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何启盖

领域:现代农业 学校:华中农业大学职称:教授

猪传染病临床诊断和控制、致病机制、新型疫苗与诊断制剂。...

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教育背景

1984.09 - 1989.06, 西南民族大学,兽医专业毕业,医学学士1990.09 - 1993.06, 四川农业大学,传染病学与预防兽医学专业毕业,农学硕士1996.09-2000.06,华中农业大学,动物遗传育种与繁殖(抗病方向),农学博士

工作经历

1993.06-2002.11,华中农业大学助教、讲师,副教授,硕士生导师。2002.11-2006.03,新加坡国立大学访问学者和博士后2006.04-现在,华中农业大学教授,硕士和博士生导师

项目课题经历

论文、成果、著作等

A著作类1. 主编之一,《伪狂犬病》,中国农业出版社,20152. 副主编,《兽医手册》(中国农业出版社)和《中国生猪产业技术进展》(湖南科学技术出版社);副主译《生物安全选集XI》(中国农业出版社)。3.参编(译),《默克兽医手册》(中国农业出版社)、《人兽共患病学》(四川科学技术出版社) B论文类Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae. FEMS Microbiol Lett. 2009 Nov; 300(1):83-9. Yang W, Pin C, Haibing G, Yang C, Hui L, Qigai H. Loop-mediated isothermal amplification targeting the apxIVA gene for detection of Actinobacillus pleuropneumoniae.; FEMS Microbiol Lett. 2009 Nov; 300(1):83-9Wang Yang, Fang Ying, Liu Yingyu, Chen Pin, Li Wentao, Liu Shuqing, Zou Haoyong, He Qigai. Development and evaluation of loop-mediated isothermal amplification for rapid detection of Haemophilus parasuis. FEMS Microbiology Letters, 2010, 313(1):54-60Huimin Zhang, Wentao Li, Zonghai Sheng, Heyou Han and Qigai He. Ultrasensitive detection of porcine circovirus type 2 using gold (III) enhanced chemiluminescence immunoassay. Analyst, 2010,135(7):1680-1685Chen H, Cheng L, Yang S, Liu X, Liu Y, Tang J, Li X, He Q, Zhao S. Molecular characterization, induced expression, and transcriptional regulation of porcine S100A12 gene. Mol Immunol. 2010 Apr; 47(7-8):1601-7.Pin Chen,Yingyu Liu,Chong Liu,Haoyong Zou,Yang Wang,Wentao Li,Dingren Bi and Qigai He. Laboratory Detection of Haemophilus parasuis with Decreased Susceptibility to Nalidixic Acid and Enrofloxacin Due to GyrA and ParC Mutations. Journal of Animal and Veterinary Advances. 2011, 10(21):2870-2873Hao-Yong Zou, Xin-Jun Liu, Feng-Ying Ma, Pin Chen, Rui Zhou, Qi-Gai He. Attenuated Actinobacillus pleuropneumoniae as a bacterial vector for expression of Mycoplasma hyopneumoniae P36 gene. The Journal of Gene Medicine. 2011, 13(4):221-229Zhao Z, Wang C, Xue Y, Tang X, Wu B, Cheng X, He Q, Chen H. The occurrence of Bordetella bronchiseptica in pigs with clinical respiratory disease.Vet J. 2011 Jun; 188(3):337-40.Wang Y, Liu C, Fang Y, Liu X, Li W, Liu S, Liu Y, Liu Y, Charreyre C, Audonnet JC, Chen P, He Q. Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. BMC Genomics. 2012 Feb 13;13:68Cheng S, Zhang M, Li W, Wang Y, Liu Y, He Q; Proteomic analysis of porcine alveolar macrophages infected with porcine circovirus type 2; J Proteomics. 2012 Jun 18;75(11):3258-69Yingyu Liu, Pin Chen, Yang Wang, Wentao Li, Shuang Cheng, Chunmei Wang, Anding Zhang, Qigai He;Transcriptional profiling of Haemophilus parasuis SH0165 response to tilmicosin. Microbial Drug Resist. 2012 Dec;18(6):604-15Liu C, Wang Y, Zhang H, Cheng S, Charreyre C, Audonnet JC, Chen P, He Q. Porcine coronin 1A contributes to nuclear factor-kappa B (NF-κB) inactivation during Haemophilus parasuis infection. PLoS One. 2014 Aug 5; 9(8):e103904.Hu H, Wang C, Guo X, Li W, Wang Y, He Q. Broad activity against porcine bacterial pathogens displayed by two insect antimicrobial peptides moricin and cecropin B. Mol Cells. 