首页 > 专家库
彭贵青

领域:现代农业 学校:华中农业大学职称:教授

从事分子病毒学及蛋白质结构生物学研究,研究方向包括重要病原体入侵及其与宿主相互作用的分子机理;病原体耐药分子机理;新型抗病毒药物和诊断方法的开发与研制。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1997.09 - 2001.06, 华中农业大学,兽医专业毕业,学士学位2001.09 - 2004.06, 华中农业大学,预防兽医学毕业,硕士学位2004.09 - 2007.06, 武汉大学,微生物学专业毕业,理学博士学位

工作经历

2007.11-2008.10,中国科学院武汉病毒学研究所 助理研究员2009.01-2012.07,美国明尼苏达大学药学院 博士后2012.08- 至今,华中农业大学“楚天学者特聘教授”,博士生导师,农业微生物学国家重点实验室固定人员

项目课题经历

论文、成果、著作等

2011年以来发表的文章:
1. Shen Z, Ye G, Deng F, Wang G, Cui M, Fang L, Xiao S, Fu ZF, Peng G*.Structural basis for the inhibition of host gene expression by porcine epidemic diarrhea virus nsp1. J Virol.(in press)
2. Shi Y, Lei Y, Ye G, Sun L, Fang L, Xiao S, Fu ZF, Yin P, Song Y*, Peng G*. Identification of Two Antiviral Inhibitors Targeting 3C-like Serine/3C-like Protease of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Epidemic Diarrhea Virus. Veterinary Microbiology. Volume 213, January 2018, Pages 114–122
3. Zeng Z, Li TT, Jin X, Peng FH, Song NH, Peng GQ*, Ge XY*. Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016. Virol Sin. 2017 Aug;32(4):298-306.
4. Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S. Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2. J Virol. 2017 Apr 28;91(10). pii: e00003-17.
5. Peng G, Yang Y, Pasquarella JR, Xu L, Qian Z, Holmes KV, Li F.Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor. J Biol Chem. 2017 Feb 10;292(6):2174-2181.
6. Fang J, Li H, Kong D, Cao S, Peng G, Zhou R, Chen H, Song Y.Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus. Sci Rep. 2016 Sep 29;6:34550.
7. Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, Fu ZF, Peng G*. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology. 2016 Jul;494:225-35.
8. Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, Luo R, Wang D, Fu ZF, Xiao S, Peng G*. A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of PRRSV nsp11. J Virol. 2016 Feb 24. pii: JVI.03065-15.
9. Wang J, Deng F, Ye G, Dong W, Zheng A, He Q, Peng G*. Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses. Virol Sin. 2016 Feb;31(1):49-56.
10. Deng F, Ye G, Liu Q, Navid MT, Zhong X, Li Y, Wan C, Xiao S, He Q*, Fu ZF*, Peng G*. Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains. Viruses. 2016 Feb 23;8(3). pii: E55.
11. Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G*, Zhao L*. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol. 2016 Jan 12.
12. Li Y, Dong W, Shi Y, Deng F, Chen X, Wan C, Zhou M, Zhao L, Fu ZF*, Peng G*. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Virology. 2016 Jan 15;488:216-24.
13. Wang D,Fang L,Shi Y,Zhang H,Gao L,Peng G,Chen H,Li K,Xiao S.Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO,J Virol. 2015,90(4):2090-2101.
14. Dong W, Huang J, Li Y, Tan Y, Shen Z, Song Y, Wang D, Xiao S, Chen H, Fu ZF*, Peng G*. Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep. 2015 Oct 15;5:15073.
15. Liu C,Tang J,Ma Y,Liang X,Yang Y,Peng G,Qi Q,Jiang S,Li J,Du, L,Li F. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus,J Virol. 2015,89(11):6121-6125.
16. Zhang Y, Li H, Peng G, Zhang Y, Gao X, Xiao S, Cao S, Chen H, Song Y.Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus non-structural protein 10.J Gen Virol. 2015 Mar;96(Pt 3):547-52. doi: 10.1099/jgv.0.000004. Epub 2014 Dec 5.
17. Zhang H, Li X, Peng G, Tang C, Zhu S, Qian S, Xu J, Qian P.Glycoprotein E2 of classical swine fever virus expressed by baculovirus induces the protective immune responses in rabbits.Vaccine. 2014 Nov 20;32(49):6607-13.
18. Fang J, Sun L, Peng G, Xu J, Zhou R, Cao S, Chen H, Song Y.Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280.PLoS One. 2013 Nov 4;8(11):e78425.
19. Fang J, Li H, Peng G, Cao S, Zhen FF, Chen H, Song Y.Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.J Virol Methods. 2013 Dec;194(1-2):33-8.
20. Peng G, Xu L, Chen L, Lin YL, Chen L, Pasquarella JR, Holmes KV, Li F. Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012. Dec 7;287(50):41931-8.
21. Chen L, Lin YL, Peng G, Li F. Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl AcadSci U S A. 2012 Oct 30;109(44):17966-71.
22. Wu K#, Peng G# (Co-first author), Wilken M#, Geraghty RJ, Li F. Mechanism of Host Receptor Adaptation by SARS Coronavirus. J Biol Chem. 2012 ;287(12):8904-11.
23. Peng G, Sun D, Rajashankar K, Qian Z, Holmes K, Li F. Structure of mouse coronavirus galectin-likedomain complexed with its protein receptor. Proc Natl AcadSci U S A. 2011 Jun 16, 108, 10696-10701.
24. Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F.A Virus-binding Hotspot on Human Angiotensin-converting Enzyme 2 is Critical for the Binding of Two Different Coronaviruses. J Virol. 2011 Mar; 85, 5331-5337.

专利、著作版权等

声明:本站专家信息来源于各高校官网。