教育背景
1985.9-1989.6,哲理木畜牧学院(内蒙古民族大学),畜牧学专业毕业,获学士学位1989.9-1992.6, 吉林农业大学,动物遗传育种与繁殖学专业毕业,获硕士学位1995.9-1998.6 , 东北农业大学,动物遗传育种与繁殖学专业毕业,获博士学位
工作经历
1992.7-1995.7 华中农业大学畜牧兽医系,助教1995.9-1998.11 华中农业大学动物科技学院 ,讲师1998.12-2003.10 华中农业大学动物科技学院 ,副教授,副系主任2003.07-- 华中农业大学动物科技学院,教授2005.8-- 华中农业大学动物科技学院,博导,系主任2005.12-- 农业动物遗传育种与繁殖教育部重点实验室,主任2010.11-2019.5 华中农业大学动物科技-动物医学院,副院长2019.06-- 华中农业大学动物科技-动物医学院,院长2016.12-- 国家家畜工程技术研究中心,主任[留学经历]2000.7-2001.7 美国依阿华州立大学动物科学系分子遗传组 访问研究2001.11-2005.5 美国依阿华州立大学动物科学系分子遗传组 Research Associate 2011.10-2012.3 美国康乃尔大学动物科学系遗传生理组 唐氏学者
项目课题经历
论文、成果、著作等
A著作类1.《动物分子生物学》主编,高等教育出版社, ISBN: 978-7-04-029620-4,2010.122.《彭中镇文集》主编,中国农业出版社3.《动物遗传学》参编,高等教育出版社, ISBN:7040267152 9787040267150, 2009.84.《分子遗传学》参编,高等教育出版社5.《普通遗传学》参编,高等教育出版社6.《家畜育种学》参编,中国农业出版社B论文类1.Changzhi Zhao1, 2*, Xiaoguo Zheng3, 4*, Wubin Qu5*, Guanglei Li1, Xinyun Li1, 2, Yi-Liang Miao1, 2, Xiaosong Han1, Xiangdong Liu1, 2, Zhenhua Li3, 4, Yunlong Ma1, Qianzhi Shao5, Haiwei Li5, Fei Sun, Shengsong Xie, and Shuhong Zhao. CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif. International Journal of Biological Sciences 2017; 13(11): 1470-1478. doi: 10.7150/ijbs.21312 2.Xinyi Liu, Yongliang Wang, Liming Hou, Yuanzhu Xiong, and Shuhong Zhao. Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21-SIRT1-AMPK-PGC1α Pathway. Journal of Cellular Physiology. J. Cell. Physiol. 232: 1893–1906, 2017 3.J. Zhang,* J. H. Chen,* X. D. Liu,* H. Y. Wang,*
X. L. Liu,* X. Y. Li,* Z. F. Wu,† M. J. Zhu,*‡2 and S. H. Zhao. Genomewide association studies for hematological traits and
T lymphocyte subpopulations in a Duroc × Erhualian F2 resource population. J. Anim. Sci. 2016.94:5028–5041 4.Liangliang Fu, Yueyuan Xu, Ye Hou, Xiaolong Qi, Lian Zhou, Huiying Liu, Yu Luan, Lu Jing, Yuanxin Miao, Shuhong Zhao, Huazhen Liu & Xinyun Li. Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs. Scientific Reports | 7:45291 | DOI: 10.1038/srep452915.Li C, He H, Liu A, Liu H, Huang H, Zhao C, Jing L, Ni J, Yin L, Hu S, Wu H, Li X, Zhao S. Natural Functional SNPs in miR-155 Alter Its Expression Level, Blood Cell Counts, and Immune Responses. Front Immunol. 2016 Aug 2;7:295. doi: 10.3389/fimmu.2016.00295.6.Yunxia Zhao, Ye Hou, Fei Liu, An Liu, Lu Jing, Changzhi Zhao, Yu Luan, Yuanxin Miao, Shuhong Zhao and Xinyun Li. Transcriptome analysis reveals that vitamin A metabolism in
the liver affects feed efficiency in pigs.
