1999.9-2003.7 江南大学，生物工程专业，工科学士 2007.9-2012.3 江南大学，发酵工程专业，工科博士

2003.9-2005.7 江南大学 生物工程学院 辅导员 2012.5-2015.9 江南大学 生物工程学院 校聘副教授 2015.10至今 江南大学 生物工程学院 副教授

1、主持国家自然科学基金 (极高细胞密度下乙醇历史积累抑制毕赤酵母表达外源蛋白的分子机制 及解抑制策略研究No. 31301408)，2014.1-2016.12； 2、主持江苏省自然科学基金 (乙醇历史积累抑制毕赤酵母表达蛋白的机制及解抑制策略No. BK20130122)，2013.7-2016.6； 3、主持中国博士后科学基金（诱导前比生长速率影响毕赤酵母诱导启动效率的机制研究No. 2014M551501），2014.6-2015.12； 4、主持江南大学自主科研计划-重点项目（高粘度、高密度发酵过程关键技术与装备 JUSRP51632A），2016.1-2018.12； 5、主持江苏省政策引导类计划（产学研合作）--前瞻性联合研究项目（毕赤酵母高效吸附稀贵金 属离子关键技术研发及产业化 BY2016022-15），2016.7-2018.6。

1. Jian Ding, Lu-qiang Jia, Enock Mpofu, Min-Jie Gao*, Xi-dong Ren*. An On-line Adaptive Glucose Feeding System Incorporating Patterns Recognition for Glucose Concentration Control in Glutamate Fermentations，Biotechnology and Bioprocess Engineering，2016, 21(6): 758-766 2. Min-Jie Gao, Xiao-Bei Zhan, Peng Gao, Xu Zhang, Shi-Juan Dong, Zhen Li, Zhong-Ping Shi, Chi-Chung Lin. Improving performance and operational stability of porcine interferon-α production by Pichia pastoris with combinational induction strategy of low temperature and methanol/sorbitol co-feeding. Applied Biochemistry and Biotechnology, 2015, 176(2): 493-504. 3. Min-Jie Gao, Cheng Wang, Zhi-Yong Zheng, Li Zhu, Xiao-Bei Zhan, Chi-Chung Lin. Improving arachidonic acid fermentation by Mortierella alpina through multi-Stage temperature and aeration rate control in bioreactor. Preparative Biochemistry and Biotechnology, 2016, 46(4):360-367. 4. Min-Jie Gao, Zhong-Ping Shi. Process control and optimization for heterologous protein productions by methylotrophic Pichia pastoris. Chinese Journal of Chemical Engineering, 2013, 21(2): 216-226. 5. Min-Jie Gao, Xiao-Bei Zhan, Zhi-Yong Zheng, Jian-Rong Wu, Shi-Juan Dong, Zhen Li, Zhong-Ping Shi, Chi-Chung Lin. Enhancing pIFN-α production and process stability in fed-batch culture of Pichia pastoris by controlling the methanol concentration and monitoring the responses of OUR/DO levels. Applied Biochemistry and Biotechnology, 2013, 171: 1262-1275. 6. Min-Jie Gao, Zhen Li, Rui-Song Yu, Jian-Rong Wu, Zhi-Yong Zheng, Zhong-Ping Shi, Xiao-Bei Zhan, Chi-Chung Lin. Methanol/sorbitol co-feeding induction enhanced porcine interferon-α production by P. pastoris associated with energy metabolism shift. Bioprocess and Biosystems Engineering, 2012, 35(7): 1125-1136. 7. Min-Jie Gao, Zhi-Yong Zheng, Jian-Rong Wu, Shi-Juan Dong, Zhen Li, Hu Jin, Xiao-Bei Zhan, ChiChung Lin. Improvement of specific growth rate of Pichia pastoris for effective porcine interferon-α production with an on-line model based glycerol feeding strategy. Applied Microbiology and Biotechnology, 2012, 93(4): 1437-1445. 8. Min-Jie Gao, Shi-Juan Dong, Rui-Song Yu, Jian-Rong Wu, Zhi-Yong Zheng, Zhong-Ping Shi, XiaoBei Zhan. Improvement of ATP regeneration efficiency and operation stability in porcine interferon-α production by Pichia pastoris under lower induction temperature. Korean Journal of Chemical Engineering, 2011, 28(6): 1412-1419. 