2006,09-2010,07 兰州大学 生命科学学院 生物技术专业 学士 2010,09-2013,07 兰州大学 生命科学学院 肿瘤生物学与新药筛选研究所硕士 2013,11-2017,11 荷兰乌特勒支大学 药学院 博士

2017,12-2018,12 葛兰素史克(西班牙)研发中心 2019,01-至今 江南大学 生物工程学院 副研究员

[1] Shi, J., R. Ruijtenbeek, and R.J. Pieters. (2018). Demystifying O-GlcNAcylation: hints from peptide substrates. Glycobiology, 28(11): p. 814-824 [2] Shi, J., Tomasic, T., Sharif, S., Brouwer, A. J., Anderluh, M., Ruijtenbeek, R., and Pieters, R. J. (2017). Peptide microarray analysis of the cross-talk between O-GlcNAcylation and tyrosine phosphorylation, FEBS Lett. 591, 1872-1883. [3] Shi, J., S. Sharif, R. Ruijtenbeek and R. J. Pieters. (2016). Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS One 11(3): e0151085. [4] Sharif S, Shi J, Ruijtenbeek R, Pieters RJ. (2019). Study of cross talk between phosphatases and OGA on a ZO-3-derived peptide. Amino Acids. (出版中) [5] Zhang, H., Tomašič, T., Shi, J., Weiss, M., Ruijtenbeek, R., Anderluh, M., and Pieters, R.J. (2018). Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids. MedChemComm 9(5): p. 883-887. [6] Sharif, S., Shi, J., Bourakba, M., Ruijtenbeek, R., and Pieters, R. J. (2017). Measuring O-GlcNAc cleavage by OGA and cell lysates on a peptide microarray, Anal. Biochem. 532, 12-18. [7] Shi, J., J. Chen, N. Serradji, X. Xu, H. Zhou, Y. Ma, Z. Sun, P. Jiang, Y. Du, J. Yang, C. Dong and Q. Wang. (2013). PMS1077 sensitizes TNF-alpha induced apoptosis in human prostate cancer cells by blocking NF-kappaB signaling pathway. PLoS One 8(4): e61132. [8] He, J., J. Shi, X. Xu, W. Zhang, Y. Wang, X. Chen, Y. Du, N. Zhu, J. Zhang, Q. Wang and J. Yang, (2012). STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signaling pathway. J Biosci 37(2): 243-257. [9] Lei Jia*, Jie Shi, Zhihong Sun, Feifei Li, Yuan Wang, Weina Wu and Qin Wang*, (2012). Synthesis, crystal structure, DNA-binding properties, cytotoxic and antioxidation activities of several ternary copper (II) complexes with a new reduced Schiff base ligand, Inorganica Chimica Acta. 391, 121–129.