1984年获清华大学环境工程专业学士学位；1986年、1990年先后获无锡轻工业学 院发酵工程专业硕士、博士学位

2005年至今，担任江南大学校长

近5年来主持或完成国家重点研发计划项目、973项目、国家自然科学基金重点项 目等共10项。其中代表性的科研项目如下： 1) 食品加工与食品安全的互作关系与调控基础研究，国家重点研发计划， 2017YFC1600400，2017.12-2022.12； 2) 食品加工过程安全控制的关键科学问题，973项目，2012CB720800，2012.012016.08 3) 酿酒酵母氮代谢物阻遏效应形成机制及其调控，国家自然科学基金重点项目， 31130043，2012.01-2016.12 4) 大肠杆菌合成黄酮类化合物关键前体丙二酰辅酶A的代谢调控，国家自然科学基 金，31370130，2014.01-2017.12 5) 酿酒酵母积累黄酮类化合物过程中丙二酰辅酶A供给的动态调控,国家自然科学基 金，31770097，2018.01-2021.12

1) Yanfeng Liu, Hannes Link, Long Liu, Guocheng Du, Jian Chen, Uwe Sauer. A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis Nature Communications 2016. 7:11933 (2016 IF=12.124) 2) Peng Jin, Zhen Kang, Panhong Yuan, Guocheng Du, Jian Chen. Production of specificmolecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168 Metabolic Engineering 2016. 35:21-30 (2016 IF=8.142) 3) Junjun Wu, Guocheng Du, Jingwen Zhou, Jian Chen. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy Metabolic Engineering 2013, 16:48-55 (2016 IF=8.142) 4) Liming Liu, Yin Li, Yang Zhu, Guocheng Du, Jian Chen. Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metabolic Engineering 2007. 9:2129 (2016 IF=8.142) 5) Xian Yin, Jianghua Li, Hyun-dong Shin, Guoheng Du, Long Liu, Jian Chen. Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects Biotechnology Advances 2015. 33: 830-841 (2016 IF=10.597) 6) Jingwen Zhou, Guocheng Du, Jian Chen. Novel fermentation processes for manufacturing plant natural products Current Opinion in Biotechnology 2014. 25: 17-23 (2016 IF=9.294) 1）陈坚，周景文，郭洪伟，堵国成，Genetically engineered Yarrowia Lipolytica with enhanced extracellular secretion of α-ketoglutarate , US9328363 2）陈坚，康振，堵国成，金鹏， A method of constructing a recombinant Bacillus subtilis that can produce hyaluronic acids within certain molecular weight ranges, US9771607 3）陈坚，堵国成，康振，金鹏，Novel leech hyaluronidase and its application， US9279111 4）陈坚，周景文，郭洪伟，吕永坤，堵国成，A method for decreasing pyruvate catabolism and increasing the accumulation of pyruvate in microbes, US9279111 5）陈坚，殷晓霞，周景文，堵国成，一种产α-酮戊二酸酵母工程菌及其构建方法，ZL 201010578594.6