1999-2003 华中农业大学，食品科学与工程专业，工学学士 2003-2006 华中农业大学，微生物学专业，理学硕士 2006-2009 江南大学，生物工程专业，工学博士

2009-至今 江南大学，留校任教

[1] 合成生物技术与生物系统工程，国家自然科学基金优秀青年基金项目(21822806，研究 经费130万元). 2019年1月1日-2021年12月31日. 项目主持人； [2] 酿酒酵母血红素合成途径胞质重构强化黄酮羟化酶功能，国家自然科学基金面上项目 (31670095，研究经费67万元). 2017年1月1日-2020年12月31日. 项目主持人； [3] 水飞蓟宾合成氧化还原酶体系构建与优化. 江苏省六大人才高峰计划项目(2015-JY005，研究经费6万元). 2016年1月-2018年12月，项目主持人； [4] 维生素C从头合成关键模块功能解析与调控，高等学校全国优秀博士学位论文作者专项 资金(201256, 研究经费50万元)，2012年1月-2016年12月. 项目主持人； [5] 解脂亚洛酵母酮酸转运蛋白的生理功能与调控机制. 国家自然科学基金面上项目 (21276109，研究经费78万元). 2013年1月1日-2016年12月31日. 项目主持人； [6] 生化网络重构与维生素生产新菌种. 863项目(2012AA022103，研究经费1024万元). 2012 年11月1日-2015年12月31日. 课题负责人； [7] 维生素C合成过程吡咯喹啉醌代谢关键基因及其调控机制. 教育部新世纪优秀人才支持 计划(NCET-12-0876，研究经费50万元), 2012年1月-2015年12月. 项目主持人； [8] 代谢工程改造酿酒酵母合成D-柠檬烯的关键问题研究. 国家自然科学基金青年科学基金 项目 (31000807，研究经费20万元). 2011年1月1日-2013年12月1日. 项目主持人。