9. Ying Liang, Li Zhu; Minjie Gao; Zhiyong Zheng; Jianrong Wu; Xiaobei Zhan. Influence of Tween-80 on the production and structure of water-insoluble curdlan from Agrobacterium sp. International journal of biological macromolecules, 2018, 106:611-619. 10. Jian-Rong Wu, Jing-bo Zhang, Pan-pan Wang, Li Zhu, Min-Jie Gao, Zhi-Yong Zheng, Xiao-Bei Zhan. Production of rhamnolipids by semi-solid-state fermentation with Pseudomonas aeruginosa RG18 for heavy metal desorption. Bioprocess and Biosystems Engineering, 2017, 157:521-526. 11. Ying Liang, Li Zhu, Han Ding, Min-Jie Gao, Zhi-Yong Zheng, Jian-Rong Wu, Xiao-Bei Zhan. Enhanced production of curdlan by coupled fermentation system of Agrobacterium sp. ATCC 31749 and Trichoderma harzianum GIM 3.442. Carbohydrate Polymers, 2017, 157: 1687-1694. 12. Jian Ding, Min-Jie Gao, Guo-Li Hou, Ke-Xue Liang. Effect of ethanol accumulation on porcine interferon-α production by Pichia pastoris and activities of key enzymes in carbon metabolism. Applied Biochemistry and Biotechnology, 2015, 176:1964-1974. 13. Jian Ding, Min-jie Gao, Guo-li Hou, Ke-xue Liang, Rui-song Yu, Zhen Li, Zhong-ping Shi. Stabilizing porcine interferon-α production by Pichia pastoris with an ethanol on-line measurement based DO-Stat glycerol feeding strategy. Journal of Chemical Technology & Biotechnology, 2014, 89(12): 1948-1953. 14. Jian Ding, Chun-ling Zhang, Min-jie Gao, Guo-li Hou, Ke-xue Liang, Chun-hua Li, Jian-ping Ni, Zhen Li, Zhong-ping Shi. Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding induction strategy. Journal of Biotechnology, 2014, 177: 35-44. 15. Li-Bo Yang, Xiao-Bei Zhan, Zhi-Yong Zheng, Jian-Rong Wu, Min-Jie Gao, Chi-Chung Lin. A novel osmotic pressure control fed-batch fermentation strategy for improvement of erythritol production by Yarrowia lipolytica from glycerol. Bioresource Technology, 2014, 151: 120-127. 16. Rui-Song Yu, Shi-Juan Dong, Yu-Min Zhu, Hu Jin, Min-Jie Gao, Zuo-Ying Duan, Zhi-Yong Zheng, Zhong-Ping Shi, Zhen Li. Effective and stable porcine interferon-α production by Pichia pastoris fedbatch cultivation with multi-variables clustering and analysis. Bioprocess and Biosystems Engineering, 2010, 33: 473-483. 17. Hu Jin, Zhi-Yong Zheng, Min-Jie Gao, Zuo-Ying Duan, Zhong-Ping Shi, Zheng-Xiang Wang, Jian Jin. Effective induction of phytase in Pichia pastoris fed-batch culture using an ANN pattern recognition model based on-line adaptive control strategy. Biochemical Engineering Journal, 2007, 37: 26-33. 18. 高鹏，丁健，张许，赵玥，张猛，高敏杰*，吴剑荣*，詹晓北. 乙醇胁迫抑制毕赤酵母表达外 源蛋白的转录组学分析. 生物工程学报. 2016, 32(6): 1-15. 19. 孙东东, 郑志永, 李晶, 詹晓北, 高敏杰, 金亚楠. 基于CFD模拟的新型径向流搅拌桨设计. 过程工 程学报, 2017,17: 677-683 20. 汪汇慧, 金虎, 高敏杰, 戴科科, 董世娟, 于瑞嵩, 李震, 史仲平. 甲醇/山梨醇共混流加诱导改变代 谢产能途径强化毕赤酵母生产猪α干扰素的发酵性能. 生物工程学报, 2012, 28(2): 164-177. 21. 刘国强, 金虎, 高敏杰, 戴科科, 汪汇慧, 李震, 史仲平. 降低诱导温度对改善猪α-干扰素发酵生产 性能和ATP再生效率的作用. 化工学报, 2011, 62 (2): 444-451. (EI) 22. 金虎, 高敏杰, 徐俊, 段作营, 刘立明, 李震, 史仲平. 多变量在线测量条件下的猪α-干扰素高效表 达. 过程工程学报, 2009, 9 (3): 563-567.

