学习工作经历（自本科填起） 2003-2007 合肥工业大学，生物工程专业，工科学士； 2007-2010 四川大学，发酵工程专业，工科硕士； 2010-2014 江南大学，发酵工程专业，工科博士。

主持项目 1.国家自然科学基金青年基金，31871738，研究期限：2019.1-2022.12； 2. 国家 自然科学基金青年基金， 31401634，研究期限： 2015.1-2017.12 （已完成）； 2. 江苏省自然科学基金-青年基金， BK20140135，研究期限： 2014.7-2017.6（已完成）； 3. 中国博士后基金第62批面上基金， 2017M621631，研究期限： 2017.11-2019.8

1. Rui-Zhi Han, Guo-Chao Xu, Jin-Jun Dong, Ye Ni*. Arginine deiminase: recent advances in discovery, crystal structure and protein engineering for improved properties as an anti-tumor drug. Applied Microbiology & Biotechnology (2016) 100: 4747-4760 2. Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Recent advances in discovery, heterologous expression, and molecular engineering of cyclodextrin glycosyltransferase for versatile applications. Biotechnology Advances, 32, 415-428. 3. Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Fusion of self-assembling amphipathic oligopeptides with cyclodextrin glycosyltransferase improves 2-O-D-glucopyranosyl-l-ascorbic acid synthesis with soluble starch as the glycosyl donor. Applied and Environmental Microbiology, 80, 4717-4724. 4. Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Iterative saturation mutagenesis of -6 subsite residues in cyclodextrin glycosyltransferase from Paenibacillus macerans to improve maltodextrin specificity for 2-Od-glucopyranosyl-l-ascorbic acid synthesis. Applied and Environmental Microbiology, 79, 7562-7568. 5. Han, R.Z., Li, J.H., Shin, H.D. et al. (2013) Carbohydrate-binding module-cyclodextrin glycosyltransferase fusion enables efficient synthesis of 2-O-d-glucopyranosyl-l-ascorbic acid with soluble starch as the glycosyl donor. Applied and Environmental Microbiology, 79, 3234-3240. 6. Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Systems engineering of tyrosine 195, tyrosine 260, and glutamine 265 in cyclodextrin glycosyltransferase from Paenibacillus macerans to enhance maltodextrin specificity for 2-O-(D)-glucopyranosyl-(L)-ascorbic acid synthesis. Applied and Environmental Microbiology, 79, 672-677. 7. Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Site-saturation engineering of lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans to enhance substrate specificity towards maltodextrin for enzymatic synthesis of 2-O-D-glucopyranosyl-L-ascorbic acid (AA-2G). Applied Microbiology and Biotechnology, 97, 5851-5860. 8. Han, R.Z., Liu, L., Li, J.H. et al. (2012) Functions, applications and production of 2-O-Dglucopyranosyl-L-ascorbic acid. Applied Microbiology and Biotechnology, 95, 313-320.

1. 一种利用环糊精葡萄糖基转移酶转糖基反应提高染料木素水溶性的方法 申请号： 201710014828.6 韩瑞枝，倪晔，姜明杨，葛彬彬，许国超，董晋军 申请日：2017.1.9 2. 一种利用环糊精葡萄糖基转移酶高产染料木素糖基化衍生物的方法 201710014956.0 韩瑞枝，倪晔，姜明杨，葛彬彬，许国超，董晋军 申请日：2017.1.9 授权专利： 1. 一种可溶性淀粉底物特异性提高的环糊精糖基转移酶，专利授权号： ZL201310542063.5 陈坚，堵国成，刘龙，李江华，韩瑞枝 授权日：2015.5.13 2. 一种麦芽糖底物特异性提高的环糊精糖基转移酶及其制备方法，专利授权号： ZL201210527870.5 陈坚，堵国成，刘龙，李江华，韩瑞枝 授权日：2015.5.13