[1] Guoqiang Zhang, Xinrui Zhao, Xueliang Li, Guocheng Du, Jingwen Zhou*, Jian Chen*. Challenges and possibilities for bio-manufacturing cultured meat. Trends in Food Science & Technology, 2020. 97: 443-450. [2] Weizhu Zeng, Likun Guo, Sha Xu, Jian Chen, Jingwen Zhou*. High-Throughput Screening Technology in Industrial Biotechnology. Trends in Biotechnology, 2020. [3] Qingzi Lei, Weizhu Zeng, Jingwen Zhou*, Guocheng Du*. Efficient separation of αketoglutarate from Yarrowia lipolytica WSH-Z06 culture broth by converting pyruvate to Ltyrosine. Bioresource Technology. 2019. Accepted. [4] Yongkun Lv, Sha Xu, Yunbin Lyu, Shenghu Zhou, Guocheng Du, Jian Chen, Jingwen Zhou*. Engineering enzymatic cascades for efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. Green Chemistry. 2019, 21, 1660-1667 [5] Shenghu Zhou, Yunbin Lyu, Huazhong Li, Mattheos A.G. Koffas, Jingwen Zhou*. Finetuning the (2S)-naringenin synthetic pathway using an iterative high-throughput balancing strategy. Biotechnology and Bioengineering. 2019, 116(6): 1392-1404. [6] Yunbin Lyu, Weizhu Zeng, Guocheng Du, Jian Chen, Jingwen Zhou*. Efficient bioconversion of epimedin C to icariin by a glycosidase from Aspergillus nidulans. Bioresource Technology, 2019. 289: 121612. [7] Zhengshan Luo, Weizhu Zeng, Guocheng Du, Jian Chen, Jingwen Zhou*. Enhanced Pyruvate Production in Candida glabrata by Engineering ATP Futile Cycle System. ACS Synthetic Biology, 2019. 8(4): 787-795. [8] Panpan Wang, Weizhu Zeng, Sha Xu, Guocheng Du, Jingwen Zhou*, Jian Chen*. Current challenges facing one-step production of L-ascorbic acid. Biotechnology Advances. 2018, 36, 1882-1899. [9] Yongkun Lv, Xiaozhong Cheng, Di Wu, Guocheng Du, Jingwen Zhou*, Jian Chen*. Improving bioconversion of eugenol to coniferyl alcohol by in situ eliminating harmful H2O2. Bioresource Technology, 2018. 267: 578-583. [10] Weiping Zhang, Yan Cheng, Yudong Li, Guocheng Du, Guangfa Xie, Huijun Zou, Jingwen Zhou*, Jian Chen*. Adaptive evolution relieves nitrogen catabolite repression and decreases urea accumulation in cultures of the Chinese rice wine yeast strain Saccharomyces cerevisiae XZ-11. Journal of Agricultural and Food Chemistry, 2018, 66(34):9061-9069. [11] Mei Zhao, Dixuan Huang, Xiaojuan Zhang, Mattheos A.G. Koffas, Jingwen Zhou*, Yu Deng*. Metabolic engineering of Escherichia coli for producing adipic acid through the reverse adipate-degradation pathway. Metabolic Engineering, 2018, 47:254-262. [12] Weiping Zhang, Yudong Li, Yiwang Chen, Sha Xu, Guocheng Du, Huidong Shi, Jingwen Zhou*, Jian Chen*. Complete genome sequence and analysis of the industrial Saccharomyces cerevisiae strain N85 used in Chinese rice wine production. DNA Research, 2018. 25(3): 297306. [13] Weiping Zhang, Guocheng Du, Jingwen Zhou*, Jian Chen*. Regulation of Sensing, transportation, and catabolism of nitrogen sources in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews, 2018, 82(1). e00040-17. [14] Zhengshan Luo, Song Liu, Guocheng Du, Sha Xu, Jingwen Zhou*, Jian Chen*. Enhanced pyruvate production in Candida glabrata by carrier engineering. Biotechnology and Bioengineering, 2018, 115 (2): 473-482.[15] Yongkun Lv, Song Gao, Sha Xu, Guocheng Du, Jingwen Zhou*, Jian Chen*. Spatial organization of silybin biosynthesis in milk thistle [Silybum marianum (L.) Gaertn]. The Plant Journal, 2017. 92(6): 995-1004. [16] Weizhu Zeng, Hailin Zhang, Sha Xu, Fang Fang, Jingwen Zhou*. Biosynthesis of keto acids by fed-batch culture of Yarrowia lipolytica WSH-Z06. Bioresource Technology, 2017. 243: 10371043. [17] Yongkun Lv, Xiaozhong Chen, Guocheng Du, Jingwen Zhou*, Jian Chen*. Engineering of an H2O2 auto-scavenging in vivo cascade for pinoresinol production. Biotechnology and Bioengineering, 2017. 114(9): 2066-2074. [18] Shenghu Zhou, Renpeng Ding, Jian Chen, Guocheng Du, Huazhong Li*, Jingwen Zhou*. Obtaining a panel of cascade promoter-5′-UTR complexes in Escherichia coli. ACS Synthetic Biology, 2017. 6(6): 1065-1075； [19] Zhengshan Luo, Song Liu, Guocheng Du, Jingwen Zhou*, Jian Chen*. Identification of a polysaccharide produced by the pyruvate overproducer Candida glabrata CCTCC M202019. Applied Microbiology and Biotechnology. 2017, 101(11): 4447–4458. [20] Peng Zhang, Guocheng Du, Huijun Zou, Guangfa Xie, Jian Chen J, Zhongping Shi*, Jingwen Zhou*. Mutant Potential Ubiquitination Sites in Dur3p Enhance the urea and ethyl carbamate reduction in a model rice wine system. Journal of Agricultural and Food Chemistry, 2017. 65(8): 1641-1648.

1] Jian Chen, Jingwen Zhou, Hongwei Guo, Guocheng Du. A genetically engineered Yarrowia lipolytica with enhanced extracellular secretion of a-ketoglutarate，US 14/142,897； [2] Jian Chen, Jingwen Zhou, Hongwei Guo, Guocheng Du. A genetically engineered Torulopsis glabrata with enhanced extracellular secretion of pyruvic acid，US 9,447,437； [3] Jian Chen, Jingwen Zhou, Hongwei Guo, Yongkun Lv, Guocheng Du. Method for decreasing pyruvate catabolism and increasing of the accumulation of pyruvate in microbes. US 9,518,275； [4] 陈坚，郭洪伟，周景文，堵国成. 一种胞外丙酮酸产量提高的基因工程菌及其应用. 专 利号：ZL201310722490.1 [5] 周景文，陈坚，胡于东，堵国成. 一组氧化葡萄糖酸杆菌强梯度强度启动子. 专利号： ZL201410184839.5 [6] 周景文，陈坚，王奎，堵国成. 一株高黄酮类化合物耐受性大肠杆菌及其构建方法和应 用. 专利号：ZL201410169642.4 [7] 周景文，陈坚，王奎，堵国成. 一株高黄酮类化合物耐受性大肠杆菌工程菌及其构建方 法和应用. 专利号：ZL201410169822.2 [8] 周景文，陈坚，刘沛然，堵国成. 一种可提高大肠杆菌耐热稳定性的蛋白及其应用. 专 利号：ZL201410090643.X [9] 周景文，陈坚，夏雨，堵国成. 一种氧化葡萄糖酸杆菌无抗性标记基因敲除体系. 专利 号：ZL201410055749.6 [10] 周景文，陈坚，朱赛杰，堵国成. 一种代谢工程改造大肠杆菌产圣草酚的方法. 专利 号：ZL201410076587.4