2008-2013 华东理工大学，生物化工专业，工学博士 2004-2008 山东农业大学，生物工程专业，工学学士

2014-至今 江南大学，生物工程专业，副教授

1、国家重点研发计划“合成生物学”重点专项（2019YFA0906400），子课题负责人，2020-2024； 2、江苏省自然科学基金面上项目（BK20171135），负责人，2017-2020； 3、国家自然科学基金面上项目（21776112），主要参与人，2018-2021； 4、国家自然科学基金青年项目(21506073)，负责人，已结题。

1. 第一作者及通讯作者(近五年) [1] Xu GC, Dai W, Wang Y, Zhang L, Sun ZW, Zhou JY, Ni Y, Molecular switch manipulating Prelog priority of an alcohol dehydrogenase toward bulky-bulky ketones, Molecular Catalysis, 2020, 484, 110741. [2] Xu GC, Zhu C, Jia P, Li AT, Ni Y, Han RZ, Zhou JY, Ni Y, Engineering an Alcohol Dehydrogenase for Balancing kinetics in NADPH Regeneration with 1,4-Butanediol as a Greener Cosubstrate, ACS Sustainable Chemistry & Engineering, 2019, 7, 15706-15714. [3] Xu GC, Wu AN, Xiao L, Han RZ, Ni Y, Enhancing butanol tolerance of Escherichia coli reveals hydrophobic interaction of multi-tasking chaperone SecB, Biotechnology for Biofuels, 2019, 12, 164. [4] Xu GC, Wang Y, Tang MH, Zhou JY, Zhao J, Han RZ, Ni Y, Hydroclassified combinatorial saturation mutagenesis: reshaping substrate binding pockets of KpADH for enantioselective reduction of bulky-bulky ketones, ACS Catalysis, 2018, 8, 8336-8345. [5] Xu GC, Yu HL, Zhang XY, Xu JH, Access to optically active aryl halohydrins using a substratetolerant carbonyl reductase discovered from Kluyveromyces thermotolerans, ACS Catalysis, 2012, 2, 2566 –2571. [6] Xu GC, Yu HL, Zhang ZJ, Xu JH, Stereocomplementary bioreduction of β-ketonitrile without ethylated byproduct, Organic Letters, 2013, 15, 5408–5411. [7] Xu GC, Shang YP, Yu HL, Xu JH, Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins, Chemical Communications, 2015, 51, 15728–15731. [8] Xu GC, Zhang YP, Wang Y, Ni Y, Genome hunting of carbonyl reductases from Candida glabrata for efficient preparation of chiral secondary alcohols, Bioresource Technology, 2018, 247, 553-560.[9] Xu GC, Ding JC, Han RZ, Dong JJ, Ni Y, Enhancing cellulose accessibility of corn stover by deep eutectic solvent pretreatment for butanol fermentation, Bioresource Technology, 2016, 203, 364–369. [10] Zhang Y, Pan J, Luan ZJ, Xu GC, Park S, Xu JH, Cloning and Characterization of a Novel Esterase from Rhodococcus sp. for Highly Enantioselective Synthesis of a Chiral Cilastatin Precursor, Applied and Environmental Microbiology, 2014, 80, 7348–7355. [11] Wang Y, Dai W, Liu YM, Zhang ZW, Zhou JY, Xu GC, Ni Y, Fine tuning the enantioselectivity and substrate specificity of alcohol dehydrogenase from Kluyveromyces polysporus by single residue at 237, Catalysis Communications, 2018, 108, 1-6. [12] Xu GC, Yu HL, Shang YP, Xu JH, Enantioselective bioreductive preparation of chiral halohydrins employing two newly identified stereocomplementary reductases, RSC Advances, 2015, 5, 22703–22711. [13] Xu GC, Zhang LL, Ni Y, Enzymatic preparation of D-phenyllactic acid at high space-time yield with a novel phenylpyruvate reductase identified from Lactobacillus sp CGMCC 9967, Journal of Biotechnology, 2016, 222, 29–37. [14] Xu GC, Yu HL, Xu JH, Facile Access to Chiral Alcohols with Pharmaceutical Relevance Using a Ketoreductase Newly Mined from Pichia guilliermondii, Chinese Journal of Chemistry, 2013, 31, 349– 354. [15] Xu GC, Tang MH, Ni Y, Asymmetric synthesis of lipitor chiral intermediate using a robust carbonyl reductase at high substrate to catalyst ratio, Journal of Molecular Catalysis B:Enzymatic, 2016, 123, 67– 72. [16] Xu GC, Li L, Han RZ, Dong JJ, Ni Y, Characterization and soluble expression of D-hydantoinase from Pseudomonas fluorescens for the synthesis of D-amino acids, Applied Biochemistry and Biotechnology, 2016, 1, 1–15. [17] Xu GC, Bian YQ, Han RZ, Dong JJ, Ni Y, Cloning, expression, and characterization of budC gene encoding meso-2,3-butanediol dehydrogenase from Bacillus licheniformis, Applied Biochemistry and Biotechnology, 2016, 178, 604–617. 