博士研究生导师，江苏大学国际基因组学研究中心常务副主任

部分主持的科研项目 (1) 国家自然科学基金面上项目、reHMGB1诱导NKp46(+)ILC3扩增分泌IL-22调控EAM小鼠心肌纤维化的研究、81871244，2019~-2022、56万，在研，主持 (2)国家自然科学基金面上项目、ANGII/AT1R调节心肌浸润Ly6C(hi)单核细胞极化参与小鼠EAM发生的机制研究、81671567、2017~2020、60万、在研、主持 (3)国家自然科学基金面上项目、81370084、HMGB1调节Mφ极化参与Th17介导的小鼠EAM发生机制研究、2014~2017、70万、已完成、主持。 (4)国家自然科学基金青年项目、81001319、HMGB1诱导EAM小鼠Th17细胞增多的机制研究、2011~2013、22万、已完成、主持。 (5) 江苏省333工程科研项目资助计划、BRA2018016、reHMGB1诱导NKp46+ILC3扩增分泌IL-22调控心肌纤维化的研究、2018-2020、20万、主持、在研

发表的部分学术论文 （1）Lu H, Wu Y, Shao X, Zhou S, Jiang Y, Chen R, Zong G, Xu H, Su Z. ANG II facilitated CD11+Ly6Chi cells reprogramming into M1-like macrophage through Erk1/2 or p38-Stat3 pathway and involved in EAM. J Leukoc Biol. 2018; 103(4):719-730（通讯作者） （2）Su Z, Sun C, Zhou C, Liu Y, Zhu H, Sandoghchian S, Zheng D, Peng T, Zhang Y, Jiao Z, Wang S, Xu H. HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. Eur J Immunol. 2011;41(12): 3586-95. （3）Su Z, Ni P, She P, Liu Y, Richard SA, Xu W, Zhu H, Wang J. Bio-HMGB1 from breast cancer contributes to M-MDSC differentiation from bone marrow progenitor cells and facilitates conversion of monocytes into MDSC-like cells. Cancer Immunol Immunother. 2017;66(3):391-401 （4）Su Z, Yin J, Wang T, Sun Y, Ni P, Ma R, Zhu H, Zheng D, Shen H, Xu W, Xu H. Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCbeta/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1. J Cell Mol Med. 2014;18(9):1740-51. （5）Su Z, Lu H, Jiang H, Zhu H, Li Z, Zhang P, Ni P, Shen H, Xu W, Xu H. IFN-γ-producing Th17 cells bias by HMGB1-T-bet/RUNX3 axis might contribute to progression of coronary artery atherosclerosis. Atherosclerosis. 2015;243(2):421-8. （6）Liu Y, Zhu H, Su Z, Sun C, Yin J, Yuan H, Sandoghchian S, Jiao Z, Wang S, Xu H. IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKC/Erk1/2/NF-B-dependent signaling pathway. Int Immunol. 2012,24(10):605-612 （通讯作者） （7）Shi Y, Sandoghchian Shotorbani S, Su Z, Liu Y, Tong J, Zheng D, Chen J, Liu Y, Xu Y, Jiao Z, Wang S, Lu L, Huang X, Xu H. Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis. Clin Dev Immunol. 2012;2012:295081. （通讯作者） （8）Jiang Y, Chen R, Shao X, Ji X, Lu H, Zhou S, Zong G, Xu H, Su Z. HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming. Int Immunopharmacol. 2018;56:277-284（通讯作者） （9）Zhao Y, Shao Q, Zhu H, Xu H, Long W, Yu B, Zhou L, Xu H, Wu Y, Su Z. Resveratrol ameliorates Lewis lung carcinoma-bearing mice development, decreases granulocytic myeloid-derived suppressor cell accumulation and impairs its suppressive ability. Cancer Sci. 2018;109(9):2677-2686. （通讯作者） （10）Su Z, Wang T, Zhu H, Zhang P, Han R, Liu Y, Ni P, Shen H, Xu W, Xu H. HMGB1 modulates Lewis cell autophagy and promotes cell survival via RAGE-HMGB1-Erk1/2 positive feedback during nutrient depletion. Immunobiology. 2015;220(5):539-44 （11）Su Z, Sun Y, Zhu H, Liu Y, Lin X, Shen H, Chen J, Xu W, Xu H.Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis. Immunol Res. 2014;58(1):118-24. 9 （12）Lu H, Zong G, Zhou S, Jiang Y, Chen R, Su Z, Wu Y. Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. Microbiol Immunol. 2017;61(12):539-546.