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陈小冬

领域:现代农业 学校:华中农业大学职称:副教授

动物代谢与肉品质、脂肪代谢功能基因研究,动物代谢疾病的分子机理。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1994.09-1998.06,湖南农业大学,淡水渔业专业毕业,农学学士1998.09-2004.06,华中农业大学,生物化学与分子生物学专业毕业,理学博士

工作经历

2003.06-2004.05,杜伊斯堡-埃森综合大学,埃森医学院,合作研究2004.07-2006.12,华中农业大学生命科学与技术学院,讲师2007.01-2018.09,华中农业大学生命科学与技术学院,副教授,硕士生导师2013.11-2014.11,美国康奈尔大学,动物科学系,访问学者2018.10-至今,华中农业大学基础兽医系,副教授,硕士生导师

项目课题经历

论文、成果、著作等

A著作类
1. 《硒与人类健康》,科学出版社,2018年9月第一次印刷,参与编译章节排第一。
2.《生物化学技术实验》百门精品课程建设,2014年,排第三。
3. 参与编写《生物化学技术实验》教材,华中农业大学规划教材,2016,排第六。
B论文类
1. Chen XD, Zhao ZP, Zhou JC, Lei XG. Evolution, regulation, and function of porcine selenogenome. Free Radical Biology and Medicine. 2018; 127: 116-123.
2. Zheng HL, Dong XK, Liu N, Xia WM, Zhou LL, Chen XJ, Yang ZQ, Chen XD*. Regulation and mechanism of mouse miR-130a/b in metabolism-related inflammation. Int J Biochem CIell Biol. 2016; 74: 72-83.
3. Wang SB, Lei T, Zhou LL, Zeng CP, Zheng HL, Liu N, Yang ZQ, Chen XD*. Functional analysis and transcriptional regulation of porcine six transmembrane epithelial antigen of prostate 4 (STEAP4) gene and its novel variant in hepatocytes. Int J Biochem Cell Biol. 2013; 45(3): 612-620.
4. Zhang Y, Lei T, Huang JF, Wang SB, Zhou LL, Yang ZQ, Chen XD*. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Molecular and Cellular Endocrinology 2011; 342(1-2): 41-47.
5. Lei T, Bi Y, Gao MJ, Gao SM, Zhou LL, Zheng HL, Chen XD*. HES1 inhibits adipogenesis of porcine mesenchymal stem cells via transcriptional repression of FAD24. Domest Anim Endocrinol. 2013; 45(1): 28-32.
6. Chen XD, Chen YL, Wang SB, Lei T, Gan L, Yang ZQ*. Molecular Characterization and functional analysis of porcine macrophage migration inhibitory factor (MIF) gene. Cytokine. 2010; 50(1): 84-90.
7. Chen XD, Lei T, Xia T, Gan L, Yang ZQ. Increased expression of resistin and tumour necrosis factor-alpha in pig adipose tissue as well as effect of feeding treatment on resistin and cAMP pathway. Diabetes Obes Metab. 2004; 6: 271-279.
8.Chen A, Chen XD, Cheng SQ, Shu L, Yan MP, Yao L, Wang BY, Huang SG, Zhou L, Liu GQ. FTO promotes SREBP1c maturation and enhances CIDEc transcription during lipid accumulation in HepG2 cells. BBA-Molecular and Cell Biology of Lipids. 2018; 1863: 538-548.
9. Feng SQ, Chen XD, Xia T, Gan L, Dai MH, Qiu H, Peng Y, Lei T, Yang ZQ. Cloning, chromosome mapping and expression pattern of pig angptl3 and angptl4. Cytogenetic and Genome Research. 2006; 114: 44-49.
10. Zhang J, Lei T, Chen XD, Peng Y, Long H, Zhou L, Huang J, Chen ZL, Long QQ, Yang ZQ. Resistin Up-Regulates COX-2 Expression via TAK1-IKK- NF-kappaB Signaling Pathway. Inflammation 2010; 33: 25-33.
11. Chen ZL, Lei T, Chen XD, Zhang J, Yu A, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Porcine KLF gene family: Structure, mapping, and phylogenetic analysis. Genomics 2010; 95: 111-119.
12. Qiu H, Xia T, Chen XD, Zhao XL, Gan L, Feng SQ, Lei T, Yang ZQ. Cloning, comparative characterization of porcine SCAP gene, and identification of its two splice variants. Mol Genet Genomics. 2006; 276: 187-196.
13. Dai MH, Xia T, Chen XD, Gan L, Feng SQ, Qiu H, Peng Y, Yang ZQ. Cloning and characterization of porcine resistin gene. Domest Anim Endocrinol. 2006; 30(2):88-97.
14. Qiu H, Xia T, Chen XD, Gan L, Feng SQ, Lei T, Dai MH, Yang ZQ. Characterization of pig INSIG1 and assignment to SSC18. Anim Genet. 2005; 36(3):284-6.
15. Qiu H, Xia T, Chen XD, Feng SQ, Gan L, Lei T, Peng Y, Zhang GD, Nie T, Yue GP, Zhao XL, Yang ZQ. Sequencing and chromosome mapping of pig INSIG 2 and a related pseudogene. Anim Genet. 2005; 36(2):188-9. ing, and phylogenetic analysis. Genomics 2010; 95: 111-119.