2013 Feb; 35(2):106-14Li W, Liu S, Wang Y, Deng F, Yan W, Yang K, Chen H, He Q, Charreyre C, Audoneet JC. Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2. BMC Genomics. 2013 May 27; 14:35310.Cheng S, Yan W, Gu W, He Q. The ubiquitin-proteasome system is required for early stages of porcine circovirus type 2 replication. Virology. 2014 May; 456-457:198-204.Chen F, Hu H, Li Z, Huang J, Cai X, Wang C, et al. Deletion of HAPS_2096 Increases Sensitivity to Cecropin B in Haemophilus parasuis. J Mol Microbiol Biotechnol 2015;25:284-91.Chen F, Zhu Y, Wu M, Ku X, Yao L, He Q. Full-Length Genome Characterization of Chinese Porcine Deltacoronavirus Strain CH/SXD1/2015. Genome Announc 2015;3.Chen F, Zhu Y, Wu M, Ku X, Ye S, Li Z, et al. Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea Virus. Viruses 2015;7:5525-38.Guo X, Hu H, Chen F, Li Z, Ye S, Cheng S, et al. iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. J Proteomics 2016;130:65-75.Li W, Wicht O, van Kuppeveld FJ, He Q, Rottier PJ, Bosch BJ. A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion. J Virol 2015;89:8077-81.Ye S, Li Z, Chen F, Li W, Guo X, Hu H, et al. Porcine epidemic diarrhea virus ORF3 gene prolongs S-phase, facilitates formation of vesicles and promotes the proliferation of attenuated PEDV. Virus Genes 2015;51:385-92.Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q, et al. Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter. ACS Appl Mater Interfaces 2015;7:21571-9.Li, Z., Chen, F., Ye, S., Guo, X., Muhanmmad Memon, A., Wu, M. & He, Q. (2016). Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain. Viruses 8, 323.Chen, F., Ku, X., Li, Z. & other authors (2016). Genetic characteristics of porcine epidemic diarrhea virus in Chinese mainland, revealing genetic markers of classical and variant virulent parental/attenuated strains. Gene 588, 95-102.Deng, F., Ye, G., Liu, Q. & other authors (2016). Identification and comparison of receptor binding characteristics of the spike protein of two porcine epidemic diarrhea virus strains. Viruses 8, 55.Guo, X., Hu, H., Chen, F., Li, Z., Ye, S., Cheng, S., Zhang, M. & He, Q. (2016). iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. Journal of proteomics 130, 65-75.Li, W., van Kuppeveld, F. J., He, Q., Rottier, P. J. & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus research 226, 117-127.Guo, X., Zhang, M., Zhang, X. & other authors (2017). Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication. Viruses 9, 53.Li, W., Luo, R., He, Q., van Kuppeveld, F. J., Rottier, P. J. & Bosch, B.-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus research 235, 6-13.Memon AM, Bhuyan AA, Chen F, Guo X, Menghwar H, Zhu Y, Ku X, Chen S, Li Z, He Q. (2017). Development and Validation of Monoclonal Antibody-Based Antigen Capture ELISA for Detection of Group A Porcine Rotavirus.Viral Immunol. 30(4):264-270. Lei Z, Liu Q, Yang B, Ahmed S, Xiong J, Song T, Chen P, Cao J, He Q.(2017).Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs.Front Vet Sci. May 1;4:61.Lei Z, Liu Q, Yang B, Xiong J, Li K, Ahmed S, Hong L, Chen P, He Q, Cao J.(2017). Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs.Front Pharmacol.23;8:294. 

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