2004.09-2008.06，中国药科大学，制药工程，学士 2008.09-2013.06，中国药科大学，药物化学，博士，导师：彭司勋、张奕华 2013.08-2015.08，美国佛罗里达大学，博士后

2015.12-2018.12，南京医科大学，药学院，副教授，硕导 2019.01至今，江南大学，生物工程学院，副教授，硕导

1. 国家自然科学基金青年项目，81602960，靶向性一氧化氮供体型铁螯合剂的设计、合 成和抗肿瘤活性研究，2017.01—2019.12，20万元 2. 江苏省自然科学基金青年项目，BK20161028，具

1. Fu, J.; Han, J.; Meng, T.; Hu, J.; Yin, J. Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity. Chem. Commun. 2019, 55, 12904-12907. (IF 6.16) 2. Meng, T.; Han, J.; Zhang, P.; Hu, J.; Fu, J.*; Yin, J.* Introduction of the α-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs. Chem. Sci. 2019, 10, 7156-7162. (IF 9.56) 3. Han, J.; Meng, T.; Chen, X.; Han, Y.; Fu, J.*; Zhou, F.; Fei, Y.; Li, C.* The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogues xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models. FASEB J. 2019, 33, 7113-7125. (IF = 5.39) 4. Han, J.*; Chen, X.; Zhao, L.; Fu, J.*; Sun, L.; Zhang, Y.; Zhou, F.; Fei, Y. Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs. Mol. Pharm. 2018, 15, 2840-2856. (IF 4.40) 5. Han, J.*; Zhou, F.; Fei, Y.; Chen, X.; Fu, J.*; Qian, H.* Preparation and Pharmaceutical Characterizations of Lipidated Dimeric Xenopus Glucagon-Like Peptide-1 Conjugates. Bioconjug. Chem. 2018, 29, 390-402. (IF 4.35) 6. Han, J.*; Fei, Y.; Zhou, F.; Chen, X.; Zhang, Y.; Liu, L.; Fu, J.* Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities. Br. J. Pharmacol. 2018, 175, 544-557. (IF 6.58) 7. Huang, Z.; Fu, J. (co-first author); Zhang, Y., Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects. J. Med. Chem. 2017, 60, 7617-7635. (IF 6.05) 8. Han, J.*; Wang, Y.; Meng, Q.; Li, G.; Huang, F.; Wu, S.; Fei, Y.; Zhou, F.; Fu, J.*, Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. Eur. J. Med. Chem. 2017, 132, 81-89. (IF 4.83) 9. Han, J.*; Fei, Y.; Zhou, F.; Chen, X.; Zheng, W.; Fu, J.*, Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes. Mol. Pharm. 2017, 14, 3954-3967. (IF 4.40) 10. Han, J.*; Chen, X.; Wang, Y.; Fei, Y.; Zhou, F.; Zhang, Y.; Liu, L.; Si, P.; Fu, J.*, Xenopus GLP-1inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. Biochem. Pharmacol. 2017, 142, 155-167. (IF 4.83)

申请中国专利7件，授权1件