2011.09-2015.01 江南大学生物工程学院 博士 2008.09-2011.07 福建农林大学生命科学学院 硕士 2004.09-2008.07 江西理工大学材料与化学工程学院 学士 其中： 2016.02-至今 寿光巨能玉米开发有限公司 博士后

2017.06-至今 江南大学生物工程学院 副教授 2015.01-2017.06 江南大学生物工程学院 讲师

近3年来承担本科生（包括生物工程专业、生物技术专业、酿酒专业和基地班）专业 选修课程《氨基酸工艺学》的教学工作；主持国家自然科学基金、中国博士后科学基 金、江苏省自然科学基金和教育部重点实验室开放课题5项，参与横向课题1项。 其中代表性的科研项目如下: [1] 国家自然科学基金-青年基金项目（31601459）：总经费：20万；到账经费：12万 [2] 中国博士后基金-一等资助（1014130201160140）：总经费：8万；到账经费：8万 [3] 江苏省自然科学基金-青年基金项目（BK20150149）：总经费：20万；到账经费： 20万

[1] Jian Z. Xu(*), Hao Z. Ruan, Hai B. Yu, Li M. Liu, and Wei G. Zhang, Metabolic engineering of carbohydrate metabolism systems in Corynebacterium glutamicum for improving the efficiency of L-lysine production from mixed sugar, Microbial Cell Factories, 2020, 19(0):39-44. Doi: 10.1186/s12934-020-1294-7 [2] Jian Z. Xu(*), Hai B. Yu, Mei Han, Xiu L. Chen, and Wei G. Zhang, Metabolic engineering of glucose uptake systems in Corynebacterium glutamicum for improving the efficiency of L-lysine production, Journal of Industrial Microbiology & Biotechnology, 2019, 46(7):937-949. Doi: 10.1007/s10295-019-02170-w [3] Ying Y. Wang, Jian Z. Xu(*), and Wei G. Zhang(*), Metabolic engineering of L-leucine production in Escherichia coli and Corynebacterium glutamicum: a review, Critical Reviews in Biotechnology, 2019, 39(5):633-647. Doi: 10.1080/07388551.2019.1577214 [4] Ying Y. Wang, Feng Zhang, Jian Z. Xu(*),Wei G. Zhang(*), Xiu L. Chen, and Li M. Liu, Improvement of L-leucine production in Corynebacterium glutamicum by altering the redox flux, International Journal of Molecular Sciences, 2019, 20(8):2020-2034. Doi: 10.3390/ijms20082020 [5] Jian Z. Xu(*), Hao Z. Ruan, Xiu L. Chen, Feng Zang, and Wei G. Zhang, Equilibrium of the intracellular redox state for improving cell growth and L-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping, Microbial Cell Factories, 2019, 18:65-76. Doi: 10.1186/s12934-0191114-0 [6] Jian Z. Xu(*), Hao Z. Ruan, Li M. Liu, Lu P. Wang, and Wei G. Zhang, Overexpression of thermostable meso-diaminopimelate dehydrogenase to redirect diaminopimelate pathway for increasing L-lysine production in Escherichia coli, Scientific Reports, 2019, 9:2423-2436. Doi: 10.1038/s41598018-37974-w [7] Xian Zhang, Zhao Y. Xu, Song Liu, Kai Qian, Mei J. Xu, Tao W. Yang, Jian Z. Xu(*), and Zhi M. Rao(*), Improving the production of salttolerant glutaminase by integrating multiple copies of Mglu into the protease and 16S rDNA genes of Bacillus subtilis 168, Molecules, 2019, 24(3): 592-604. Doi: 10.3390/molecules24030592 [8] Xian Zhang, Man C. Zhu, Ru M. Han, You X. Zhao, Ke W. Chen, Kai Qian, Ming L. Shao, Tao W. Yang, Mei J. Xu, Jian Z. Xu(*),and Zhi M. Rao(*), A novel 3-phytosterone-9α-hydroxylase oxygenation component and its application in bioconversion of 4-androstene-3,17-sione to 9αhydroxy-4-androstene-3,17-dione coupling with a NADH regeneration formate dehydrogenase, Molecules, 2019, 24(0): 2534-2546. Doi: 10.3390/molecules24142534 [9] Jian Z. Xu(*), Han K. Yang, and Wei G. Zhang, NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis. Critical Reviews in Biotechnology, 2018, 38(7):1061-1076. Doi: 10.1080/07388551.2018.1437387 [10] Jian Z. Xu(*), Han K. Yang, Li M. Liu, Ying Y. Wang, and Wei G. Zhang, Rational modification of Corynebacterium glutamicum dihydrodipicolinate reductase to switch the nucleotide-cofactor specificity for increasing L-lysine production. Biotechnology and Bioengineering, 2018, 115:1764-1777. Doi: 10.1002/bit.26591 [11] Jian Z. Xu(*), Ze H. Wu, Shi J. Gao(*), and Wei G. Zhang, Rational modifcation of tricarboxylic acid cycle for improving L-lysine production in Corynebacterium glutamicum. Microbial Cell Factories, 2018, 17:105-118. Doi: 10.1186/s12934-018-0958-z [12] Jian Z. Xu(*), Jun L. Zhang, and Wei G. Zhang, Antisense RNA: the new favorite in genetic research. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2018, 19(10):739-749. Doi: 10.1631/jzus.B1700594 [13] Li Y. Feng, Jian Z. Xu(*), and Wei G. Zhang(*), Improved L-leucine production in Corynebacterium glutamicum by optimizing the aminotransferases. Molecules, 2018, 23: 2102-2115. Doi: 10.3390/molecules23092102 [14] Mei Han, Jian Z. Xu(*), Zhen M. Liu, He Qian, and Wei G. Zhang, Co-production of microbial oil and exopolysaccharide by the oleaginous yeast Sporidiobolus pararoseus grown in fed-batch culture, RSC Advances, 2018, 8:3348-3356. Doi: 10.1039/c7ra12813d

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