2009.08-2014.12，美国韦恩州立大学，化学系，化学博士，导师：郭忠武 2005.08-2009.07，中国科学技术大学，化学系，化学学士，管理学士（双学位）

2016.04-至今，江南大学，生物工程学院，副研究员，硕导（2017年起） 2015.01-2016.04，美国韦恩州立大学，化学系，博士后

主持的项目如下： 1. 国家自然科学基金青年项目，21602084，基于糖代谢工程的化学酶法活细胞表面蛋白探针标 记新策略及其初步应用，2017/01-2019/12, 20万元，在研； 2. 中央高校自主科研计划青年基金，JUSRP11729, 通过化学酶法对糖代谢修饰的活细胞表面进 行蛋白探针标记的研究， 2017/01-2018/12, 8万元，在研； 3. 第63批中国博士后科学基金面上资助二等资助，2018M632227,募集抗体并靶向肿瘤双功能分 子的设计、合成及活性评价， 5万元，在研； 4. 糖化学与生物技术教育部重点实验室开放课题，KLCCB-KF201608, 2016/07-2018/06, 3万 元，在研。

(16) Xiaozhong Cheng, Haofei Hong, Zhifang Zhou, and Zhimeng Wu*, Enzymatic On-Resin Peptide Cleavage and in Situ Cyclization One-Pot Strategy for the Synthesis of Cyclopeptide and Cyclotide, J. Org. Chem. 2018, Oct 2, DOI: 10.1021/acs.joc.8b02032, IF=4.805 (15) Zhifang Zhou, Han Lin, Chen Li, Zhimeng Wu*, Recent progress of fully synthetic carbohydratebased vaccine using TLR agonist as build-in adjuvant, Chinese Chemical Letters, 2018, 29, 19-26. IF=2.631 (14) Zhifang Zhou, Wenzhang Ding, Chen Li, Zhimeng Wu*, Synthesis and immunological study of a wall teichoic acid-based vaccine against E. faecium U0317, Journal of Carbohydrate Chemistry, 2017, 36: 4-6, 205-219 (13) Zhifang Zhou# (contributed equally), Satadru S. Mandal#, Guochao Liao#, Jiatong Guo, Zhongwu Guo*, Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic SelfAdjuvant Cancer Vaccine, Scientific Reports, 2017, 7: 11403, IF=4.122 (12) Xiaozhong Cheng, Tao Zhu, Haofei Hong, Zhifang Zhou, Zhimeng Wu*, Sortase A-mediated onresin peptide cleavage and in situ ligation: an efficient one-pot strategy for the synthesis of functional peptides and proteins, Org. Chem. Front., 2017, 4, 2058-2062. IF=5.455 (11) Jian Gao, Zhifang Zhou, Jiatong Guo, Zhongwu Guo*, Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins, Chem. Commun., 2017, 53, 6227-6230. IF=6.290 (10) Zhimeng Wu*, Xiaozhong Cheng, Haofei Hong, Xinrui Zhao, Zhifang Zhou, New potent and selective avb3 integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase Amediated ligation, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1911-1913 IF=2.422 (9) Guochao Liao#, Zhifang Zhou# (contributed equally), Sharad Suryawanshi, Mohabul A. Mondal, Zhongwu Guo*, Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis, ACS Cent. Sci., 2016, 2, 210-218. IF=11.228 (8) Guochao Liao#, Zhifang Zhou# (contributed equally), Jun Liao, Luning Zu, Qiuye Wu, Zhongwu Guo*, 6-O-Branched Oligo-β-glucan-Based Antifungal Glycoconjugate Vaccines, ACS Infect. Dis., 2016, 2, 123-131 IF=4.325 (7) Zhifang Zhou# (contributed equally), Guochao Liao#, Satadru S. Mandal, Sharad Suryawanshi, Zhongwu Guo*, A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity, Chem. Sci., 2015, 6(12): 7112-7121 IF=9.063 (6) Guochao Liao#, Zhifang Zhou# (contributed equally), Zhongwu Guo*, Synthesis and Immunological Study of α-2,9-Oligosialic Acid Conjugates as Anti-group C Meningitis Vaccines, Chem. Comm., 2015, 51: 9647-9650 IF=6.290 (5) Guochao, Liao, Srinivas Burgula, Zhifang Zhou, Zhongwu Guo*, A Convergent Synthesis of 6- OBranched β-Glucan Oligosaccharides, Eur. J. Org. Chem., 2015, (13): 2942-2951, IF=2.882 (4) Guochao Liao#, Zhifang Zhou# (contributed equally), Srinivas Burgula, Jun Liao, Cheng Yuan, Qiuye Wu, Zhongwu Guo*, Synthesis and Immunological Studies of Linear Oligosaccharides of βGlucan As Antigens for Antifungal Vaccine Development, Bioconjugate Chem., 2015, 26(3): 466-476 IF=4.485 (3) Zhifang Zhou, Guochao Liao, Sergejs Stepanovs, Zhongwu Guo*, Quantifying the Efficiency of NPhenyl-D-mannosamine to Metabolically Engineer Sialic Acid on Cancer Cell Surface, Journal of Carohydrate Chemistry, 2014, 33(7-8): 395-407 (2) Zhifang Zhou# (contributed equally), Mohabul Mondal#, Guochao Liao#, Zhongwu Guo*, Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers, Org. Biomol. Chem., 2014, 12(20): 3238-3245, IF=3.423 (1) Qianli Wang, Zhifang Zhou, Shouchu Tang, Zhongwu Guo*, Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse, ACS Chem. Bio., 2012, 7(1): 235-240, IF=4.592

（1）Novel Synthetic Anticancer, Antifungal, and Antibacterial Vaccines, 24 March 2016, PCT, WO 2016/044164 A1 （2）募集抗体并靶向肿瘤细胞的双功能分子， 2017年12月29日，国际专利PCT, 申请号： PCT/CN2017/119779 （3）一种利用纤维素固定化CBD-EndoS融合酶的方法，中国发明专利，申请号：201810358946.3 （4）带有羟氨基的艾塞那肽类似物及其应用，中国发明专利，申请号：201810613152.7 （5）一种高效表达糖苷内切酶Endo S或其突变体的方法，中国发明专利，申请号： 201810900866.6