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吴志猛

领域:生物产业 学校:江南大学职称:教授

长期从事糖化学与药物化学交叉的研究工作,致力于糖及糖缀合物的合成新方法学研究 (包括化学合成和生物合成);复杂天然产物(包括复杂寡糖、糖肽、糖脂及其它糖缀合 物)的合成研究...

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教育背景

1995.7-1999.9: 安徽师范大学,学士 1999.7-2002.9: 延边大学化学系,硕士 2002.9-2005.7: 浙江大学化学系,博士 2005.12-2008.6: 美国Karmanos Cancer Institute 博士后 2008.7-2011.9: 美国韦恩州立大学化学系 博士后

工作经历

2011.10-2013.10: 新西兰皇家科学院工业研究院 Research Scientist 2013.11-至今: 江南大学生物工程学院 教授 博导 (2014年入选江苏省特聘教授)

项目课题经历

;主持包括国家自然科 学基金面上项目、江苏省药物化学特聘教授,江苏省创新团队,江苏省六大人才高峰等 在内的省部级科研项目4项

论文、成果、著作等

1. X. Cheng, T. Zhu, H. Hong, Z. Zhou, Z. Wu*, Sortase A-mediated on-resin peptide cleavage and in situ ligation: an efficient one-pot strategy for the synthesis of functional peptides and proteins, Org. Chem. Front., 2017, 4, 2058-2062. 2. X. Zhao, H. Hong, X, Cheng, S, Liu, T, Deng, Z, Gu, Z. Wu*, One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalyst, Sci. Rep. 2017, 7. 6561, DOI:10.1038/s41598-017-06856-y 3. Z. Wu*, X. Cheng , H. Hong , X. Zhao , Z. Zhou, New potent and selective αvβ3 integrin ligands: macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation, Bioorg. Med. Chem. Lett., 2017, 27, 1911–1913. 4. X. Zhao, H. Hong, Z. Wu*, Efficient extracellular expression of transpeptidase sortase A in Pichia Pastoris, Protein Expr. Puri., 2017, 133, 132-138. 5. New Antibiotic Candidates against Helicobacter pylori., S. Wang, S. Cameron, K. Clinch*, G. Evans, Z. Wu, V.. Schramm*, and P. Tyler*, J. Am. Chem. Soc., 2015, 137, 14275−14280 6. Z. Wu, X. Guo, J. Gao, Z. Guo*. Sortase A-mediated chemoenzymatic synthesis of complex glycosylphosphatidylinositol-anchored protein Chem. Commun., 2013, 49, 11689-11691. 7. Z. Wu, X. Guo, G. Guo, Z. Guo*. Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogues Org. Lett., 2013, 15, 5906-5908. 8. X. Guo, Z. Wu(并列第一), Z. Guo*. New Method for Site-Specific Modification of Liposomes with Proteins Using Sortase A-Mediated Transpeptidation , Bioconjugate Chem., 2012, 23, 650-655. 9. Z. Wu, Z. Guo*. Sortase-Mediated Transpeptidation for Site-Specific Modification of Peptides, Glycopeptides, and Proteins (Review Article) J. Carbohydr. Chem. 2012, 31, 48-66. 10. Z. Wu, X. Guo, Z. Guo*. Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides Chem. Commun., 2011, 47, 9218-9220. 11. Z. Wu, X. Guo, Z. Guo*. Chemoenzymatic Synthesis of GlycosylphosphatidylinositolAnchored Glycopeptide Chem. Comm., 2010, 46, 5773-5774.

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