2001-2005 江南大学，生物工程专业，工学学士 2005-2012 江南大学，发酵工程专业，工学博士

2012-至今 江南大学，生物工程学院，副教授

1. 国家自然科学基金青年科学基金：基于高细胞密度的大肠杆菌动态调控新模式 （31300087），主持。 2. 江苏省自然科学基金：新型大肠杆菌动态代谢调控系统的构建（BK20130131），主 持。 3. 江南大学自主科研课题重点项目：大肠杆菌生产四碳有机酸的细胞工厂构建 （1012050205162440），主持子课题。 4. 江南大学自主科研课题：自感应联动调控系统的构建及其在协调细胞活性和乳酸合 成中的作用（JUSRP1004），主持。 5. 教育部重点实验室开放课题：内含肽介导成熟的谷氨酰胺转氨酶的可控廉价制备 （KLIB-KF201203），主持。 6. 国家重点研发计划-政府间国际科技创新合作项目：高活性和高稳定性新型腈水合酶 的开发和应用（2016YFE012740），参与。 7. 国家863计划：重组高分泌型枯草芽孢杆菌重组表达系统的开发与规模化应用 （2014AA021304），参与。 8. 国家自然科学基金青年科学基金：Bacillus subtilis双精氨酸转运系统中信号肽定向识 别的分子机制（31400058），参与。 9. 江苏省自然科学基金：枯草芽孢杆菌氨肽酶PA domain的功能研究 （BK20140151），参与。 10. 江苏省产学研联合创新基金项目：纳豆激酶的开发与高效制备（BY2014023-21）， 参与。

1. Li Zhou, Wen-Jing Cui, Zhong-Mei Liu, Zhe-Min Zhou. Metabolic engineering strategies for D-lactate over production in Escherichia coli. Journal of Chemical Technology and Biotechnology, 2016, 91: 576-584 2. Li Zhou, Can Deng, Wen-Jing Cui, Zhong-Mei Liu, Zhe-Min Zhou. Efficient L-alanine production by a thermo-regulated switch in Escherichia coli. Applied Biochemistry and Biotechnology, 2016, 178: 324-337 3. Longbao Zhu, Li Zhou (co-first author), Nan Huang, Wen-Jing Cui, Zhong-Mei Liu, Ke Xiao, Zhe-Min Zhou. Efficient preparation of enantiopure D-phenylalanine through asymmetric resolution using immobilized phenylalanine ammonia-lyase from Rhodotorula glutinis JN-1 in a recirculating packed-bed reactor. PLoS ONE, 2014, 9: e108586 4. Longbao Zhu, Li Zhou (co-first author), Wen-Jing Cui, Zhong-Mei Liu, Zhe-Min Zhou. Mechanism-based site-directed mutagenesis to shift the optimum pH of the phenylalanine ammonia-lyase from Rhodotorula glutinis JN-1. Biotechnology Reports, 2014, 3: 21-26 5. Kun Du, Zong-Mei Liu, Wen-Jing Cui, Li Zhou, Yi Liu, Guo-Cheng Du, Jian Chen, ZheMin Zhou. A pH-dependent activation of Streptomyces hygroscopicus transglutaminase mediated by intein. Applied & Environmental Microbiology, 2014, 80: 723-729 6. Xian-Zhong Chen, Li Zhou, Kang-Ming Tian, Ashwani Kumar, Suren Singh, Bernard Prior, Zheng-Xiang Wang. Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production. Biotechnology Advance, 2013, 31: 1200-1223 7. Li Zhou, Xian-Zhong Chen, Dan-Dan Niu, Kang-Ming Tian, Bernard A. Prior, Wei Shen, Gui-Yang Shi, Suren Singh, Zheng-Xiang Wang. Genetically switched D-lactate production in Escherichia coli. Metabolic Engineering, 2012, 14: 560-568 8. Li Zhou, Wei Shen, Dan-Dan Niu, Kang-Ming Tian, Bernard A. Prior, Gui-Yang Shi, Suren Singh, Zheng-Xiang Wang. Fine tuning the transcription of ldhA for D-lactate production. Journal of Industrial Microbiology & Biotechnology, 2012, 39: 1209-1217 9. Li Zhou, Kang-Ming Tian, Dan-Dan Niu, Wei Shen, Gui-Yang Shi, Suren Singh, ZhengXiang Wang. Improvement of D-lactate productivity in recombinant Escherichia coli by coupling production with growth. Biotechnology Letters, 2012, 34: 1123-1130 coupling production with growth. Biotechnology Letters, 2012, 34: 1123-1130 10. Li Zhou, Zhi-Rui Zuo, Xian-Zhong Chen, Dan-Dan Niu, Kang-Ming Tian, Bernard A. Prior, Wei Shen, Gui-Yang Shi, Suren Singh, Zheng-Xiang Wang. Evaluation of genetic manipulation strategies on D-lactate production by Escherichia coli. Current Microbiology, 2011, 62: 981-989

1. A fused NHase with improved specific activity and stability，US9896679B2。 2. A fused NHase with improved specific activity and stability，US9670474B2。 3. 一种启动子及其应用，ZL201510203088.1。 4. 一种比酶活和稳定性提高的融合型腈水合酶，ZL201510195795.0。