教育背景
2010.10至2014.10 瑞典皇家工学院 (KTH-Royal Institute of Technology) 有机化学系博士
2007.09至2010.06 暨南大学药学院药物化学专业硕士
2003.09至2007.06 湖南师范大学制药工程专业学士
工作经历
2017.04至今 江苏大学药学院 教授
2014.12至2016.08 美国俄亥俄州立大学化学系 博士后研究员
项目课题经历
江苏省自然科学基金青年项目
江苏省双创博士项目
江苏大学高级人才启动基金
论文、成果、著作等
代表性科研成果:
Xu, J., Hu, L.*, Asymmetric One-pot Synthesis of Five- and Six-membered Lactones via Dynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase. Tetrahedron Lett., 2019, 60(12), 868.
Ren, Y., Hu, L., Ramström, O.*, Multienzymatic Cascade Synthesis of an Enantiopure (2R,5R)-1,3-Oxathiolane anti-HIV Agent Precursor. Mol. Catal., 2019, 468, 52.
Pratumyot, Y.; Chen, S.; Hu, L.; Polen, M. S.; Hadad, M. C.; Badjić, D. B. Assembly and folding of twisted baskets in organic solvents, Org. Lett., 2016, 18, 4238.
Hu, L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badjić, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets. Eur. J. Org. Chem., 2015, 31, 6832.
Hu, L.; Zhang, Y.; Ramström, O. Gelation-driven Dynamic Systemic Resolution: in situ Generation and Self-Selection of an Organogelator. Sci. Rep., 2015, 5, 11065.
Hu, L.; Ren, Y., Ramström, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes. J. Org. Chem., 2015, 80, 8478.
Schaufelberger, F.; Hu, L.; Ramström, O. trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions. Chem. Eur. J., 2015, 21, 9776.
Hu, L.; Ramström, O. Silver-catalyzed dynamic systemic resolution of α-iminonitriles in a 1,3-dipolar cycloaddition process. Chem. Commun., 2014, 50, 3792.
Hu, L.; Zhang, Y.; Ramström, O. Lipase-catalyzed asymmetric synthesis of oxathiazinanones through dynamic covalent kinetic resolution. Org. Biomol. Chem., 2014, 12, 3572.
Hu, L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramström, O. Dynamic constitutional chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014. DOI: 10.1002/0471238961.consrams.a01
Zhang, Y.; Hu, L.; Ramström, O. Constitutional dynamic chemistry for Bioactive Compounds. In: Supramolecular systems in biomedical fields. (Ed.: H.-J. Schneider) RSC, UK, 2013. (书籍章节)
Hu, L.; Schaufelberger, F.; Zhang, Y.; Ramström, O. Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution. Chem. Comm. 2013, 49, 10376.
Zhang, Y.; Hu, L.; Ramström, O. Double Parallel Dynamic resolution through lipase-catalyzed asymmetric transformation. Chem. Comm. 2013, 49, 1805.
Hu, L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. Eur. J. Med. Chem., 2010, 45, 5943.
Wang, Y-T‡ ; Hu, L‡ ; Chen W-M; Hu A-X; Song, Q-L; Guan D. Synthesis and antibacterial activities of (9S)-3-O-descladinose-6-O-methyl-3-oxo-12-(Δ2- pyrazolinyl)-12-dehydroxy-21-demethyl-9-dihydro-erythromycin A. Lett. Org. Chem., 2009,6, 306. ‡ 共同第一作者
专利、著作版权等
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