G3: GENES, GENOMES, GENETICS November 1, 2016 vol. 6 no. 11 3615-3624; https://doi.org/10.1534/g3.116.0328397.H. Wang, Y. Hou, J. Guo, H. Chen, X. Liu, Z. Wu, S. Zhao, and M. Zhu Transcriptomic landscape for lymphocyte count variation in poly I:C-induced porcine peripheral blood. Animal Genetics, 26 NOV 2015 . DOI: 10.1111/age.123798.Wei W, Zhang WY, Bai JB, Zhang HX, Zhao YY, Li XY, Zhao SH. The NF-ҡB modulated miR-195/497 inhibit myoblast proliferation by targeting Igf1r/Insr and cyclin genes. J Cell Sci. (2016) 129, 39-50 doi:10.1242/jcs.174235 9.Ruiyi Lin1, Di Wu1, 2, Changzhi Zhao1, Shangshang Chen1, Qian Xiao1, Changchun Li1, Xinyun Li1, Shuhong Zhao.*Inducible overexpression of porcine Homeobox A10 in the endometrium of transgenic mice. Journal of Integrative Agriculture (JIA) , Doi: 10.1016/S2095-3119(15)61169-8 10.Lu Jing, Ye Hou, Hui Wu, Yuanxin Miao, Xinyun Li, Jianhua Cao, John Michael Brameld, Tim Parr & Shuhong Zhao. Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs. Scientific Reports, 2015, 5:11953(1-14). DOI: 10.1038/srep1195311.Xiaoyong Du, Bertrand Servin2†, James E Womack3, Jianhua Cao1, Mei Yu1, Yang Dong4,5, Wen Wang, and Shuhong Zhao. An update of the goat genome assembly using dense radiation hybrid maps allows detailed analysis of evolutionary rearrangements in Bovidae. Du et al. BMC Genomics, 2014, 15:625 (page 1-16)12.Guanglei Li1, Qitao Jia2, Jianguo Zhao2, Xinyun Li1, Mei Yu1, Melissa S Samuel3, Shuhong Zhao, Randall S Prather. and Changchun Li. Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets. BMC Genomics, 2014, 15:811(pages 1-14)13.The FAANG Consortium*, Leif Andersson, Alan L. Archibald, Cynthia D. Bottema, Rudiger Brauning, Shane C. Burgess, Eduardo Casas, Hans H. Cheng, Laura Clarke, Christine Couldrey, Brian P. Dalrymple, Christine G. Elsik, Sylvain Foissac, Elisabetta Giuffra§, Martien A. Groenen, Ben J. Hayes, LuSheng S. Huang, Hassan Khatib, James W. Kijas, Heebal Kim,Joan K. Lunney, Fiona M. McCarthy, John C. McEwan, Stephen Moore, Bindu Nanduri, Cedric Notredame, Yniv Palti, Graham S. Plastow, James M. Reecy, Gary A. Rohrer, Elena Sarrapoulou, Carl J. Schmidt, Jeff Silverstein, Ross L. Tellam, Michele Tixier-Boichard, Gwenola Tosser-Klopp, Christopher K. Tuggle§, Johanna Vikki, Stephen White, Shuhong Zhao, Huaijun Zhou. Coordinated international action to accelerate Genome to Phenome- The Functional Annotation of ANimal Genomes (FAANG) Project. Genome Biol. 2015 Mar 25;16:57(pages 1-6). doi: 10.1186/s13059-015-0622-4.14.Ting Gu1, Meng-jin Zhu1, Martine Schroyen2, Long Qu3, Dan Nettleton3, Dan Kuhar4, Joan K Lunney4, Jason W Ross2, Shu-hong Zhao (共同通讯作者) and Christopher K Tuggle2*. Endometrial gene expression profiling in pregnant Meishan and Yorkshire pigs on day 12 of gestation. BMC Genomics 2014, 15:156 (1-12)15.Jing Huang a,b, Guojian Mac,1, Liangliang Fu a, Hao Jia a, Mengjin Zhu a, Xinyun Li a, Shuhong Zhao (通讯作者) Pseudorabies viral replication is inhibited by a novel target of miR-21. Virology 456-457 (2014) 319–32816.Zhao M, Liu XD, Li XY, Chen HB, Jin H, Zhou R, Zhu MJ, Zhao SH. Systems infection biology: a compartmentalized immune network of pig spleen challenged with Haemophilus parasuis. BMC Genomics. 2013 Jan 22;14:46. doi: 10.1186/1471-2164-14-46.17.Y Feng, L-L Niu, W Wei, W-Y Zhang, X-Y Li, J-H Cao and S-H Zhao (通讯作者). A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation Cell Death and Disease (2013) 4, e934; doi:10.1038/cddis.2013.46218.W Wei, H-B He, W-Y Zhang, H-X Zhang, J-B Bai, H-Z Liu, J-H Cao, K-C Chang, X-Y Li and S-H Zhao. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. Cell Death and Disease (2013) 4, e668; doi:10.1038/cddis.2013.18419.Dawson HD, Loveland JE, Pascal G, Gilbert JG, Uenishi H, Mann KM, Sang Y, Zhang J, Carvalho-Silva D, Hunt T, Hardy M, Hu Z, Zhao SH, Anselmo A, Shinkai H, Chen C, Badaoui B, Berman D, Amid C, Kay M, Lloyd D, Snow C, Morozumi T, Cheng RP, Bystrom M, Kapetanovic R, Schwartz JC, Kataria R, Astley M, Fritz E, Steward C, Thomas M, Wilming L, Toki D, Archibald AL, Bed'Hom B, Beraldi D, Huang TH, Ait-Ali T, Blecha F, Botti S, Freeman TC, Giuffra E, Hume DA, Lunney JK, Murtaugh MP, Reecy JM, Harrow JL, Rogel-Gaillard C*, Tuggle CK*.Structural and functional annotation of the porcine immunome. BMC Genomics. 2013 May 15;14:332. doi: 10.1186/1471-2164-14-332.20.Liu G, Liu R, Li Q, Tang X, Yu M, Li X, Cao J, Zhao S (共同通讯作者). Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep, PLOS ONE, 2013,DOI: 10.1371/journal.pone.0077801 21.Shuhong Zhao, Mengjin Zhu, and Hongbo Chen. Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli. Journal of Animal Science and Biotechnology 2012, 3:3422.Yang S, He M, Liu X, Li X, Fan B, Zhao S (共同通讯作者). Japanese encephalitis virus infects porcine kidney epithelial PK15 cells via clathrin- and cholesterol-dependent endocytosis. Virol J. 2013 Aug 12;10:258. doi: 10.1186/1743-422X-10-258.23.Yang S, Liu X, Li X, Sun S, Sun F, Fan B, Zhao S (共同通讯作者) MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells. Mol Cell Biochem. 2013 Dec;384(1-2):213-9. doi: 10.1007/s11010-013-1800-x24.Di Wu, Dechao Song, Xinyun Li, Mei Yu, Changchun Li & Shuhong Zhao. Molecular characterization and identification of the E2/P4 response element in the porcine HOXA10 gene. Mol Cell Biochem. 2013 Feb;374(1-2):213-22. DOI 10.1007/s11010-012-1522-525.Congcong Li, Huabin He, Mengjin Zhu, Shuhong Zhao, Xinyun Li. Molecular characterisation of porcine miR-155 and its regulatory roles in the TLR3/TLR4 pathways. Dev Comp Immunol. Volume 39, Issues 1–2, January–February 2013, Pages 110–11626.Yang Dong, Min Xie, Yu Jiang, Nianqing Xiao, Xiaoyong Du, Wenguang Zhang, Gwenola Tosser-Klopp, Jinhuan Wang, Shuang Yang, Jie Liang, Wenbin Chen, Jing Chen, Peng Zeng, Yong Hou, Chao Bian, Shengkai Pan, Yuxiang Li, Xin Liu, Wenliang Wang, Bertrand Servin, Brian Sayre, Bin Zhu, Deacon Sweeney, Rich Moore, Wenhui Nie, Yongyi Shen, Ruoping Zhao, Guojie Zhang, Jinquan Li, Thomas Faraut, James Womack, Yaping Zhang, James Kijas, Noelle Cockett, Xun Xu, Shuhong Zhao(共同通讯作者), Jun Wang & Wen Wang. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus),Nature Biotechnology,(2012) doi:10.1038/nbt.247827.Groenen MA*, Archibald AL*, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF, Rogel-Gaillard C, Park C, Milan D, Megens HJ, Li S, Larkin DM, Kim H, Frantz LA, Caccamo M, Ahn H, Aken BL, Anselmo A, Anthon C, Auvil L, Badaoui B, Beattie CW, Bendixen C, Berman D, Blecha F, Blomberg J, Bolund L, Bosse M, Botti S, Bujie Z, Bystrom M, Capitanu B, Carvalho-Silva D, Chardon P, Chen C, Cheng R, Choi SH, Chow W, Clark RC, Clee C, Crooijmans RP, Dawson HD, Dehais P, De Sapio F, Dibbits B, Drou N, Du ZQ, Eversole K, Fadista J, Fairley S, Faraut T, Faulkner GJ, Fowler KE, Fredholm M, Fritz E, Gilbert JG, Giuffra E, Gorodkin J, Griffin DK, Harrow JL, Hayward A, Howe K, Hu ZL, Humphray SJ, Hunt T, Hornshøj H, Jeon JT, Jern P, Jones M, Jurka J, Kanamori H, Kapetanovic R, Kim J, Kim JH, Kim KW, Kim TH, Larson G, Lee K, Lee KT, Leggett R, Lewin HA, Li Y, Liu W, Loveland JE, Lu Y, Lunney JK, Ma J, Madsen O, Mann K, Matthews L, McLaren S, Morozumi T, Murtaugh MP, Narayan J, Nguyen DT, Ni P, Oh SJ, Onteru S, Panitz F, Park EW, Park HS, Pascal G, Paudel Y, Perez-Enciso M, Ramirez-Gonzalez R, Reecy JM, Rodriguez-Za
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