博士后，活性物质与免疫调节，瑞典卡罗琳斯卡医学院 博士，免疫药理学，新加坡国立大学 　　学士，生物医学，新加坡国立大学

江南大学食品学院教授、博士生导师

研究项目： 1.“丁酸及产丁酸菌在维持肠道稳态及重症胰腺炎中的作用研究”，国自然科学基金面上项目，主持，2019.01-2022.12，58万 2.“针对胰腺健康的酪酸梭菌研究开发”，江苏省双创计划团队项目，2019.01-2021.12，300万 3.“基于调控活性脂质干预1型糖尿病的新型膳食纤维的开发”，无锡市科技发展资金国际科技研发合作项目，主持，2019.01-2021.12 4.“抗菌肽cathelicidins在维持肠道免疫稳态及1型糖尿病发病中的作用研究”，国家自然科学基金重大研究计划（培育项目），主持，2017.01-2019.12，60万 5.“短链脂肪酸调控胰肠区域免疫稳态及机理研究”,中央高校专项自主科研项目-重点项目（A类），主持，项目号JUSRP51613A ，2016.01-2018.12，100万 6.“肠道丁酸在1型糖尿病免疫炎症中作用及分子机制研究”,国家自然科学基金面上项目，主持，2016.01-2019.12，60万 7.“功能脂肪酸与抗菌肽的健康机理与药食应用研究”,“国家级引进人才”入选者，主持，2015.01-2017.12，300万 8.“抗菌肽的天然诱导剂筛选”，国家高端外国专家项目，中方负责人，2014.01-2015.12 9.“抗菌肽cathelicidins 对beta 细胞功能的免疫调节作用及机理研究”，国家自然科学基金青年项目，主持，2015.01-2017.12，26万 10. “功能活性物质的内源诱导对宿主免疫防御与慢性病防治的影响及相关新型营养产品的开发”，江苏省双创计划人才项目，主持，2015.01-2017.12，50万 11.“新型抗糖尿病胰岛炎症的免疫防御肽内源诱导剂的开发”，江苏省六大人才高峰项目，主持，2015.91-2017.12 12.“膳食脂肪与宿主防御肽在胰腺beta细胞功能和糖尿病预防重的作用与机制研究”，江苏省自然科学基金项目，主持，2014.01-2016.12，20万

代表性文章 　　 1) Sun J, Laetitia Furio, Ramine Mecheri, Anne M. van der Does, Erik Lundeberg, Loredana Saveanu, Yong Chen, Peter van Endert, Birgitta Agerberth, Julien Diana. Pancreatic β-cells express a host defense peptide regulating autoimmune diabetes under the influence of the gut microbiota. Immunity. 2015; 43: 304-317. (IF: 24.1) 2) Bei Y#, Pan LL#, Zhou Q#, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J*, Xiao J*. Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury. BMC Med. 2019. DOI: 10.1186/s12916-019-1268-y. (IF: 9.1) 3) Pan X, Fang X, Wang F, Li H, Niu W, Liang W, Wu C, Li J, Tu X, Pan LL, Sun J*. Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue specific mechanisms. Br J Pharmacol. 2019 Jul 26. doi: 10.1111/bph.14806. (IF: 6.6) 4) Liu H, Pan LL, Lv S, Yang Q, Zhang H, Chen W, Lv Z, Sun J*. Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia. Front Physiol. 2019 Aug 6;10:1015. doi: 10.3389/fphys.2019.01015. 5) Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J*. Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction. Mol Nutr Food Res. 2019 Aug 18:e1900307. doi: 10.1002/mnfr.201900307. 6) Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J*. Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice. Front Immunol. 2019 Jul 30;10:1733. doi: 10.3389/fimmu.2019.01733. eCollection 2019. 7) Pan LL, Niu W, Fang X, Liang W, Li H, Chen W, Zhang H, Bhatia M, Sun J*. Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis. Mol Nutr Food Res. 2019 Apr 29:e1801419. doi: 10.1002/mnfr.201801419. [Epub ahead of print] 8) Sun J*, de Vos P. Editorial: Immunomodulatory Functions of Nutritional Ingredients in Health and Disease. Front Immunol. 2019 Jan 24;10:50. doi: 10.3389/fimmu.2019.00050. eCollection 2019. 9) Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL, Sun J*. A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis. Front Immunol. 2018; 9:2513. (IF: 5.5) 10) Pan LL, Deng Y-Y, Wang R, Wu C, Li J, Niu W, Yang Q, Madhav B, Gudmundsson HG, Agerberth B, Diana J and Sun J*. Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice. Front Immunol. 2018; 9:751. (IF: 5.5) 11) He Y, Wu C, Li J, Li H, Sun Z, Zhang H, de Vos P, Pan LL*, Sun J*. Inulin-Type Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. Front Immunol. 2017; 8:1209. (IF: 5.5) 12) Jia L, Shan K, Pan LL, Feng N, Lv Z, Sun Y, Li J, Wu C, Zhang H, Chen W, Diana J, Sun J*, Chen YQ*. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017; 8:1345. (IF: 5.5) 13) Pan LL, Li J, Shamoon M, Bhatia M, Sun J*. Recent Advances on Nutrition in Treatment of Acute Pancreatitis. Front Immunol. 2017; 8:762. (IF: 5.5) 14) Sun J*, Xu M, Diana J, Ortsäter H, ‎Flodström-Tullberg M, Haeggström Z. J, Agerberth B. The antimicrobial peptide cathelicidin is a positive regulator of pancreatic β-cell function. FASEB J. 2016; 30: 884-894. (IF: 5.6) 15) Muhammad Shamoon, Yongquan Chen, Madhav Bhatia*, Sun J*. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016; 20: 73-87. (IF: 4.9) 16) Chen K, Chen H, M Faas M, J de haan B, Li J, Xiao P, Zhang H, Diana J, de Vos P, Sun J*. Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function and microbiota homeostasis. Mol Nutr Food Res 2017; 61(8) (IF: 5.2) 17) Sun Y, He Y, Wang F, Zhang H, de Vos P, Sun J*. Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis. Mol Nutr Food Res 2017; 61(4)　(IF: 5.2) 18) Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J*. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxid Med Cell Longev 2016; 2016:7864150. (IF: 4.9) 19) Sun J, Dahlén B, Agerberth B, Haeggström ZJ. The host defense peptide LL-37 induces release of eicosanoids and eosinophil cationic protein from human eosinophils – implications for asthma. Allergy. 2013;68:304-311. (IF: 6.0) 20) Sun J, Ramnath RD, Tamizhselvi R, Bhatia M. PKC and PI3K-Akt Pathways are Involved in Substance P-Induced ERK1/2-NF-κB Activation and Chemokine Expression in Mouse Macrophages. FASEB J. 2009;23:997-1010. (IF: 6.401) 21) Sun J, Ramnath RD, Zhi L, Tamizhselvi R, Bhatia M. Substance P Enhances NF-κB Transactivation and Chemokine Response in Murine Macrophages via ERK1/2 and p38 MAPK Signaling Pathways. Am J Physiol Cell Physiol. 2008; 294:C1586-1596. (IF: 4.230)

2014-2016年 中国专利申请5项