16. Li YH, Lei T, Chen XD, Xia T, Peng Y, Long QQ, Zhang J, Feng SQ, Zhou L, Yang ZQ. Molecular cloning, chromosomal location and expression pattern of porcine CIDEa and CIDEc. Molecular Biology Reports 2009; 36:575-82.
17.Peng Y, Lei T, Yuan JH, Chen XD, Long QQ, Zhan J, Lei P, Feng B, Yang ZQ. Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009; 36(3): 491-7.
18. Jin D, Tan HJ, Lei T, Gan L, Chen XD, Long QQ, Feng B, Yang ZQ. Molecular cloning and characterization of porcine sirtuin genes. Comparative Biochemistry and Physiology, Part B 2009; 149: 348-358.
19. Long QQ, Lei T, Feng B, Yin C, Jin D, Wu Y, Zhu X, Chen XD, Gan L, Yang ZQ. Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Endocrinology. 2010; 151(7): 3195-203.
20. Cheng MZ, Yang H, Long H, Chen XD, Yang ZQ, Lei T. Molecular characterization and transcriptional analysis of fad24 in pigs. Gene 2012; 503(2): 208-14.
21. Huang JF, Zhang J, Lei T, Chen XD, Zhang Y, Zhou L, Yu A, Chen ZL, Zhou R, Yang ZQ. Cloning of porcine chemerin, ChemR23 and GPR1 and their involvement in regulation of lipogenesis. BMB reports 2010; 43(7): 491-498.
22. Zhou L, Xia T, Li Y, Chen XD, Peng Y, Yang ZQ. Transcriptional regulation of the resistin gene. Domest Anim Endocrinol. 2006; 30: 98-107.
23. Yin CJ, Long QQ, Lei T, Chen XD, Long H, Peng B, Peng Y, Yang ZQ. Lipid accumulation mediated by adiponectin in C2C12 myogenesis. BMB Rep. 2009; 42:667-72.
24. Dai MH, Xia T, Zhang G, Chen XD, Gan L, Feng SQ, Qiu H, Peng Y, Yang ZQ. Cloning, expression and chromosome localization of porcine adiponectin and adiponectin receptors genes. Domest Anim Endocrinol. 2006; 30: 117-25.
25. Zhang R, Lei T, Qi YM, Lei P, Chen ZL, Chen XD, Yang ZQ. Molecular cloning, chromosomal localization and expression pattern of porcine ADP-ribosylation factor(Arf) gene family. Animal science journal 2010; 81(4): 425-431.
26. Nie T, Zhao XL, Qiu H, Xia T, Chen XD, Gan L, Feng SQ, Lei T, Dai MH, Yang ZQ. Sequencing analysis and map assignment of pig SREBF2 and ADFP gene. Anim Genet. 2005; 36:455-457.
27. Lei T, Yang ZQ, Xia T, Gan L, Chen XD, Yuan JH and Zhu Y. Stage-specific Expression of Leukaemia Inhibitory Factor and its Receptor in Rabbit Pre-implantation Embryo and Uterine Epithelium During Early Pregnancy. Reproduction in Domestic Animals 2004; 39: 13–18.
28. Li XF, Lei T, Xia T, Chen XD, Feng SQ, Chen HP, Chen ZL, Peng Y, Yang ZQ. Molecular characterization, chromosomal and expression patterns of three aquaglyceroporins (AQP3, 7, 9) from pig. Comparative biochemistry and physiology B-Biochemistry &Molecular Biology 2008; 149: 468-476.
29. Qi Y.M, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Molecular biology reports 2009; 36: 1881-1888.
30. Chen HP, Yao W, Jin D, Xia T, Chen XD, Lei T, Zhou L, Yang ZQ. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochemical Genetics 2008; 46: 398-405.
31. Qi YM, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, characterization, chromosomal mapping and tissue transcription analysis of porcine CREB2 and CREB3 genes. Folia Biol (Praha) 2009; 55: 137-144.
32. Xia T, Yuan JH, Gan Li, Feng B, Zhu Y, Chen XD, Zhang Peichao, Yang ZQ. Cloning, chromosome mapping and expression pattern of porcine PLIN and M6PRBP1 genes. Genetics Selection Evolution. 2008; 40(2):215-226.
33. Yue GP, Du LR, Xia T, He XH, Qiu H, Xu LH, Chen XD, Feng SQ, Yang ZQ. One in vitro model for visceral adipose-derived fibroblasts in chronic inflammation. Biochem Biophys Res Commun. 2005; 333:850-857.
34. Chen ZL, Gao X, Lei T, Chen XD, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z.*.Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011;33(7):1327-37.
35. Yu XL, Jin D, Yu A, Sun J, Chen XD, Yang ZQ. p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes. Gene 2016; 589: 12–19.

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