2004-2009 上海交通大学大学，生物医学工程（生物工程）专业，工科博士 2000-2004 上海交通大学大学，生物技术专业，理科学士 其中，2014/10-2015/10，美国明尼苏达大学，生物技术中心，访问学者

2020-至今 江南大学，粮食发酵工艺与技术国家工程实验室，副教授 2009-2020 江南大学，生物工程学院，副教授

1. 强化实验教学效果的人才培养模式探索 校级教改项目 2011年 排名第4 2. 综合性、研究型微生物育种实践教学探索 校级教改项目 2011年 排名第3 3. 《生物技术基础》双语精品课程“三元一体”建设 校级教改项目 2015年 排名第3 4. 生物技术概论-Essentials of Biotechnology 江苏高校省级英语授课精品课程 2014年 排 名第3

. Guangming Fan, Yu Gu, Jiaojiao Zhang, Yu Xin*, Jun Shao*, Francesca Giampieri, Maurizio Battino*, Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy. International Journal of Molecular Sciences, 2019, 20, 6313. (IF 4.183) 2. Jun Shao, Yunbin Zhang, Guangming Fan, Yu Xin*, Yong Yao*, Transcriptome analysis identified a novel 3LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy. BMC Medical Genomics, 2019, 12: 134. (IF 2.568) 3. Jun Shao, Guangming Fan, Xiaowen Yin, Yu Gu, Xiaolu Wang, Yu Xin*, Yong Yao*, A novel transthyretin/STAT4/miR-223-3p/FBXW7 signaling pathway affects neovascularization in diabetic retinopathy. Molecular and Cellular Endocrinology, 2019, 498，110541. (IF 3.693) 4. Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao*, Yu Xin*, Chao Sun*, KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. Journal of Cellular Physiology, 2019, 234, 17269-17279 (IF 4.522). 5. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Liang Zhang*，Soluble expression of Thermomicrobium roseum sarcosine oxidase and characterization of N-demethylation activity. Molecular Catalysis, 2019, 464, 48-56 (IF 4.211). 6. Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*，Preparation and characterization of copper-Brevibacterium cholesterol oxidase hybrid nanoflowers, International Journal of Biological Macromolecules, 2019, 126, 539-548 (IF 4.784). 7. Mengling Zheng, Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*, Preparation, reconstruction, and characterization of a predicted Thermomicrobium roseum sarcosine oxidase. Molecular Catalysis, 2018, 455, 132-142 (IF 4.211). 8. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Mengling Zheng, Liang Zhang*, Affinity adsorption of bovine hyaluronidase with ligands targeting to active site. Journal of Chromatography B, 2018, 1092,422-431 (IF 2.813). 9. Jun Shao, Ying Yin, Xiaowen Yina, Li Jia, Yu Xin*, Jian Zouc*, Yong Yao*, Transthyretin exerts pro-apoptotic effects in human retinal microvascular endothelial cells through a GRP78dependent pathway in diabetic retinopathy. Cellular Physiology and Biochemistry， 2017, 43, 788-800. (IF 5.50) 10. Yu Xin，Mengling Zheng，Qing Wang，Liushen Lu，Ling Zhang，Yanjun Tong，Wu Wang，Structural and catalytic alteration of sarcosine oxidase through reconstruction with coenzyme-like ligands，Journal of Molecular Catalysis B: Enzymatic，2016，133: S250–S258. (IF 2.269) 11. Yu Xin，Liushen Lu，Qing Wang，Ling Zhang，Yanjun Tong，Wu Wang，Coenzyme-like ligands for affinity isolation of cholesterol oxidase, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences，2016, 1021, 169-174. (IF 2.813) 12. Xin Y., Liu L.H., Chen B.Z., Zhang L., Tong Y.J., Affinity purification of aprotinin from bovine lung. Journal of Separation Science, 2015, 38, 1441-1448. (IF 2.516) 13. Xin Y., Yang H.L., Xia X.L., Zhang L., Cheng C., Mou G.C., Shi J.B., Han Y.F., Wang W., Affinity purification of a cholesterol oxidase expressed in Escherichia coli. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2011, 879, 853-858. (IF 2.813) 14. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Wang W., Preparation and characterization of affinity sorbents based on isoalloxazine-like ligands for separation of flavoenzymes. Journal of Separation Science, 2011, 34, 2940-2949. (IF 2.516) 15. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Cheng C., Wang W., Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp.. Process Biochemistry, 2012, 47, 1539-1544. (IF 2.883) 16. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Chen Y., Wang W., Expression and comparison of recombinant cholesterol oxidases (COD) in Escherichia coli with native cholesterol oxidase expressed in Brevibacterium sp.. Afr J Biotechnol, 2011, 10(66), 14968-14976. 17. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Chen Y., Wang W., Affinity purification of urinary trypsin inhibitor from human urine. Journal of Separation Science, 2012, 35, 1–6. (IF 2.516) 18. Tong Y.J., Xin Y., Yang H.L., Zhang L., Zhang Y.R., Chen Y., Xia X.L., Wang W., Preparation and Performance Research on Glutathione Molecularly Imprinted Polymers. Chromatographia, 2011, 74, 443–450. (IF 1.552) 19. Xin Y., Tong Y.J., Yang H.L., Zhang L., Zhang Y.R., Chen Y., Wang W., Study on the Glutathione Molecularly Imprinted Polymers with different functional monomers. Acta Chimica Sinica, 2012, 70 (6), 803-811. (IF 2.463) 20. Shao J., Xin Y., Li R.X., Fan Y., Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies. Clinical Biochemistry, 2011 44, 681-685. (并列第一) (IF 2.43) 21. Shao J., Xin Y., Yao Y., Correlation of misfolded transthyretin in abnormal vitreous and high myopia related ocular pathologies. Clinica Chimica Acta, 2011, 412, 2117-2121. (并列第一)(IF 2.735) 22. Xin Y., Dong D.X., Wang T., Li R.X., Affinity purification of serine proteinase from Deinagkistrodon acutus venom. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2007, 859 (1), 111-118. (IF 2.813) 23. Xin Y., Dong D.X., Chen D.Z., Li R.X., Structural and biological characterization of a novel acutobinlike enzyme isolated from the venom of the sharp-nosed pit viper (Deinagkistrodon acutus). Biotechnology and Applied Biochemistry, 2009, 53, 123-131. (IF 1.559) 24. Shao J., Xin Y., Yao Y., Zhu J., Functional analysis of misfolded transthyretin extracted from abnormal vitreous with high myopia related ocular pathologies. Clinica Chimica Acta, 2012, 415, 20-24 . (并列第一) (IF 2.735) 25. Yanjun Tong, Yu Xin, Hailin Yang, Ling Zhang, Xiumei Tao, Hui Xu, Wu Wang, Novel affinity purification of monomeric sarcosine oxidase expressed in Escherichia coli. Journal of Separation Science, 2013, 36, 3086–3092. (IF 2.516) 26. Yuran Zhang, Yu Xin, Hailin Yang, Ling Zhang, Xiaole Xia, Yanjun Tong, Yi Chen, Wu Wang, Thermal inactivation of xanthine oxidase from Arthrobacter M3: mechanism and the corresponding thermostabilization strategy. Bioprocess and Biosystems Engineering, 2014, 37 (4): 719-725 (IF 2.371). 27. Yi Chen,Yu Xin, Hailin Yang, Ling Zhang, Yuran Zhang, Xiaole Xia, Yanjun Tong, Wu Wang, Immobilization and stabilization of cholesterol oxidase on modified sepharose particles. International Journal of Biological Macromolecules, 2013, 56, 6-13. (IF 4.784)

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