教育背景
1991.09 - 1995.07, 湖北省中医药大学,中药毕业,医学学士1995.09 - 1998.07, 河南省中医药大学,药物化学专业毕业,医学硕士1998.09 – 2001.07,中国科学院上海药物研究所,有机化学专业,理学博士
工作经历
2001.09-2003.10,瑞典Lund University细胞与分子生物学系,博士后2003.10-2013.01,美国费城Thomas Jefferson University生化与分子生物学系,先后为博士后与助理研究人员2013.01-至今, 华中农业大学动物医学院,教授
项目课题经历
论文、成果、著作等
A著作类1.《动物生物化学》教材,2016年,高等教育出版社, 参编,撰写“酶”一章。B论文类Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res. 2017 Apr 20;45(7):4081-4093. doi: 10.1093/nar/gkw1229.Li M, Cai C, Chen J, Cheng C, Cheng G, Hu X, Liu C (Correspondence author). Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China. Int J Mol Sci. 2016 Sep 22;17(10). pii: E1599. doi: 10.3390/ijms17101599.Liu C(Co-1st author), Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X. Molecular Basis and consequences of the cytochrome c-tRNA interaction. Journal of Biological Chemistry. 2016; Mar 9. pii: jbc.M115.697789.Kalamajski S, Liu C, Tillgren V, Rubin K, Oldberg Å, Rai J, Weis M, Eyre DR. Increased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice. Journal of Biological Chemistry. 2014; 289(27): 18873-9. Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). Journal of Biological Chemistry. 2013; 288(40): 28987-96.Liu C, Sanders J, Pascal J, Hou YM, Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases, RNA, 2012, 18(2): 213-21 Liu C, Gamper H., Liu H., Cooperman BS, Hou YM, Potential for the interdependent deve-lopment for aminoacylation and ribosome decoding, Nature Communications, 2011, 2 : 329Igarashi T, Liu C (co-1st author), Hou YM, Pyrophosphorolysis of class II CCA addition: Implication for Fidelity, Journal of Molecular Biology, 2011, 414(1):28-43Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM, Mechanism of N-methylation by the tRNA m1G methyltransferase Trm5. RNA. 2010, 16(12): 2484-92McLaughlin HM, Sakaguchi R, Liu C, Igarashi T, Pehlivan D, Chu K, Iyer R, Cruz P, et al., Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy. American Journal of Human Genetics. 2010, 87(4):560-6Christian T, Lahoud G, Liu C, Hou YM, Control of catalytic cycle by a pair of analogous tRNA modification enzymes. Journal of Molecular Biology. 2010, 400(2): 204-17 Liu C, Betteridge, T, Hou, YM. Fluorophore labeling to monitor tRNA dynamics. Methods Enzymol. (Editor Herschlag, D, Academic Press) 2009, 469: 69-93Kim S, Liu C, Halkidis K, Gamper HB, Hou YM, Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA. 2009, 15(10):1827-36Liu X, Silks LA, Liu C, Ollivault-Shiflett M., Huang X, Li J, Luo G, Hou YM, Liu J, Shen J. Incorporation of tellurocysteine into glutathione transferase generate high glutathione peroxidase efficiency. Angew Chem Int Ed Engl, 2009, 48(11): 2020-3Zhang CM, Liu C (co-1st author), Slator S and Hou YM, Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys), Nature Structural & Molecular Biology, 2008, 15(5):507-14Zhang CM, Liu C, Christian T, Gamper H, Rozenski J, Pan D, Randolph JB, Wickstrom E, Cooperman BS, and Hou YM, Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3
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