2. 指导学生发表论文(近五年) [1] Ni J, Xu GC, Dai W, Zhao YL, Ni Y, Hyperconjugation promoted by hydrogen bonding between His98/His241 and a carboxyl group contributes to tyrosine decarboxylase catalysis, Catalysis Science & Technology, 2019, 9, 6222-6226. [2] Gong L, Xu ZY, Dong JJ, Li H, Han RZ, Xu GC, Ni Y, Composite coal fly ash solid acid catalyst in synergy with chloride for biphasic preparation of furfural from corn stover hydrolysate, Bioresource Technology, 2019, 293, 122065. [3] Jiang MY, Xu GC, Ni J, Zhang K, Dong JJ, Han RZ Ni Y, Improving Soluble Expression of Tyrosine Decarboxylase from Lactobacillus brevis for Tyramine Synthesis with High Total Turnover Number, Applied Biochemistry & Biotechnology, 2019, 188, 436-439. [4] Zhou JY, Wang Y, Xu GC, Wu L, Han RZ, Schwaneberg U, Rao YJ, Zhao YL, Zhou JH, Ni Y, Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a ‘polar gate’ in stereorecognition of diaryl ketones, Journal of the American Chemical Society, 2018, 140, 12645-12654. [5] Xing WR, Xu GC, Dong JJ, Han RZ, Ni Y, Novel dihydrogen-bonding deep eutectic solvents: Pretreatment of rice straw for butanol fermentation featuring enzyme recycling and high solvent yield, Chemical Engineering Journal, 2018, 333, 712-720. [6] Zhang WX, Xu GC, Huang L, Pan J, Yu HL, Xu JH, Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g·L–1·d–1 using a new bacterial reductase ArQR, Organic Letters, 2013, 15, 4917–4919. [7] Liu YF, Xu GC, Han RZ, Dong JJ, Ni Y, Identification of D-carbamoylase for biocatalytic cascade synthesis of D-tryptophan featuring high enantioselectivity, Bioresource Technology, 2018, 249, 720-728. [8] Ding JC, Xu GC, Han RZ, Ni Y, Biobutanol production from corn stover hydrolysate pretreated with recycled ionic liquid by Clostridium saccharobutylicum DSM 13864, Bioresource Technology, 2016, 199, 228–234. [9] Zhou JY, Xu GC, Han RZ, Dong JJ, Zhang WG, Zhang RZ, Ni Y, Carbonyl group-dependent highthroughput screening and enzymatic characterization of diaromatic ketone reductase, Catalysis Science & Technology, 2016, 6, 6320–6327. [10] Gong Y, Xu GC, Chen Q, Yin JG, Li CX, Xu JH, Iterative multitarget evolution dramatically enhances the enantioselectivity and catalytic efficiency of Bacillus subtilis esterase towards bulky benzoate esters of DL-menthol, Catalysis, Science & Technology, 2016, 6, 2370–2376. [11] Zhu HX, Xu GC, Zhang K, Kong XD, Han RZ, Zhou JH, Ni Y, Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding, Scientific Reports, 2016, 6, 27779. [12] Han RZ, Xu GC, Dong JJ, Ni Y, Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug, Applied Microbiology and Biotechnology, 2016, 100, 4747–4760. [13] Cheng J, Xu GC, Han RZ, Dong JJ, Ni Y, Efficient access to L-phenylglycine using a newly identified amino acid dehydrogenase from Bacillus clausii, RSC Advances, 2016, 6, 80557–80563. [14] Fan CW, Xu GC, Ma BD, Bai YP, Zhang J, Xu JH, A novel D-mandelate dehydrogenase used in three-enzyme cascade reaction for highly efficient synthesis of non-natural chiral amino acids, Journal of Biotechnology, 2015, 195, 67–71. [15] Gong Y, Xu GC, Zheng GW, Li CX, Xu JH, Journal of Molecular Catalysis B:Enzymatic, 2014, 109, 1–8. [16] Xue TY, Xu GC, Han RZ, Ni Y, Soluble expression of (+)-gamma-lactamase in Bacillus subtilis for the enantioselective preparation of Abacavir precursor, Applied Biochemistry and Biotechnology, 2015, 176, 1687–1699. [17] Yin JG, Xu GC, Zheng GW, Xu JH, Cloning and characterization of an enantioselective l-menthyl benzoate hydrolase from Acinetobacter sp ECU2040, Applied Biochemistry and Biotechnology, 2015, 176, 1102–1113.

共申请国内专利15件，授权国内专利3件，申请国际专利4件。