1. 詹晓北, 郑志永, 高敏杰, 丁春华. 一种应用于发酵罐的错流导向式搅拌桨. 专利号： CN201310577861.1 2. 詹晓北， 朱莉， 向荣华， 郑志永， 吴剑荣， 高敏杰，张洪涛. 一种瓶载真姬菇的方法. 专利号：CN201310564418.0 3. 高敏杰，詹晓北，史仲平，丁健，杨帅. 一种重组毕赤酵母表达外源蛋白过程的专家控制系 统. 专利号: CN201410767928.2 4. 高敏杰，詹晓北，史仲平，丁健，蒋芸，潘晴. 一种提高大肠杆菌聚唾液酸产量的专家控制系 统. 专利号: CN201410815552.8 5. 郑志永，孙东东，詹晓北，高敏杰.一种装配扇环型凹面叶片的气液分散搅拌器装置. 专利 号： CN201610269169.6 6. 郑志永，孙东东，詹晓北，章文劼，章金元，高敏杰.一种搅拌装置和含有搅拌装置的反应器. 专利号：CN201620842543.2 7. 章金元，孙东东，郑志永，詹晓北，高敏杰. 一种搅拌式反应器装置. 专利号： CN201621210019.X 8. 董新颖，郑志永，李成伍，金亚楠，高敏杰. 一种取样装置及含有该取样装置的反应容器. 专 利号：CN201621188082.8 9. 郑志永，王子凡，詹晓北，高敏杰. 一种高效传质、传热的大规模气液和气液固反应器装置. 专利号：CN201610496423.6 10. 郑志永，王子凡，詹晓北，高敏杰. 一种反应器装置. 专利号：CN201620668461 11. 高敏杰，洪瀚，詹晓北，李志涛，沈宇峰，郑志永. 一种利用氯化钙处理毕赤酵母吸附废水 中铑离子的方法. 专利申请号：201611025072.7 12. 高敏杰，洪瀚，詹晓北，李志涛，沈宇峰，郑志永. 一种利用盐酸处理毕赤酵母吸附废水中 铑离子的方法. 专利申请号：201611025002.1 13. 詹晓北，李志涛，高敏杰，赵玥，王支海，李菲菲，王上. 一种海鲜菇菌糠发酵饲料及其加 工方法. 专利申请号：201611157288.9 14. 詹晓北，李志涛，高敏杰，赵玥，王支海，李菲菲，王上. 一种灵芝糠发酵饲料及其加工方 法. 专利申请号：201611157287.4 15. 郑志永 陈瑜琦 詹晓北 高敏杰 刘和. 装配折流筛板的气升式反应器. 专利申请号： 201710207598.5 16. 詹晓北、王支海、高敏杰、朱莉. 一种抗菌凝胶及其制备方法. 专利申请号： 201710425613.3 17. 詹晓北、李志涛、高敏杰、郑志永、朱莉. 一种菌糠发酵饲料发酵罐设备及其应用. 专利申 请号：201710432181.9 18. 吴剑荣，詹晓北，高敏杰，张洪涛，蒋芸. 一种双聚唾液酸仿生材料的制备方法. 专利申请 号：201711089255.X 19. Zhiyong Zheng, Yuqi Chen, Xiaobei Zhan, Minjie Gao. Airlift Reactor Assembly with Helical Sieve Plate. USP 15,795,320 20. Zhiyong Zheng, Sun Dongdong, Xiaobei Zhan, Minjie Gao. Gas-liquid dispersion mixing device equipped with annular sector-shaped concave surface impeller blade. USP 15,548,080