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霍立军

领域:现代农业 学校:华中农业大学职称:教授

哺乳动物卵子成熟调控机制,成熟卵子质量控制和影响因素。...

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教育背景

1995.09-1999.09,东北农业大学,生物技术系,理学学士1999.09-2002.09,东北农业大学,生命科学学院,基础兽医学硕士2002.09-2005.09,中国科学院动物研究所,计划生育生殖生物学国家重点实验室,理学博士2005.09-2008.09,Stowers Institute for Medical Research,博士后,导师:Scott Hawley

工作经历

2008.08-至今,华中农业大学教授、博士生导师,动物繁殖与特经系副系主任。

项目课题经历

论文、成果、著作等

A著作类1.《小鼠胚胎操作实验手册》,孙青原,陈大元主译。霍立军编译“植入前胚胎的收集和体外培养”一章。化学工业出版社B论文类(#第一作者,*通讯作者)Ding ZM#, Jiao XF, Wu D, Zhang JY, Chen F, Wang YS, Huang CJ, Zhang SX, Li X, Huo LJ*. Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage. Chem Biol Interact. 2017 Nov 1. pii: S0009-2797(17)31017-7. Brohi RD#, Wang L, Talpur HS, Wu D, Khan FA, Bhattarai D, Rehman ZU, Farmanullah F, Huo LJ*. Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review. Front Pharmacol. 2017 Sep 5;8:606. doi: 10.3389/fphar.2017.00606. eCollection 2017. Review.Brohi RD#, Wang L, Hassine NB, Cao J, Talpur HS, Wu D, Huang CJ, Rehman ZU, Bhattarai D, Huo LJ*. Expression, Localization of SUMO-1, and Analyses of Potential SUMOylated Proteins in Bubalus bubalis Spermatozoa. Front Physiol. 2017 Jun 13;8:354. doi: 10.3389/fphys.2017.00354.Ding ZM#, Huang CJ, Jiao XF, Wu D, Huo LJ*. The role of TACC3 in mitotic spindle organization. Cytoskeleton (Hoboken). 2017 Jul 26. doi: 10.1002/cm.21388. Brohi RD#, Huo LJ*. Posttranslational Modifications in Spermatozoa and Effects on Male Fertility and Sperm Viability. OMICS: A Journal of Integrative Biology. 2017 May;21(5):245-256. Wu D#, Huang CJ, Khan FA, Jiao XF, Liu XM, Pandupuspitasari NS, Brohi RD, Huo LJ*. SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. Oncotarget. 2017 Apr 7. doi: 10.18632/oncotarget.16915. Huang CJ#, Wu D, Jiao XF, Khan FA, Xiong CL, Liu XM, Yang J, Yin TL, Huo LJ*. Maternal SENP7 programs meiosis architecture and embryo survival in mouse. Biochim Biophys Acta. 2017 Mar 16;1864(7):1195-1206. doi: 10.1016/j.bbamcr.2017.03.005. Jiao XF*, Huang CJ, Wu D, Zhang JY, Long YT, Chen F, Li X, Huo LJ#. Abce1 orchestrates M-phase entry and cytoskeleton architecture in mouse oocyte. Oncotarget. 2017 Mar 24. doi: 10.18632/oncotarget.16546. Wang L#, Zhen Y, Liu X, Cao J, Wang Y, Huo L*. Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium. PeerJ 2017 Feb 23 5:e3032 doi: 10.7717/peerj.3032.Huang CJ#, Yuan YF, Wu D, Khan FA, Jiao XF, Huo LJ*. The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis. In Vitro Cell Dev Biol Anim. 2017 Mar;53(3):258-264. Yang, Feifei#,Xiong, Jiajun,Liu, Xiaoming,Riaz, Hasan,Wang, Li,Cao, Jing,Khan, Faheem Ahmed,Huo, Lijun*,SUMOylation of PTX3 at Lysine 203 Regulates its Subcellular Localization in Mouse Ovarian Granulosa Cells. Pakistan Veterinary Journal. 2017.01.01,37(1):25~30Huang C#, Wu D, Khan FA, Jiao X, Guan K, Huo L*. The GTPase SPAG-1 orchestrates meiotic program by dictating meiotic resumption and cytoskeleton architecture in mouse oocytes. Mol Biol Cell. 2016 Jun 1;27(11):1776-85. Huang CJ#, Wu D, Khan FA, Huo LJ*. The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes. Sci Rep. 2015 Oct 23;5:15600.Huang CJ#, Wu D, Khan FA, Huo LJ*. DeSUMOylation: An Important Therapeutic Target and Protein Regulatory Event. DNA Cell Biol. 2015 Nov;34(11):652-60. Khan HA#, Zhao Y, Wang L, Li Q, Du YA, Dan Y, Huo LJ*. Identification of miRNAs during mouse postnatal ovarian development and superovulation. J Ovarian Res. 2015 Jul 8;8(1):44. Yuan YF#, Zhai R, Liu XM, Khan HA, Zhen YH, Huo LJ*. SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation. Mol Reprod Dev. 2014 Aug;81(8):712-24.Zhen YH#, Wang L, Riaz H, Wu JB, Yuan YF, Han L, Wang YL, Zhao Y, Dan Y, Huo LJ*. Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis. J Steroid Biochem Mol Biol. 2014 Mar 4;143C:90-98. Liu XM#, Yang FF, Yuan YF, Zhai R, Huo LJ*. SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. PLoS One. 2013 May 16;8(5):e63680. Zhai R#, Yuan YF, Zhao Y, Liu XM, Zhen YH, Yang FF, Wang L, Huang CZ, Cao J, Huo LJ*. Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Mol Reprod Dev. 2013 Jun;80(6):474-87. Huo L-J#, Fan H-Y, Liang C-G, Yu L-Z, Zhong Z-S, Chen D-Y, Sun Q-Y*. Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization. Biol Reprod 2004; 71:853-62.Huo L-J#, Fan H-Y, Zhong Z-S, Chen D-Y, Schatten H, Sun Q-Y*. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Mech Dev 2004; 121:1275-87.Huo L-J#, Liang C-G, Yu L-Z, Zhong Z-S, Yang Z-M, Fan H-Y, Chen D-Y, Sun Q-Y*. Inducible nitric oxide synthase-derived nitric oxide regulates germinal vesicle breakdown and first polar body emission in the mouse oocyte. Reproduction 2005; 129:403-9.Huo L-J#, Ma X-H, Yang Z-M*. Assessment of sperm viability, mitochondrial activity, capacitation and acrosome intactness in extended boar semen during long-term storage. Theriogenology 2002; 58:1349-60.Huo LJ#, Yang ZM*. Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. Mol Reprod Dev 2000; 56:436-40.Huo L-J#, Yu L-Z, Liang C-G, Fan H-Y, Chen D-Y, Sun Q-Y*. Cell-cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse. Zygote 2005; 13:45-53.Huo L-J#, Yue K-Z, Yang Z-M*. Characterization of viability, mitochondrial activity, acrosomal integrity and capacitation status in boar sperm during in vitro storage at different ambient temperatures. Reprod Fertil Dev 2002; 14:509-14.Huo L-J#, Zhong Z-S, Liang C-G, Wang Q, Yin S, Ai J-S, Yu L-Z, Chen D-Y, Schatten H, Sun Q-Y*. Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. Front Biosci 2006; 11:2193-202.

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