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赵鑫锐

领域:生物产业 学校:江南大学职称:副教授

长期从事酵母以及大肠杆菌代谢工程的研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2002-2006 安徽大学,生物科学专业,理科学士 2007-2010 安徽大学,微生物学专业,理科硕士 2010-2014 江南大学,发酵工程专业,工科博士

工作经历

2014-2016 江南大学,糖化学与糖药物工程研究室,博士后 2016-2018 韩国KAIST大学,Metabolic & Biomolecular Engineering Laboratory,博士后

项目课题经历

论文、成果、著作等

1. Zhao, X., Choi, K., Lee, S. *, Metabolic engineering of Escherichia coli for secretory production of free haem. Nat. Catal. doi: 10.1038/s41929-018-0126-1. 2. Zhao, X., Park, S., Yang. D., Lee, S. *, Synthetic biology for natural compounds. Biochemistry doi: 10.1021/acs.biochem.8b00569 (IF: 2.99). 3. Yang, M., Hong, H., Liu, S., Zhao, X., Wu, Z. *, 2018. Immobilization of Staphylococcus aureus sortase A on chitosan particles and its applications in peptide-to-peptide ligation and peptide cyclization. Molecules 23 (1), 192 (IF: 3.10) 4. Zhao, X., Hong, H., Cheng, X., Liu, S., Deng, T., Guo, Z., Wu, Z. *, 2017. One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst. Sci. Rep. 7, doi: 10.1038/s41598-017-06856-y. (IF: 4.26) 5. Zhao, X., Hong, H., Wu, Z. *, 2017. Efficient extracellular expression of transpeptidase sortase A in Pichia pastoris. Protein Expr. Purif. 133, 132-138. (IF: 1.35) 6. Wu, Z. *, Hong, H., Zhao, X., Wang, X., 2017. Efficient expression of sortase A from Staphylococcus aureus in Escherichia coli and its enzymatic characterizations. Bioresour. Bioprocess. 4, 13. 7. Wu, Z. *, Liu, S., Cheng, X., Zhao, X., Hong, H., 2017. High yield synthesis of cyclic analogues of antibacterial peptides P-113 by Sortase A-mediated ligation and their conformation studies. Chin. Chem. Lett. 28, 553-557. (IF: 1.93) 8. Wu, Z. *, Cheng, X., Hong, H., Zhao, X., Zhou, Z., 2017. New potent and selective alpha v beta(3) integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation. Biorg. Med. Chem. Lett. 27, 1911-1913. (IF: 2.45) 9. Zhao, X., Zou, H., Chen, J., Du, G., Zhou, J. *. 2016. The modification of Gat1p in nitrogen catabolite repression to enhance non-preferred nitrogen utilization in Saccharomyces cerevisiae. Sci. Rep. 6, doi:10.1038/srep21603. (IF: 5.23)10. Zhao, X., Zou, H., Du, G., Chen, J., Zhou, J. *. 2015. Effects of nitrogen catabolite repression-related amino acids on the flavour of rice wine. J. I. Brewing 121:581-588. (IF: 1.02) 11. Zhao, X., Zou, H., Fu, J., Zhou, J. *, Du, G. *, Chen, J.. 2014. Metabolic engineering of the regulators in nitrogen catabolite repression to reduce the production of ethyl carbamate in a model rice wine system. Appl. Environ. Microbiol. 80:392-398. (IF: 3.95) 12. Zhao, S., Zhao, X., Zou, H., Fu, J., Du, G. *, Zhou, J. *, Chen, J.. 2014. Comparative proteomic analysis of Saccharomyces cerevisiae under different nitrogen sources. J. Proteomics 101:102-112. (IF: 4.09) 13. Zhao, X., Zou, H., Fu, J., Chen, J., Zhou, J. *, Du, G. *. 2013. Nitrogen regulation involved in the accumulation of urea in Saccharomyces cerevisiae. Yeast 30:437-447. (IF: 1.96) 14. Zhao, X., Du, G. *, Zou, H., Fu, J., Zhou, J.*, Chen, J.. 2013. Progress in preventing the accumulation of ethyl carbamate in alcoholic beverages. Trends Food Sci. Technol. 32:97-107. (IF: 4.14) 15. Lv, Y., Zhao, X., Liu, L., Du, G. *, Zhou, J. *, Chen, J.. 2013. A simple procedure for protein ubiquitination detection in Saccharomyces cerevisiae: Gap1p as an example. J. Microbiol. Meth. 94:2529. (IF: 2.16)

专利、著作版权等

1. 吴志猛,赵鑫锐,洪皓飞. 一种高效分泌表达转肽酶Sortase A的方法. 专利申请号: 201510430763.4 2. 吴志猛,赵鑫锐,洪皓飞,王珣. 一种利用重组大肠杆菌高效生产转肽酶Sortase A的方法. 专利 申请号:201510440032.8 3. 周景文,陈坚,堵国成,吕永坤,赵鑫锐.一种改造调控因子降低酵母尿素积累的方法. 专利申 请号:201510810669.1 4. 周景文,陈坚,堵国成,吕永坤,赵鑫锐.一种可降低黄酒发酵中氨基甲酸乙酯积累的方法. 专 利申请号:201510812131.4 5. 周景文,陈坚,堵国成,吕永坤,赵鑫锐.一种改造尿素代谢调控途径降低酿酒酵母尿素积累的 方法. 专利申请号:201510816366.0 6. 周景文,陈坚,堵国成,吕永坤,赵鑫锐.一种提高酿酒酵母非偏好型氮源利用的方法. 专利申 请号:201510819223.5
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