20XX-20XX 江南大学，生物工程专业，工科学士 2002.9 – 2006.6 南京农业大学食品科技学院 本科 2006.9 – 2011.6 江南大学生物工程学院 硕博连读 2012.1–2012.2日本产业综合研究所(AIST) 访问学者 2013.11–2014.2 日本产业综合研究所(AIST) 访问学者 2016.8 – 2017.8 美国康奈尔大学 访问学者

2011.8-2015.10 江南大学生物工程学院 校聘副教授

主要在研项目： 1. 国家自然基金青年项目“超糖基化缺陷型酿酒酵母生产人源化糖蛋白N-聚糖位点占 有率定向调控” (21406087), 主持 2. 江南大学自主科研计划项目基金“重组酿酒酵母产人促红细胞生成素糖基化机制的 研究”， (JUSRP211A25), 主持 3. 工业生物技术教育部重点实验室开放课题“Alg1结构与膜结合性质的研究”(KLIBKF201106), 主持 教学：代谢工程、发酵工程原理与技术 研究生招生专业： 发酵工程，生物化学与分子生物学

1. Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou*, Guiyang Shi*. Production of L-tyrosine using tyrosine phenol-lyase by whole cell biotransformation approach. Enzyme Microb. Tech. 2019, 131, 109430 2. Yongkun Lv, Sha Xu, Yunbin Lyu, Shenghu Zhou, Guocheng Du, Jian Chen, Jingwen Zhou*. Engineering enzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. Green Chem. 2019, 21(7):1660-1667. 3. Wang Panpan, Zeng Weizhu, Xu Sha, Du Guocheng, Zhou Jingwen*, Chen Jian*. Current challenges facing one-step production of l-ascorbic acid. Biotechnol Adv. 2018, 36(7): 1882-1899. 4. Huijie Zhang, Ting Yan, Sha Xu, Shini Feng, Dandi Huang, Morihisa Fujita, Xiaodong Gao*. Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides. Mater Sci Eng C Mater Biol Appl. 2017, 73:144-151. 5. Weizhu Zeng, Hailin Zhang, Sha Xu, Fang Fang, Jingwen Zhou*. Biosynthesis of keto acids by fedbatch culture of Yarrowia lipolytica WSH-Z06. Bioresour Technol. 2017, 243:1037-1043. 6. Sha Xu, Geyuan Zhang, Huijie Zhang, Toshihiko Kitajima, Hideki Nakanishi, Xiaodong Gao*. Effects of Rho1, a small GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae. Microb Cell Fact. 2016, 15 (1):179. 7. Shengtao Li, Ning Wang, Sha Xu, Jian Yin, Hideki Nakanishi, Neta Dean, Xiaodong Gao*. Quantitative study of yeast Alg1 beta-1,4 mannosyltransferase activity, a key enzyme involved in protein N-glycosylation. Biochim Biophys Acta 1861. 2016 (1 Pt A):2934-2941. 8. Yu Deng, Mingxue Sun, Sha Xu, Jingwen Zhou*. Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae. J Appl Microbiol. 2016, doi:10.1111/jam.13105. 9. Jingwen Zhou*, Kui Wang, Sha Xu, Junjun Wu, Peiran Liu, Guocheng Du, Jianghua Li*, Jian Chen. Identification of membrane proteins associated with phenylpropanoids tolerance and transport in Escherichia coli BL21. J Proteomics. 2015, 113: 15-28.10. Sha Xu, Xiaobei Wang, Guocheng Du, Jingwen Zhou*, Jian Chen. Enhanced production of Lsorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003. Microb Cell Fact. 2014, 13:146.11. Sha Xu, Yaqiong Guo, Guocheng Du, Jingwen Zhou*, Jian Chen. Self-cloning significantly enhances the production of catalase in Bacillus subtilis WSHDZ-01. Appl Biochem Biotechnol. 2014, 173(8): 2152-62. 12. Sha Xu, Zhengxiong Zhou, Zhaozhe Hua, Guocheng Du, Jingwen Zhou*, Jian Chen. Efficient transformation of Rhizopus delemar by electroporation of germinated spores. J Microbiol Meth. 2014. 103: 58-63. 13. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen* Arginine: a novel compatible solute to protect Candida glabrata against hyperosmotic stress. Proc Biochem. 2011, 44(6): 1230-1235. 14. Yi Qin, Liming Liu, Changhao Li, Sha Xu, and Jian Chen*. Accelerating glycolytic flux of Torulopsis glabrata CCTCC M202019 at high oxiodreduction potential created using potassium ferricyanide. Biotechnol Prog, 2010, 26(6): 1551-1557. 15. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Water-forming NADH oxidase protects Torulopsis glabrata against hyperosmotic stress. Yeast. 2010, 27(4): 207-216. 16. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Proline enhances Torulopsis glabrata growth during hyperosmotic stress. Biotechnol Bioproc Eng. 2010, 15(2): 285-292. 17. 董宁远, 张阁元, 徐沙, 高晓冬*. 来源于胞曲霉的α-1,2-甘露糖苷酶在酿酒酵母Δalg3Δoch1Δ mnn1菌株中的定位表达. 食品与发酵工业. 2016, 42 (6):1-6. 18. 张阁元, 徐沙, 高晓冬*, 中西秀树. 酿酒酵母糖基化缺陷型菌株中ALG6基因的过量表达. 食品 与发酵工业. 2015, 41 (5):1-7. 19. 贺铁凡, 徐沙, 张阁元, 中西秀树, 高晓冬*. 重构酿酒酵母N-糖基化途径生产人源化糖蛋白. 微 生物学报. 2014, 54 (5):509-516. 20. 徐沙, 中西秀树, 高晓冬*. 糖蛋白药物表达系统糖基化研究进展. 微生物学报. 2013, 53 (3):221229

1. 堵国成, 徐沙, 刘立明, 陈坚. 一种添加脯氨酸促进丙酮酸过量积累的方法. 公开号： 101225410. 2. 陈坚, 徐沙, 刘立明, 堵国成. 一种提高光滑球拟酵母抵御高渗透压胁迫的方法. 公开 号：101591670