教育背景
2000.09—2004.07 新疆大学,生物技术专业,理学学士 2004.09—2007.07 新疆大学,生物化学与分子生物学,理学硕士 2007.09—2011.12 江南大学和 Imperial College London 联合培养博士,发酵工程专业, 工学博士 其中: 2009.02—2010.10 Imperial College London(Glycoscience laboratory),医药学院
工作经历
2011.12—2012.03 University of Missouri,生物工程学院,访问学者 2012.03—2016.09 江南大学,校聘副教授 2016.09— 江南大学,副教授 2018.01—2019.01 Uinversity of North Carolina,Chapel Hill(Glycoscience laboratory),访问学者
项目课题经历
1、主持国家自然科学基金面上项目:具有光交联和蛋白“质谱标签”转化功能的寡糖探 针构建及其在"糖链-活体膜蛋白"相互作用研究中的应用,项目编号:21778022 2、主持国家自然科学基金青年项目:基于量子点/NBD 荧光比率的高灵敏、高通量功能寡 糖筛选和构效关系评估体系构建及其应用,项目编号:31201384 3、主持国家博士后基金特别资助项目:唾液酸化寡糖的规模化耦合催化合成体系构建研 究 项目编号:2014T70472 4、主持国家博士后基金面上项目:唾液酸化寡糖新型耦合催化合成体系的构建及其应用 研究 项目编号:2012M520996 5、主持江苏省博士基金:人源稀有功能唾液酸化寡糖的微生物合成及其构效关系研究, 项 目编号:1301011B 6、主持江苏省省资助博士后项目:人源稀有功能唾液酸化寡糖的微生物合成及其构效关 系研究 7、第二主持人国家自然科学基金面上项目:微生物β-葡聚寡糖最小功能单元的挖掘及其 构效关系研究, 项目编号:3117164 8、参与十三五重大研发项目支项目:我国传统膳食营养组学及肠道微生物组大数据分析, 项目编号:2017YFD0400302
论文、成果、著作等
1、Xiaobei Zhan, Zhang Hongtao. (2017). Chapter 3. Curdlan oligosaccharides: Production and Application. Functional Carbohydrates, Taylor & Francis 2、Zhang, H.T, Palma, A. S., Zhang, Y., Childs, R. A., Liu, Y., Mitchell, D. A., & Feizi, Ten. (2016). Generation and characterization of β1, 2-gluco-oligosaccharide probes from Brucella abortus cyclic β-glucan and their recognition by C-type lectins of the immune system. Glycobiology, 26(10), 1086-1096. 3、Palma, A. S., Liu, Y., Zhang, H.T, Zhang, Y., McCleary, B. V., Yu, G.,& Wang, D. (2015). Unravelling glucan recognition systems by glycome microarrays using the designer approach and mass spectrometry. Molecular & Cellular Proteomics, mcp-M115. 4、Zhang, H. T., Zhu, L., Liu, D., Zhan, X. B., Ding, J., & Lin, C. C. (2015). Model-based estimation of optimal dissolved oxygen profile in Agrobacterium sp. fed-batch fermentation for improvement of curdlan production under nitrogen-limited condition. Biochemical Engineering Journal, 103, 12-21. 5、Zhang Hongtao, Li, Z., Shuang, Z., & Xiaobei, Z. (2014). Mechanism of Lentinan Hydrolysis Based on ESI-CID-MS/MS and Preparation of Full Series of Oligosaccharides. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 35(11), 2329-2334. 6、Zhang Hongtao, Li, Z., & Xiaobei, Z. (2014). Assignment of Removing Fructose in Reducing Terminal of Nostoc Oligosaccharides Based on ESI-CID-MS/MS and Preparation of Full Series of alpha-1, 2-Gluco-oligosaccharide.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 35(12), 2547-2550. 7、Zhang, H. T., Zhu, L., Zhang, S., Zhan, X. B., & Lin, C. C. (2014). A new, quick, highly sensitive ultramicro-analysis method for the identification of fructose removed from fructofuranosyl-containing gluco-oligosaccharides by ESI-CID-MS/MS. Carbohydrate research, 398, 1-7. 8、Hongtao Zhang, Shuang Zhuang, Guanjun Tao, Yibing Zhang, Xiaobei Zhan, Wengang Cha. (2013) Typing of Blood-Group Antigens of Neutral Oligosaccharides by Negative-Ion Electrospray Ionization Tandem Mass Spectrometry. Analytical Chemistry. 85 (12), pp 5940–5949 9、Zhang, H T, Zhan, X B, Zheng, Z Y, Wu, J R, English, N, Yu, X B, Lin, C C. (2012) Improved curdlan fermentation process based on optimization of dissolved oxygen combined with pH control and metabolic characterization of Agrobacterium sp. ATCC 31749. Appliedl Microbiology and Biotechnology DOI: 10.1007/s00253-011-3448-3 10、Zhang Hong-Tao, Xiaobei Zhan, Joao Carlos Setubal, Zhiyong Zheng. (2011) Sequence and transcriptional analysis of curdlan-producing Agrobacterium sp. ATCC 31749 exposed to dissolved oxygen gradients in a scale-down system. Applied microbiology and biotechnology 91, 163-175 11、Zhang Hong-Tao, Joao Carlos Setubal, Xiaobei Zhan, Zhiyong Zheng, Dingqiang Chen, Jianrong Wu. (2011) Component identification of Electron Transport Chains in Agrobacterium sp. ATCC 31749 and its genome-specific prediction using comparative genome and phylogenetic trees analysis. Journal of Industrial Microbiology and Biotechnology 38, 667-677 12、Xiao-Bei Zhan, Chi-Chung Lin, and Hong-Tao Zhang (2011) Recent advances in curdlan biosynthesis, biotechnological production, and applications. Appllied Microbiology Biotechnology , 93,( 2): 525-531
专利、著作版权等
1、一种β-1,3 葡聚寡糖的寡聚化制备方法,专利编号:CN102660607B 2、一种抑制色素形成的环-1,3-葡聚糖发酵方法 , 专利申请号:201711098454.7
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