教育背景
1996.09 - 2000.06, 华中农业大学,兽医学专业毕业,学士 2000.09 - 2003.06, 华中农业大学,兽医学专业毕业,硕士 2003.09 - 2006.06, 华中农业大学,兽医学专业毕业,博士
工作经历
2006/7-2008/12,华中农业大学,农业微生物学国家重点实验室,博士后 2008/12-2011/8,华中农业大学,动物科技学院-动物医学院,副教授 2011/8-2013/10,英国帝国理工学院,博士后,合作导师:Wendy Barclay 2013/12-至今,华中农业大学,动物科技学院-动物医学院,教授,博士生导师
项目课题经历
论文、成果、著作等
A著作类 1. 参译《Veterinary Pharmacology and Therapeutics,9th》,中国农业出版社,国际最新版通用教材,2011 2. 参编《猪流感》及《关注人兽共患病 关爱人类健康》著作2部。 B论文类 1. Proteomic analysis of chicken embryo fibroblast cells infected with recombinant H5N1 avian influenza viruses with and without NS1 eIF4GI binding domain. Oncotarget, 2017.11. 2. Identification and characterization of a protective antigen, PlpB of bovine Pasteurella multocida strain LZ-PM. Dev Comp Immunol. 2017 Jun;71:1-7. 3. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively. Int J Mol Sci. 2017 Apr 3;18(4). 4. Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Scientific Reports, 2017 Jan 12;7:40698. 5. Molecular cloning and functional analysis of the duck TIR domain-containing adaptor inducing IFN-β (TRIF) gene. Dev Comp Immunol. 2016 Dec;65:369-76. 6. Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells. Sci Rep. 2015 Oct 9;5:14991. 7. Glycosylation on Hemagglutinin Affects the Virulence and Pathogenicity of Pandemic H1N1/2009 Influenza A Virus in Mice. PLoS ONE 2013 Apr 24;8(4):e61397. 8. Genetic Characterization of H1N2 Swine Influenza Virus Isolated in China and Its Pathogenesis and Inflammatory Responses in Mice. Arch Virol 2013 Sep;158(9):1965-72. 9. Pandemic (H1N1) 2009 Virus in Swine Herds, People’s Republic of China. Emerging Infectious Diseases 2011 Sep, 9:17. 10. Response of swine lung to H1N1 swine influenza virus infection revealed by transcription analysis. BMC Genomics 2011, 12:398. 11. Emergence of Novel Reassortant H3N2 Influenza Viruses among Ducks in China. Arch Virol 2011 156:1045-1048. 12. Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain. Journal of Infectious Diseases 2010 Nov 1; 202(9): 1338-46. 13. The Special neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus. PLoS ONE 2009, 17; 4(7): e6277. 14. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol 2009, 154:887-890. 15. Effect Small Interfering RNAs Targeting Matrix (M2) and Nucleocapsid Protein (NP) Gene Inhibits Influenza A Virus Replication in Cells and Mice. Antiviral Research 2007, (76): 186-193. 16. Genome Sequence Analysis of the Pathogenic H5N1 Avian Influenza A Virus Isolated in China in 2004. Virus Genes 2006, 32: 85-95. 17. Duck interferon regulatory factor 1 acts as a positive regulator in duck innate antiviral response. Dev Comp Immunol. 2018 Jan;78:1-13.16. 18. The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3. Front Immunol. 2017 Jul 3;8:779. 19. HIST1H1C Regulates Interferon-β and Inhibits Influenza Virus Replication by Interacting with IRF3. Front Immunol. 2017 Mar 24;8:350. 20. Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses. Sci Rep. 2017 Mar 6;7:43566. 21. Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA. J Immunol. 2016 Dec 15;197(12):4704-4713. 22. 14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses. Antiviral Res. 2016 Sep;133:95-105. 23. Molecular cloning and functional analysis of duck ubiquitin-specific protease 18 (USP18) gene. Dev Comp Immunol. 2016 Sep;62:39-47. 24. 14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes. Antiviral Res. 2015 Jun;118:82-92. 25. Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-β production. Dev Comp Immunol. 2015 May;50(1):49-57. 26. CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. Cell Mol Life Sci. 2015 Mar;72(5):971-82. 27. The 2009 pandemic (H1N1) viruses isolated from pigs show enhanced pathogenicity in mice. Vet Res. 2013 Jun 11;44:41. 28. Investigation of influenza virus polymerase activity in pig cells. J Virol. 2013 Jan;87(1):384-94. 29. Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics. J Proteome Res. 2012 Nov 2;11(11):5396-405. 30. The antigenic property of the H5N1 avian influenza viruses isolated in central China. Virol J. 2012 Aug 6;9:148. 31. Analysis of cellular proteome alterations in porcine alveolar macrophage cells infected with 2009 (H1N1) and classical swine H1N1 influenza viruses. J Proteomics 2011 Dec 20. 32. Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression. PLoS ONE 2011, 6(10): e26175. 33. Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells. Virol J 2011 May 19; 8:240. 34. Proteomics analysis of differential expression of chicken brain tissue proteins in response to neurovirulent H5N1 avian influenza virus infection. J Proteome Res 2010 May 3. 35. Genetic characterization of an H5N1 avian influenza virus with neurovirulence in ducks. Virus Genes 2009, 38(2): 263-8. 36. Evolutionary characterization of influenza virus A/duck/Hubei/W1/2004 (H9N2) isolated from central China. Virus Genes 2008, 36(1):79-83. 37. Generation and Characterization of an H5N1 Avian Influenza Virus Hemagglutinin Glycoprotein Pseudotyped Lentivirus. Journal of Virological Methods 2008, 154: 99-103. 38. Avian Influenza (H5N1) Virus in Waterfowl and Chickens, Central China. Emerging Infectious Diseases 2007, 13(5): 772-775.
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