• 1983.8 – 1986.8 中国科学院，热带植物研究所，助研 • 1989.8 – 1990.8 武汉大学，生物工程中心，助教 • 1994.8 – 1995.8 美国圣-久德儿童研究医院 (St. Jude’s Children Research Hospital) ，免疫系，博士后 • 1995.9 – 2002.8 美国康乃尔大学 (Cornell University) ，分子医学系，研究员 • 2002.9 - 2011.12 美国怀斯研究中心 (Weis Center for ReseႵ୔

其间研究工作的主要成就是：（1） 发现了肿瘤发生和恶化的新的重要机理。其研究发现泛素连接酶和酪氨酸激酶一起调节表皮生长因子受体的信号传递，并通过这一调节来提高肺癌细胞的迁移。这一发现对理解肺癌细胞转移的分子机理有非常重要的意义。 （2）发现了一个非受体酪氨酸激酶的激活机理。这个非受体酪氨酸激酶的表达与多种肿瘤的恶化密切相关。这一机理是癌细胞信号传递的一条新的途径。（3）构建了一种新的癌症基因治疗蛋白分子。这一蛋白分子能识别癌细胞中的生长信号，并将癌细胞的生长信号转换成死亡信号，特异性地灭杀癌细胞。

这些学术成果部分发表在国际一流学术刊物上，达到国际领先水平。在国际一流学术杂志上发表了二十多篇学术论文，总影响因子为107.34 （2010年），平均影响因子5.11，总引用次数达 800 多次，平均每篇论文引用次数近40次。 主要论著 已发表的部分代表性学术论文： 1. Lin, Q., Wang, J, Childress, C, Sudol, M, Carey, DJ, Yang, W. (2010) HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates EGF-induced degradation of EGFR and ACK. Mol Cell Biol. 30(6):1541-1554. 2. Wang, J, Peng, Q, Lin, Q., Childress, C, Carey, DJ, Yang, W. (2010) Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition. J Biol Chem. 285(16):12279-12288. 3. Lin, Q., Zhu, F., Yang, W. (2009) Coupling cellular mitogenesis to apoptosis by designed bio-molecules. Cell Signal. 22:190-196. 4. Shen, F., Lin, Q., Gu, Y., Childress, C., Yang, W. (2007) Activated Cdc42-associated Kinase 1 (ACK1) Is a Component of EGF Receptor Signaling Complex and Regulates EGF Receptor Degradation. Mol Biol Cell. 18: 732-742. 5. Lin, Q., Yang, W., Baird, D., Feng, Q., Cerione, R.A. (2006) Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J Biol Chem. 281(46):35253-62. 6. Lin, Q., Yang, W., Cerione, R.A. (2006) Measurement of epidermal growth factor receptor turnover and effects of Cdc42. Methods in Enzymol. 406:614-25. 7. Qiong Lin, Reina N. Fuji, Wannian Yang, Richard A. Cerione (2003) RhoGDI Is Required for Cdc42-Mediated Cellular Transformation. Curr Biol. 13:1469-79. 8. Qiong Lin, Charles G. Lo, Richard A. Cerione, and Wannian Yang (2002) The Cdc42- target ACK2 interacts with SH3PX1 (sorting nexin 9) to regulate EGF receptor degradation. J Biol Chem. 277:10134-8. 9. Wannian Yang, Qiong Lin, Jihe Zhao, Jun-Lin Guan, Richard A. Cerione (2001) The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes. J Biol Chem. 276:43987-93. 10. Qiong Lin, Sarah E. Ruuska, Natacha S. Shaw, Diane Dong, and Noa Noy, 1999, Ligand selectivity of the peroxisome proliferator-activated receptor a. Biochemistry 38:185-190 11. Wannian Yang, Qiong Lin, Jun-Lin Guan, and Richard A. Cerione, 1999, activation of the Cdc42-associated tyrosine kinase 2 by cell adhesion via integrin b1. J. Biol. Chem. 274:8524-8530 12. Qiong Lin, Stephen J. Taylor, and David Shalloway, 1997, Specificity and determinants of Sam68 RNA binding: implications for the biological function of KH domains. J. Biol. Chem. 272 : 27274-27280. 13. Qiong Lin, Jurg Rohrer, R. Culter Allen, Mark Larche, Jeffrey M. Greene, Ann O. Shigeoka, Richard A. Gatti, D. Christian Derauf, John W. Belmont, and Mary Ellen Conley, 1996, A single strand conformation polymorphism study of CD40 ligand: efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome. J. Clin. Invest. 97: 196-201