem Cells Dev, 2011, 21(1): 67-75. (IF: 4. 202)
10.Xu X, Qian H, Zhu W, Yan Y, Xu W(*), Isolation of cancer stem cells from transformed human mesenchymal stem cell line F6, J Mol Med, 2010, 88(11): 1181-1190.(IF: 4. 739)
11.Cao H, Qian H, Xu W(*), Zhu W, Zhang X, Chen Y, Wang M, Yan Y, Xie Y, Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats, Biotechnol Lett, 2010, 32: 725-732. (IF: 1.736)
12.Sun X, Cai H, Qian H, Zhu W, Yan Y, Xu H, Xu W(*), Mesenchymal stem cells isolated from human uterine cervix cancer tissues, Cell Biol Int, 2011, 35(2): 119-123. (IF: 1.635)
13.Mao F, Xu W(*), Qian H, Zhu W, Yan Y, Shao Q, Xu H, Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis, Inflamm Res, 2010, 59(3): 219-225.(IF:2.143)
专利、著作版权等
1.专利:许文荣,钱晖,朱伟,严永敏,毛飞,黄玲,沈俐,脐带间质干细胞来源膜性囊泡及其应用,2012年,中国,授权号:201010226049.0。
2.专利:张斌,许文荣,钱晖,朱伟,严永敏,王梅,朱艳华,史惠,吴莉珺,潘昭吉,人脐带间质干细胞分泌的exosome治疗皮肤损伤的应用,2014年,中国,申请号:201410775694.6。
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