领域：现代农业 学校：合肥工业大学职称：教授
分子营养和食品安全的基础和应用研究1、 食品营养成分神经保护作用及机理；2、食品营养成分安全性评价及毒理学研究，营养素和营养素物质的安全剂量，过量时的毒理作用以及分子机制；3、食物中有毒有害物质对神经系统的损伤作用及其代谢途径和致病机理，食品安全风险评估、预防控制目前承担的科研项目1、国家重点研发计划专项“食品加工条件对食品中外源安全危害物的影响与作用机理”（No. 2018YFC1602201），2018-2021 子课题负责人2、国家“973”计划课题 铅暴露影响脑发育的细胞分子机制（No.2012CB525003） 主持，课题负责人3、国家自然科学基金面上项目（No. 21477031、81773475）、 青年基金（No.31200851） 主持人4、教育部新世纪优秀人才支持计划（NCET-12-0835）主持人5、教育部博士点基金博导类课题 （No. 20130111110024） 主持人代表性研究成果（一） 代表性论文1、Jin-Jun Ding, Rong-Xin Zou, Hui-Ming He, Yu-Qing Tang, Hui-Li Wang*（CA，corresponding author, 通讯作者）. Effect of Pb exposure on synaptic scaling through regulation of AMPA receptor surface trafficking. Toxicological Sciences: an official journal of Society of Toxicology,, 2018 Sep 1;165(1):224-232、Yulan Wu, Yi Xu, Xiyao Huang, Danlei Ye, Miaomiao Han, Hui-Li Wang*. Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity. Toxicological Sciences: an official journal of Society of Toxicology,, 2018 Apr 1;162(2):688-7013、Xiao G*, Liu ZH, Zhao M, Wang HL*, Zhou B*. Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Cell Rep. 2019 Jan 15;26(3):748-758.e5. doi: 10.1016/j.celrep.2018.12.053. (影响因子: 8.032)4、Han Tao, Ji-Sheng Huang, Qiu-Tao Xie, Yong-Ming Zou, Hui-Li Wang*, Xue-Ying Wu, Xue-Ming Xu*. Effect of multiple freezing-thawing cycles on structural and functional properties of starch granules isolated from soft and hard wheat . Food Chemistry, 2018, 265: 18-22. (TOP期刊，一区，热点论文，ESI前0.1%高被引论文)5、Gu X, Han M, Du Y, Wu Y, Xu Y, Zhou X, Ye D, Wang HL*. Pb disrupts autophagic flux through inhibiting the formation and activity of lysosomes in neural cells. Toxicol In Vitro. 2019 Mar;55:43-50. doi: 10.1016/j.tiv.2018.11.010. Epub 2018 Nov 26.6、Ding JJ, Zou RX, He HM, Lou ZY, Xu Y, Wang HL*. Pb inhibits hippocampal synaptic transmission via cyclin-dependent kinase-5 dependent Synapsin 1 phosphorylation. Toxicol Lett. 2018,Oct 15;296:125-131. doi: 10.1016/j.toxlet.2018.08.009. Epub 2018 Aug 16. PMID: 301213407、Yi Xu, Xiang-Tao Chen, Man Luo, Yuqing Tang, Guangxiang Zhang, De Wu, Bin Yang, Di-Yun Ruan, Hui-Li Wang*. ( 2015) Multiple epigenetic factors predict the Attention Deficit/Hyperactivity Disorder among the Chinese Han children. Journal of Psychiatric Research, 2015, 64: 40-50. (影响因子: 4.46)8、Hui-Li Wang, Xiang-Tao Chen, Bin Yang, Fang-Li Ma, Shu Wang, Ming-Liang Tang, Ming-Gao Hao, Di-Yun Ruan, Case-Control Study of Blood Lead Levels and Attention-Deficit Hyperactivity Disorder in Chinese Children, Environmental Health Perspectives, 2008, 116 (10):1401-1406 (环境卫生类Top1杂志，影响因子: 9.776)9、Hui-Li Wang, Zhenjie Zhang, Maik Hintze, Lu Chen. Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity. The Journal of Neuroscience: the official journal of the Society for Neuroscience,,2011, 31(49): 17764-17771 (影响因子: 5.97)10、Hastie, P., Ulrich, M., Wang, H., Arant, R.J., Lau, A.G., Zhang, Z., Isacoff, E.Y. and Chen, L. (2013). AMPA Receptor/TARP stoichiometry visualized by single molecule subunit counting. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(13):5163-5168 (影响因子: 9.846)（二）...
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